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Clinical features of paediatric acute-onset neuropsychiatric syndrome: findings from a case– control study

  • Eva Hesselmark (a1) and Susanne Bejerot (a2)

Abstract

Background

Paediatric acute-onset neuropsychiatric syndrome (PANS), an umbrella term that includes PANDAS (paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) is suggested to be a psychiatric disorder of autoimmune aetiology. PANS is characterised by an acute onset of obsessive–compulsive disorder or restricted eating with multiple comorbid symptoms. The specificity of the PANS criteria is not fully understood.

Aims

To describe a cohort of patients with PANS and to determine if PANS features relating to symptoms, onset and course are more common in PANS than in other psychiatric conditions.

Method

A case–control study comparing patients with interview-confirmed PANS with patients with suspected PANS and patients with a psychiatric condition but with no suspicion of PANS. Validated and non-validated measures of symptoms, onset and episodic course were used.

Results

Illness in patients with interview-confirmed PANS featured an episodic course and multiple symptoms present at onset compared with the psychiatric controls. However, individuals with interview-confirmed PANS did not present a specific symptom profile.

Conclusions

PANS may be a distinct clinical entity featuring an acute onset, an episodic course and multiple symptoms at onset.

Declaration of interest

None.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.

Corresponding author

Correspondence: Eva Hesselmark, CAP Research Center, Karolinska Institutet, Gävlegatan 22, 8tr, 113 30 Stockholm, Sweden. Email: eva.hesselmark@ki.se

References

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Clinical features of paediatric acute-onset neuropsychiatric syndrome: findings from a case– control study

  • Eva Hesselmark (a1) and Susanne Bejerot (a2)
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