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Case series suggesting an association between sertraline and urinary side effects in a Sheffield child and adolescent mental health services (CAMHS) population

Published online by Cambridge University Press:  18 June 2021

Sidra Chaudhry  and
Nisha Alex
Sidra Chaudhry*
Affiliation:
Sheffield Health and Social Care NHS Foundation Trust
Nisha Alex
Affiliation:
Sheffield CAMHS
*
*corresponding author.
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Abstract

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Aims

To suggest a link between sertraline and urinary side effects in a Sheffield Child and Adolescent Mental Health Service population.

Background

Evidence suggests that Serotonin has an important role in bladder control through central and peripheral neurological pathways. Increased serotonergic activity leads to parasympathetic inhibition, which results in urine retention. It is through this mechanism of action and their effect on pre-synaptic serotonin 1A and peripheral 5-HT3 receptors that SSRIs were observed to have anti-enuretic effect. At low 5-HT concentrations, micturition is inhibited whereas at high levels, an excitatory effect is achieved. This may suggest a dose-dependent relationship between Sertraline and urinary side effects.

Method

Inclusion criteria:

Under 18 years of age

On Sertraline

Reported urinary side effects

Exclusion criteria:

Above 18 years

Not on Sertraline

Associated urinary problems

Did not report urinary side effects

Clinical records of eligible patients were accessed to gauge temporal relationship between initiation of sertraline and reported urinary side effects.

Result

Three cases were identified in the authors’ clinical practice at Sheffield CAMHS that were suggestive of a link between sertraline and urinary side effects.

Conclusion

It's important for clinicians to bear in mind the genitourinary side effects of SSRIs, which may be debilitating for patients in the CAMHS population. It's equally important for us as clinicians to educate young people and their parents about these potential side effects and how they can be managed. It has also been observed that higher doses of Sertraline have shown a possible link between onset of urinary side effects.

Type
Research
Information
BJPsych Open , Volume 7 , Supplement S1: Abstracts of the RCPsych Virtual International Congress 2021, 21–24 June , June 2021 , pp. S242
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists
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