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Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

  • Rebecca Henry (a1), Ruth Massey (a2), Kathy Morgan (a3), Johanne Deeks (a4), Hannah Macfarlane (a4) (a5), Nikki Holmes (a6) and Edward Silva (a2)...

Abstract

Aims and method

A series of eleven patients prescribed intramuscular clozapine at five UK sites is presented. Using routinely collected clinical data, we describe the use, efficacy and safety of this treatment modality.

Results

We administered 188 doses of intramuscular clozapine to eight patients. The remaining three patients accepted oral medication. With the exception of minor injection site pain and nodules, side-effects were as expected with oral clozapine, and there were no serious untoward events. Nine patients were successfully established on oral clozapine with significant improvement in their clinical presentations.

Clinical implications

Although a novel formulation in the UK, we have shown that intramuscular clozapine can be used safely and effectively when the oral route is initially refused.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Correspondence to Rebecca Henry (rebecca.henry@southernhealth.nhs.uk)

Footnotes

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Declaration of interest: None.

Footnotes

References

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Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

  • Rebecca Henry (a1), Ruth Massey (a2), Kathy Morgan (a3), Johanne Deeks (a4), Hannah Macfarlane (a4) (a5), Nikki Holmes (a6) and Edward Silva (a2)...

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Evaluation of the effectiveness and acceptability of intramuscular clozapine injection: illustrative case series

  • Rebecca Henry (a1), Ruth Massey (a2), Kathy Morgan (a3), Johanne Deeks (a4), Hannah Macfarlane (a4) (a5), Nikki Holmes (a6) and Edward Silva (a2)...
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