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Can we prevent seasonal affective disorder (SAD) with melatonergic agents?

  • Tarek Zghoul (a1)


Seasonal affective disorder (SAD) is a recurrent form of major depression, particularly occurring in the winter months with a generally spontaneous remission in spring/summer. The predictable nature of this condition provides a potentially unique opportunity to prevent recurrence in sufferers of SAD. The Cochrane Review discussed here examines the evidence for melatonin and agomelatine in preventing SAD, putting its findings into their clinical context.


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Correspondence Tarek Zghoul. Email:


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Commentary on… Melatonin and agomelatine for preventing seasonal affective disorder: a Cochrane Review. See this issue.



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Can we prevent seasonal affective disorder (SAD) with melatonergic agents?

  • Tarek Zghoul (a1)


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