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Bidirectional synaptic plasticity can explain bidirectional retrograde effects of emotion on memory

Published online by Cambridge University Press:  05 January 2017

Bryan A. Strange  and
Ana Galarza-Vallejo
Bryan A. Strange
Affiliation:
Laboratory for Clinical Neuroscience, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spainbryan.strange@upm.esana.galarza@ctb.upm.eswww.thestrangelab.org Department of Neuroimaging, Reina Sofia Centre for Alzheimer's Research, Madrid 28031, Spain
Ana Galarza-Vallejo
Affiliation:
Laboratory for Clinical Neuroscience, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Pozuelo de Alarcón, Madrid 28223, Spainbryan.strange@upm.esana.galarza@ctb.upm.eswww.thestrangelab.org
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Abstract

Emotional events can either impair or enhance memory for immediately preceding items. The GANE model explains this bidirectional effect as a glutamate “priority” signal that modulates noradrenaline release depending on arousal state. We argue for an alternative explanation: that priority itself evokes phasic noradrenaline release. Thus, contrasting E-1 memory effects are explained by a mechanism based on the Bienenstock–Cooper–Munro theory.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e224
Copyright
Copyright © Cambridge University Press 2016 

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