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Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Published online by Cambridge University Press:  05 January 2017


Chadi G. Abdallah
Affiliation:
Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511 chadi.abdallah@yale.edu lynnette.averill@yale.edu john.krystal@yale.edu steven.southwick@yale.edu
Lynnette A. Averill
Affiliation:
Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511 chadi.abdallah@yale.edu lynnette.averill@yale.edu john.krystal@yale.edu steven.southwick@yale.edu
John H. Krystal
Affiliation:
Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511 chadi.abdallah@yale.edu lynnette.averill@yale.edu john.krystal@yale.edu steven.southwick@yale.edu
Steven M. Southwick
Affiliation:
Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511 chadi.abdallah@yale.edu lynnette.averill@yale.edu john.krystal@yale.edu steven.southwick@yale.edu
Amy F. T. Arnsten
Affiliation:
Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 amy.arnsten@yale.edu

Abstract

Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.


Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2016 

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