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Vitamin B6 and immunity

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Vitamin B6 levels are lower in inflammatory conditions and levels are linked with immune response, for example in the critically ill, in autoimmune disorders (such as rheumatoid arthritis) and possibly in HIV infection.

As yet there have been too few clinical trials to tell whether there are specific indications to give B6 supplements in these conditions.

Type
Brief Report
Copyright
Copyright © Cambridge University Press 2007

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References

1. Bolander, FF. Vitamins: not just for enzymes. Curr Opin Investig Drugs. 2006 Oct;7(10):912–5.Google Scholar
2. Grimble, RF. Modification of inflammatory aspects of immune function by nutrients. Nutrition Research 1998 Jul;18(7): 12971317.Google Scholar
3. Trakatellis, A. et al. Pyridoxine deficiency: new approaches in immunosuppression and chemotherapy. Postgrad Med J. 1997 Oct;73(864):617–22.Google Scholar
4. Rall, LC. et al. Vitamin B6 and immune competence. Nutr Rev. 1993 Aug;51(8):217–25.Google Scholar
5. Kwak, HK. et al. Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet. J Nutr. 2002 Nov;132(11):3308–13.Google Scholar
6. Chiang, EP. et al. Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7(6):R1254–62.Google Scholar
7. Friso, S. et al. Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation. 2001 Jun 12;103(23):2788–91.Google Scholar
8. Talwar, D. et al. Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response. Clin Chem. 2003 Mar;49(3):515–8.Google Scholar
9. Pfitzenmeyer, P. et al. Vitamin B6 and vitamin C status in elderly patients with infections during hospitalization. Ann Nutr Metab. 1997;41(6):344–52.Google Scholar
10. Lim, U. et al. Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin's lymphoma: NCI-SEER case-control study, 1998–2000. Am J Epidemiol. 2005 Nov 15;162(10):953–64.Google Scholar
11. Larsson, SC. et al. Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women. Gastroenterology. 2005 Jun;128(7):1830–7.Google Scholar
12. Zhang, SM. et al. Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst. 2003 Mar 5;95(5):373–80.CrossRefGoogle ScholarPubMed
13. Reynolds, RD. Vitamin B6 deficiency and carcinogenesis. Adv Exp Med Biol. 1986;206:339–47.Google Scholar
14. Chiang, EP. et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med. 2003 Mar;114(4):283–7.Google Scholar
15. Schumacher, HR. et al. Vitamin B6 levels in rheumatoid arthritis: effect of treatment. Am J Clin Nutr. 1975 Nov;28(11):1200–3.Google Scholar
16. Namazi, MR. Pyridoxal 5'-phosphate as a novel weapon against autoimmunity and transplant rejection. FASEB J. 2003 Dec;17(15):2184–6.CrossRefGoogle ScholarPubMed
17. Salhany, JM. et al. Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy. J Biol Chem. 1993 Apr 15;268(11):7643–5.CrossRefGoogle ScholarPubMed
18. Dreyfuss, ML. et al. Micronutrients and vertical transmission of HIV-1. Am J Clin Nutr. 2002 Jun;75(6):959–70.CrossRefGoogle ScholarPubMed
19. Baum, MK. et al. Association of vitamin B6 status with parameters of immune function in early HIV-1 infection. J Acquir Immune Defic Syndr. 1991;4(11):1122–32.Google Scholar
20. Cho, YO. et al. Vitamin B6 intake by Koreans should be based on sufficient amount and a variety of food sources. Nutrition. 2005 Nov-Dec;21(11–12):1113–9.Google Scholar
21. Al-Tahan, J. et al. B-vitamin status and intake in European adolescents. A review of the literature. Nutr Hosp. 2006 Jul-Aug;21(4):452–65.Google Scholar
22. Waldmann, A. et al. Dietary intake of vitamin B6 and concentration of vitamin B6 in blood samples of German vegans. Public Health Nutr. 2006 Sep;9(6):779–84.Google Scholar
23. Hansen, CM. et al. Assessment of vitamin B-6 status in young women consuming a controlled diet containing four levels of vitamin B-6 provides an estimated average requirement and recommended dietary allowance. J Nutr. 2001 Jun;131(6):1777–86. Erratum in: J Nutr 2001 Aug;131(8):2224.CrossRefGoogle ScholarPubMed
24. Ebadi, M. et al. Drug-pyridoxal phosphate interactions. Q Rev Drug Metab Drug Interact. 1982;4(4):289331. Review.CrossRefGoogle ScholarPubMed