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Folate and depression

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

There is ample evidence of the link between major depression and low folate levels. This has some genetic element, associated with a polymorphic variant affecting the homocysteine methylation cycle.

A few RCTs have found folate supplements helpful when added to conventional anti-depressants. Depressed patients should be tested for folate and supplemented when folate is low.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 237 , January 2006 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 2006

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