Skip to main content Accessibility help

Broccoli and grapefruit - part 2

In a nutshell

Grapefruit can prolong the half life of various drugs, such as statins and benzodiapenes.

There is also reason to believe that grapefruit - either as juice or the whole fruit - has potential to lower cancer risk, improve insulin response and cardiovascular risk factors, and possibly even help lose weight.



Hide All
1. AD, Helman. Broccoli and grapefruit - part 1. Arbor Clin Nutr Upd 2006;256: 13.
2. Anon. USDA National Nutrient Database for Standard Reference.
3. Foster-Powell, K. et al. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002 Jul;76(1):556.
4. Xu, CJ. et al. Differences in the Carotenoid Content of Ordinary Citrus and Lycopene-Accumulating Mutants. J Agric Food Chem. 2006 Jul 26;54(15):54745481.
5. Ho, PC. et al. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv. 2000 Apr;74(4):379–85.
6. Lichtenthaler, R. et al. Total oxidant scavenging capacities of common European fruit and vegetable juices. J Agric Food Chem. 2005 Jan 12;53(1):103–10.
7. Roy, A. et al. Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom. Biol Pharm Bull. 2006 Feb;29(2):191201.
8. Anon. Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336–9.
9. Vanamala, J. et al. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis. 2006 Jun;27(6):1257–65.
10. Poulose, SM. et al. Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity. J Nutr. 2005 Apr;135(4):870–7.
11. Silalahi, J. Anticancer and health protective properties of citrus fruit components. Asia Pac J Clin Nutr. 2002;11(1):7984.
12. Tian, Q. et al. Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr Cancer. 2001;40(2):180–4.
13. Potter, JD. et al. Vegetables, fruit and phytoestrogens as preventive agents. IARC Sci Publ. 1996;(139):6190.
14. Liu, Y. et al. Citrus pectin: characterization and inhibitory effect on fibroblast growth factor-receptor interaction. J Agric Food Chem. 2001 Jun;49(6):3051–7.
15. Sun, J. et al. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem. 2002 Dec 4;50(25):7449–54.
16. Le, Marchand. et al. Inhibitory effect of grapefruit juice on CYP1A2 activity. 228th American Chemical Society National Meeting. Aug. 21-26 2004. Philadelphia.
17. Le Marchand, L. et al. Intake of flavonoids and lung cancer. J Natl Cancer Inst. 2000 Jan 19;92(2):154–60.
18. Anon. GreatFruit. The FAT BURNER Grapefruit Diet: For Weight-Loss and Cholesterol Reduction.
19. Brown, L. et al. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999 Jan;69(1):3042.
20. De Castro, WV. et al. Abstract Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. J Agric Food Chem. 2006 Jan 11;54(1):249–55.
21. Fujita, K. Food-drug interactions via human cytochrome P450 3A (CYP3A). Drug Metabol Drug Interact. 2004;20(4):195217.
22. Dahan, A. et al. Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance. Eur J Clin Nutr. 2004 Jan;58(1):19.
23. Staudte, H. et al. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J. 2005 Aug 27;199(4):213–7, discussion 210.
24. Colussi, G. et al. Medical prevention and treatment of urinary stones. J Nephrol. 2000 Nov-Dec;13 Suppl 3:S6570.
25. Curhan, GC. et al. Prospective study of beverage use and the risk of kidney stones. Am J Epidemiol. 1996 Feb 1;143(3):240–7.
26. Honow, R. et al. Influence of grapefruit-, orange- and apple-juice consumption on urinary variables and risk of crystallization. Br J Nutr. 2003 Aug;90(2):295300.
27. Goldfarb, DS. et al. Effect of grapefruit juice on urinary lithogenicity. J Urol. 2001 Jul;166(1):263–7.
28. Heggers, JP. et al. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J Altern Complement Med. 2002 Jun;8(3):333–40.
29. Zayachkivska, OS. et al. Influence of plant-originated gastroproteciive and antiulcer substances on gastric mucosal repair. Fiziol Zh. 2004;50(6):118–27.
30. Dembinski, A. et al. Extract of grapefruit-seed reduces acute pancreatitis induced by ischemia/reperfusion in rats: possible implication of tissue antioxidants. J Physiol Pharmacol. 2004 Dec;55(4):811–21.

Related content

Powered by UNSILO

Broccoli and grapefruit - part 2


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.