Skip to main content Accessibility help
×
Home

Berries of many colours

In a nutshell

Berries are one of the richest food sources of antioxidants.

There is quite a bit of animal and in vitro data supporting clinical applications for berries in chronic disease states such as cancer, dementia and cardiovascular disease, and as an anti-microbial. A few human clinical trials are just now starting to appear.

Copyright

References

Hide All
1. Stoner, GD. et al. Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis. 2008 Sep;29(9):1665–74.
2. Zafra-Stone, S. et al. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res. 2007 Jun;51(6):675–83.
3. Neto, CC. Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res. 2007 Jun;51(6):652–64.
4. Bere, E. Wild berries: a good source of omega-3. Eur J Clin Nutr. 2007 Mar;61(3):431–3.
5. Seeram, NP. Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem. 2008 Feb 13;56(3):630–5.
6. Li, J. et al. Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog. 2008 Apr;47(4):286–94.
7. Boivin, D. et al. Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFkappaB by edible berry juice. Anticancer Res. 2007 Mar-Apr;27(2):937–48.
8. Seeram, NP. et al. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006 Dec 13;54(25):9329–39.
9. Chung, MJ. et al. Inhibitory effect of whole strawberries, garlic juice or kale juice on endogenous formation of N-nitrosodimethylamine in humans. Cancer Lett. 2002 Aug 8;182(1):110.
10. Duthie, SJ. Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process. Mol Nutr Food Res. 2007 Jun;51(6):665–74.
11. Bobe, G. et al. Flavonoid consumption and esophageal cancer among black and white men in the United States. Int J Cancer. 2009 Sep 1;125(5):1147–54.
12. Tang, NP. et al. Flavonoids intake and risk of lung cancer: a meta-analysis. Jpn J Clin Oncol. 2009 Jun;39(6):352–9.
13. García-Closas, R. et al. Food, nutrient and heterocyclic amine intake and the risk of bladder cancer. Eur J Cancer. 2007 Jul;43(11):1731–40.
14. Shumway, BS. et al. Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin Cancer Res. 2008 Apr 15;14(8):2421–30.
15. Kresty, LA. et al. Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer. 2006;54(1):148–56.
16. Sakagami, H. et al. Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions. In Vivo. 2007 May-Jun;21(3):499505.
17. Anthony, JP. et al. The effect of blueberry extracts on Giardia duodenalis viability and spontaneous excystation of Cryptosporidium parvum oocysts, in vitro. Methods. 2007 Aug;42(4):339–48.
18. Chatterjee, A. et al. Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin. Mol Cell Biochem. 2004 Oct;265(1–2):1926.
19. Helman, AD. Cranberries. Arb Clin Nutr Upd. 2009 July;310:14.
20. Ofek, I. et al. Anti-Escherichia coli adhesin activity of cranberry and blueberry juices. Adv Exp Med Biol. 1996;408:179–83.
21. Arroyo, FT. et al. Antifungal activity of strawberry fruit volatile compounds against Colletotrichum acutatum. J Agric Food Chem. 2007 Jul 11;55(14):5701–7.
22. Heinonen, M. Antioxidant activity and antimicrobial effect of berry phenolics--a Finnish perspective. Mol Nutr Food Res. 2007 Jun;51(6):684–91.
23. Shukitt-Hale, B. et al. Berry fruit supplementation and the aging brain. J Agric Food Chem. 2008 Feb 13;56(3):636–41.
24. Dai, Q. et al. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med. 2006 Sep;119(9):751–9.
25. Polidori, MC. et al. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimers Dis. 2009 August;17(4):921–27.
26. Balk, E. et al. B vitamins and berries and age-related neurodegenerative disorders. Evid Rep Technol Assess (Full Rep). 2006 Apr;(134):1161.
27. Strömberg, I. et al. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Exp Neurol. 2005 Dec;196(2):298307.
28. Sweeney, MI. et al. Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci. 2002 Dec;5(6):427–31.
29. Papandreou, MA. et al. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res. 2009 Mar 17;198(2):352–8.
30. Galli, RL. et al. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging. 2006 Feb;27(2):344–50.
31. Casadesus, G. et al. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci. 2004 Oct-Dec;7(5–6):309–16.
32. Goyarzu, P. et al. Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci. 2004 Apr;7(2):7583.
33. Joseph, JA. et al. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell. J Alzheimers Dis. 2008 Nov;15(3):429–41.
34. Joseph, JA. et al. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci. 2003 Jun;6(3):153–62.
35. Joseph, JA. et al. Grape juice, berries, and walnuts affect brain aging and behavior. J Nutr. 2009 Sep;139(9):1813S–7S.
36. McGuire, SO. et al. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutr Neurosci. 2006 Oct-Dec;9(5–6):251–8.
37. Krikorian, R. et al. Blueberry Supplementation Improves Memory in Older Adults. Private communication.
38. Krikorian, R. et al. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr in press.
39. Naemura, A. et al. An experimentally antithrombotic strawberry variety is also effective in humans. Pathophysiol Haemost Thromb. 2006;35(5):398404.
40. Naemura, A. et al. Anti-thrombotic effect of strawberries. Blood Coagul Fibrinolysis. 2005 Oct;16(7):501–9.
41. Mudnic, I. et al. Cardiovascular effects in vitro of aqueous extract of wild strawberry (Fragaria vesca, L.) leaves. Phytomedicine. 2009 May;16(5):462–9.
42. Russell, WR. et al. Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications. Mol Nutr Food Res. 2007 Jun;51(6):726–31.
43. Osman, N. et al. Probiotics and blueberry attenuate the severity of dextran sulfate sodium (DSS)-induced colitis. Dig Dis Sci. 2008 Sep;53(9):2464–73.
44. Puupponen-Pimiä, R. et al. Berry phenolics selectively inhibit the growth of intestinal pathogens. J Appl Microbiol. 2005;98(4):9911000.
45. Devareddy, L. et al. Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutr Biochem. 2008 Oct;19(10):694–9.
46. Draelos, ZD. et al. An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin. J Cosmet Dermatol. 2009 Jun;8(2):147–51.
47. Butot, S. et al. Procedure for rapid concentration and detection of enteric viruses from berries and vegetables. Appl Environ Microbiol. 2007 Jan;73(1):186–92.
48. Tournas, VH. et al. Mould and yeast flora in fresh berries, grapes and citrus fruits. Int J Food Microbiol. 2005 Nov 15;105(1):11–7.
49. Robertson, LJ. et al. Occurrence of parasites on fruits and vegetables in Norway. J Food Prot. 2001 Nov;64(11):1793–8.
50. Butot, S. et al. Effects of sanitation, freezing and frozen storage on enteric viruses in berries and herbs. Int J Food Microbiol. 2008 Aug 15;126(1–2):30–5.
51. Hutin, YJ. et al. A multistate, foodborne outbreak of hepatitis A. National Hepatitis A Investigation Team. N Engl J Med. 1999 Feb 25;340(8):595602.
52. Stensvand, A. et al. Investigation on fungicide residues in greenhouse-grown strawberries. J Agric Food Chem. 2000 Mar;48(3):917–20.
53. Hu, R. et al. Solid phase microextraction of pesticide residues from strawberries. Food Addit Contam. 1999 Mar;16(3):111–7.
54. Meeker, JD. et al. Temporal variability of urinary levels of nonpersistent insecticides in adult men. J Expo Anal Environ Epidemiol. 2005 May;15(3):271–81.
55. Zuidmeer, L. et al. The role of profilin and lipid transfer protein in strawberry allergy in the Mediterranean area. Clin Exp Allergy. 2006 May;36(5):666–75.

Related content

Powered by UNSILO

Berries of many colours

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.