Skip to main content Accessibility help
×
Home

Alcohol and heart disease

In a nutshell

The protective association of moderate alcohol consumption on CVD is clear. However, the extent to which this is causal, rather than associated with lifestyle confounders, is not clear.

The polyphenol content of red wine may be specially relevant, but this is also not yet proven. Drinking moderately as accompaniment to healthy and social meals may prove to be the most relevant factor in CV health.

Copyright

References

Hide All
1. Di Castelnuovo, A. et al. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation. 2002 Jun 18;105(24):2836–44.
2. Hines, LM. et al. Moderate alcohol consumption and coronary heart disease: a review. Postgrad Med J. 2001 Dec;77(914):747–52.
3. Gall, N. Is wine good for your heart? A critical review. Postgrad Med J. 2001 Mar;77(905):172–6.
4. Broustet, JP. Wine and health. Heart. 1999 May;81(5):459–60.
5. Marmot, MG. Alcohol and coronary heart disease. Int J Epidemiol. 2001 Aug;30(4):724–9.
6. Rimm, EB. et al. Alcohol in the Mediterranean diet. Am J Clin Nutr. 1995 Jun;61(6 Suppl):1378S1382S.
7. Szmitko, PE. et al. Antiatherogenic potential of red wine: clinician update. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2023–30.
8. Reynolds, K. et al. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003 Feb 5;289(5):579–88.
9. Mazzaglia, G. et al. Exploring the relationship between alcohol consumption and non-fatal or fatal stroke: a systematic review. Addiction. 2001 Dec;96(12):1743–56.
10. Wannamethee, SG. et al. Patterns of alcohol intake and risk of stroke in middle-aged British men. Stroke. 1996 Jun;27(6):1033–9.
11. Gaziano, JM. et al. Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort. J Am Coll Cardiol. 2000 Jan;35(1):96105.
12. Rehm, J. et al. Alcohol and all-cause mortality: an overview. Novartis Found Symp. 1998;216:223–32.
13. Bryson, CL. et al. The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study. J Am Coll Cardiol. 2006 Jul 18;48(2):305–11.
14. Abramson, JL. et al. Moderate alcohol consumption and risk of heart failure among older persons. JAMA. 2001 Apr 18;285(15):1971–7.
15. Klatsky, AL. Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and hypertension: does it matter? Yes. J Cardiovasc Risk. 2003 Feb;10(1):21–4.
16. Ohmori, S. et al. Alcohol intake and future incidence of hypertension in a general Japanese population: the Hisayama study. Alcohol Clin Exp Res. 2002 Jul;26(7):1010–6.
17. Renaud, SC. et al. Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men. Am J Clin Nutr. 2004 Sep;80(3):621–5.
18. Malinski, MK. et al. Alcohol consumption and cardiovascular disease mortality in hypertensive men. Arch Intern Med. 2004 Mar 22;164(6):623–8.
19. Klatsky, AL. Should patients with heart disease drink alcohol? JAMA. 2001 Apr 18;285(15):2004–6.
20. Tjonneland, A. et al. Wine intake and diet in a random sample of 48763 Danish men and women. Am J Clin Nutr. 1999 Jan;69(1):4954.
21. Christensen, JH. et al. Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation. 2001 Feb 6;103(5):651–7.
22. Mukamal, KJ. et al. Alcohol consumption, physical activity, and chronic disease risk factors: a population-based cross-sectional survey. BMC Public Health. 2006 May 3;6:118.
23. Barrett, DH. et al. The association between alcohol use and health behaviors related to the risk of cardiovascular disease: the South Carolina Cardiovascular Disease Prevention Project. J Stud Alcohol. 1995 Jan;56(1):915.
24. Lussier-Cacan, S. et al. Impact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotype. Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):824–31.
25. Rimm, EB. et al. Wine, beer, and spirits: are they really horses of a different color? Circulation. 2002 Jun 18;105(24):2806–7.
26. Janszky, I. et al. Wine drinking is associated with increased heart rate variability in women with coronary heart disease. Heart. 2005 Mar;91(3):314–8.
27. Mattace-Raso, FU. et al. Moderate alcohol consumption is associated with reduced arterial stiffness in older adults: the Rotterdam study. J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1479–83.
28. Mukamal, KJ. et al. Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study. Alcohol Clin Exp Res. 2005 Oct;29(10):1906–12.
29. Salem, RO. et al. Effects of alcohol on hemostasis. Am J Clin Pathol. 2005 Jun;123 Suppl:S96–105.
30. Volpato, S. et al. Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study. Circulation. 2004 Feb 10;109(5):607–12.
31. Chung, BH. et al. Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease. Am J Clin Nutr. 2003 Sep;78(3):391–9.
32. Puddey, IB. et al. Alcohol, free radicals and antioxidants. Novartis Found Symp. 1998;216:5162.
33. Roberts, R. et al. Psychological factors in the relationship between alcohol and cardiovascular morbidity. Soc Sci Med. 1995 Dec;41(11):1513–6.
34. Murray, RP. et al. Does personality mediate the relation between alcohol consumption and cardiovascular disease morbidity and mortality? Addict Behav. 2005 Mar;30(3):475–88.
35. Djousse, L. et al. Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr. 2004 Dec;80(6):1639–44.
36. Younis, J. et al. Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study. Atherosclerosis. 2005 Jun;180(2):225–32.
37. Mumenthaler, MS. et al. Gender differences in moderate drinking effects. Alcohol Res Health. 1999;23(1):5564.
38. Marmot, MG. Commentary: reflections on alcohol and coronary heart disease. Int J Epidemiol. 2001 Aug;30(4):729–34.
39. Gronbaek, M. Alcohol and cardiovascular disease--more than one paradox to consider. Type of alcoholic beverage and cardiovascular disease--does it matter? J Cardiovasc Risk. 2003 Feb;10(1):510.
40. Fuhrman, B. et al. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr. 1995 Mar;61(3):549–54.
41. de Gaetano, G. et al. Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption. Ann N Y Acad Sci. 2002 May;957:174–88.
42. Nigdikar, SV. et al. Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. Am J Clin Nutr. 1998 Aug;68(2):258–65.
43. Mukamal, KJ. et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med. 2003 Jan 9;348(2):109–18.
44. Bobak, M. et al. Effect of beer drinking on risk of myocardial infarction: population based case-control study. BMJ. 2000 May 20;320(7246):1378–9.
45. Zilkens, RR. et al. Alcohol and cardiovascular disease--more than one paradox to consider. Alcohol and type 2 diabetes--another paradox? J Cardiovasc Risk. 2003 Feb;10(1):2530.
46. Cooper, DE. et al. Is insulin sensitivity a causal intermediate in the relationship between alcohol consumption and carotid atherosclerosis?: the insulin resistance and atherosclerosis study. Diabetes Care. 2002 Aug;25(8):1425–31.
47. Goldberg, IJ. et al. AHA Science Advisory. Wine and your heart: A science advisory for healthcare professionals from the Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Association. Stroke. 2001 Feb;32(2):591–4.
48. Britton, A. et al. The relation between alcohol and cardiovascular disease in Eastern Europe: explaining the paradox. J Epidemiol Community Health. 2000 May;54(5):328–32.

Related content

Powered by UNSILO

Alcohol and heart disease

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.