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Homocysteine & heart disease: 2006

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

The latest RCT evidence does not support giving Hcylowering vitamin supplements to prevent heart disease.

However, a tentative result in preventing stroke, positive outcomes from a few previous but smaller RCTs, and some benefits seen for intermediary outcomes (such as restenosis) in other studies, all suggest that this topic requires more research.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 258 , July 2006 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 2006

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References

1. Refsum, H. et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006 Jun;136(6 Suppl):1731S–1740S.Google Scholar
2. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002 Oct 23-30;288(16):2015–22.Google Scholar
3. Wald, DS. et al. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002 Nov 23;325(7374):1202.Google Scholar
4. Wald, DS. et al. The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening. Eur J Cardiovasc Prev Rehabil. 2004 Jun;11(3):250–3.Google Scholar
5. Loscalzo, J. Homocysteine trials--clear outcomes for complex reasons. N Engl J Med. 2006 Apr 13;354(15):1629–32.CrossRefGoogle ScholarPubMed
6. Haim, M. et al. Serum Homocysteine and Long-Term Risk of Myocardial Infarction and Sudden Death in Patients with Coronary Heart Disease. Cardiology 2006 Jun 6;107(1):52–56.Google Scholar
7. Selhub, J. The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J Nutr. 2006 Jun;136(6 Suppl):1726S–1730S.Google Scholar
8. McNulty, H. et al. Riboflavin lowers homocysteine in individuals homozygous fo the MTHFR 677C->T polymorphism. Circulation. 2006 Jan 3;113(1):74–80.Google Scholar
9. Signorelli, SS. et al. Propionyl-L-Carnitine Therapy: Effects on Endothelin-1 and Homocysteine Levels in Patients with Peripheral Arterial Disease and End-Stage Renal Disease. Kidney Blood Press Res. 2006 Jun 30;29(2):100–107.Google Scholar
10. Chait, A. et al. Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease. Am J Clin Nutr. 1999 Nov;70(5):881–7.Google Scholar
11. Dusitanond, P. et al. Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy of the VITATOPS trial. Stroke. 2005 Jan;36(1):144–6.CrossRefGoogle ScholarPubMed
12. Spence, JD. Homocysteine: call off the funeral. Stroke. 2006 Feb;37(2):282–3.Google Scholar
13. Flicker, L. et al. Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia. Stroke. 2006 Feb;37(2):547–9.Google Scholar
14. Clarke, R. et al. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Semin Thromb Hemost. 2000;26(3):341–8.Google Scholar
15. Mangoni, AA. et al. Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes. Am J Hypertens. 2005 Feb;18(2 Pt 1):220–6.Google Scholar
16. Chia, S. et al. Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation. Clin Sci (Lond). 2005 Jan;108(1):65–72.Google Scholar
17. Williams, C. et al. Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr. 2005 Jul;82(1):26–31.Google Scholar
18. Vermeulen, EG. et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet. 2000 Feb 12;355(9203):517–22.Google Scholar
19. Vermeulen, EG. et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B on cerebrovascular atherosclerosis and white matter abnormalities as determined by MRA and MRI: a placebo-controlled, randomized trial. Eur J Clin Invest. 2004 Apr;34(4):256–61.Google Scholar
20. Klerk, M. et al. No effect of folic acid supplementation in the course of 1 year on haemostasis markers and C-reactive protein in older adults. Thromb Haemost. 2005 Jul;94(1):96–100.Google Scholar
21. Manrique, J. et al. Preliminary results of the effect of treatment of hyperhomocysteinemia and its relationship with inflammation, coagulation status, and endothelial function after renal transplantation. Transplant Proc. 2005 Nov;37(9):3782–4.Google Scholar
22. Marcucci, R. et al. Homocysteine-lowering therapy and carotid intima-media thickness in renal transplant recipients. Transplant Proc. 2005 Jul-Aug;37(6):2491–2.Google Scholar
23. Schnyder, G. et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med. 2001 Nov 29;345(22):1593–600.Google Scholar
24. Lange, H. et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med. 2004 Jun 24;350(26):2673–81.CrossRefGoogle ScholarPubMed
25. Toole, JF. et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004 Feb 4;291(5):565–75.Google Scholar
26. Schnyder, G. et al. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002 Aug 28;288(8):973–9.Google Scholar
27. Righetti, M. et al. Homocysteine-Lowering Vitamin B Treatment Decreases Cardiovascular Events in Hemodialysis Patients. Blood Purif. 2006 Jun 1;24(4):379–386.Google Scholar
28. Spence, JD. et al. Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Stroke. 2005 Nov;36(11):2404–9.Google Scholar
29. MacMahon, M. et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis. 2000 Aug;10(4):195–203.Google Scholar