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Northwest African distribution of the CD4/Alu microsatellite haplotypes

Published online by Cambridge University Press:  26 July 2016

C. FLORES ,
N. MACA-MEYER ,
A. M. GONZÁLEZ  and
V. M. CABRERA
C. FLORES
Affiliation:
Departamento de Genética, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain
N. MACA-MEYER
Affiliation:
Departamento de Genética, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain
A. M. GONZÁLEZ
Affiliation:
Departamento de Genética, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain
V. M. CABRERA
Affiliation:
Departamento de Genética, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain
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Abstract

We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu(−) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(−) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.

Type
Research Article
Information
Annals of Human Genetics , Volume 64 , Issue 4 , July 2000 , pp. 321 - 327
Copyright
University College London 2000

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