Hostname: page-component-84b7d79bbc-g5fl4 Total loading time: 0 Render date: 2024-08-04T18:17:44.373Z Has data issue: false hasContentIssue false

Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs

Published online by Cambridge University Press:  01 January 1998

M. KNAPP
Affiliation:
Institute for Medical Statistics, University of Bonn
Get access

Abstract

Risch and Zhang recently proposed to use extreme discordant sib pairs for mapping quantitative trait loci. Here, it is shown that the set of genetically possible distributions of the number of marker alleles in such sib-pairs is described by two inequalities. Thus, a likelihood ratio test analogous to Holmans's possible triangle test for affected sib pairs can be defined. The performance of this test is compared to the mean test considered by Risch and Zhang. For most of the genetic models considered, the mean test is slightly more powerful than the restricted likelihood ratio test. However, for models with a rare recessive gene (or equivalently a common dominant gene), the restricted likelihood ratio test is much more powerful.

Type
Research Article
Copyright
© University College London 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)