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Reducing the number of animals used in behavioural genetic experiments using chromosome substitution strains

Published online by Cambridge University Press:  11 January 2023

MC Laarakker ,
F Ohl  and
HA van Lith
MC Laarakker*
Affiliation:
Department of Animals, Science & Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
F Ohl
Affiliation:
Department of Animals, Science & Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
HA van Lith
Affiliation:
Department of Animals, Science & Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
*
* Contact for correspondence and requests for reprints: M.C.Laarakker@vet.uu.nl
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Abstract

Chromosome substitution strains (also called consomic lines or strains) are strains in which a single, full-length chromosome from one inbred strain — the donor strain — has been transferred onto the genetic background of a second inbred strain — the host strain. Based on the results obtained from behavioural tests with the two parental strains, the minimum number of animals from each of the host and consomic strains that are required for a successful behavioural genetic analysis can be estimated. Correct application of statistical knowledge can lead to a further reduction in the number of animals used in behavioural genetic experiments using chromosome substitution strains.

Keywords

animal welfarebehavioural geneticschromosome substitution strainmiceQTLreduction
Type
Research Article
Information
Animal Welfare , Volume 15 , Issue 1 , February 2006 , pp. 49 - 54
Copyright
© 2006 Universities Federation for Animal Welfare

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