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Intra-Abdominal Transmitter Implantation in Mice: Effects on Behaviour and Body Weight

Published online by Cambridge University Press:  11 January 2023

V Baumans ,
J A Bouwknecht ,
H Boere ,
K Kramer ,
H A van Lith ,
H A van de Weerd  and
H van Herck
V Baumans
Affiliation:
Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
J A Bouwknecht
Affiliation:
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands
H Boere
Affiliation:
Central Laboratory Animal Institute, Utrecht University, The Netherlands
K Kramer
Affiliation:
LACDR, Department of Pharmacochemistry, Free University, Amsterdam, The Netherlands
H A van Lith
Affiliation:
Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
H A van de Weerd
Affiliation:
Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
H van Herck
Affiliation:
Central Laboratory Animal Institute, Utrecht University, The Netherlands
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Abstract

Biotelemetry is a useful tool for the simultaneous measurement of several physiological and behavioural parameters in non-restrained, freely moving animals. However, the weight and volume of the implanted intra-abdominal transmitter may cause discomfort. The aim of this study was to assess body weight and behaviour of BALB/c and 129/Sv mice after implantation of an intra-abdominal transmitter. In order to measure more detailed behaviour, the automated behaviour observation analysis system (LABORAS™) was used. During the first days after surgery, body weight and the behaviours of climbing, locomotion and eating were found to decrease in both strains, whereas grooming and immobility increased. These changes were more pronounced in the transmitter animals than in the sham operated animals, however, indicating a temporary impairment in well-being. Within two weeks after surgery, the animals seemed to have fully recovered.

Keywords

micetelemetrytransmitter implantation
Type
Research Article
Information
Animal Welfare , Volume 10 , Issue 3 , August 2001 , pp. 291 - 302
Copyright
© 2001 Universities Federation for Animal Welfare

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References

Baumans, V, Schlingmann, F, van Herck, H, Boere, HAG and Tolboom, J 1996 Assessment of discomfort in the mouse by means of a balance device. Proceedings of the Sixth FELASA Symposium: Harmonization of laboratory animal husbandry, 19—21 June, Basel, Switzerland pp 14–16. P N O'Donoghue (ed). Royal Society of Medicine Press Ltd: London, UKGoogle Scholar
Brockway, B P and Hassler, C R 1993 Application of radio telemetry to cardiovascular measurements in pharmacology and toxicology. In: Salem, H and Baskin, SI (eds) New Technologies and Concepts for Reducing Drug Toxicity pp 109–132. CRC Press: Boca Raton, FL, USAGoogle Scholar
Brockway, B P, Mills, P and Kramer, K 1998 Fully implanted radio-telemetry for monitoring laboratory animals. Laboratory Animals 27: 40–46Google Scholar
Bulthuis, R J A, Bergman, A F, Nijessen, S, Schlingmann, F, Tolboom, J, Remie, R, van de Weerd, H A, van Loo, P L P, Baumans, V and Van Zutphen, L F M 1996 Automated behaviour classification: the LABORAS™ project. Proceedings of the Sixth FELASA Symposium: Harmonization of laboratory animal husbandry, 19-21 June, Basel, Switzerland pp 17–18. P N O'Donoghue (ed). Royal Society of Medicine Press Ltd: London, UKGoogle Scholar
Büttner, D 1991 Climbing on the cage lid, a regular component of locomotor activity in the mouse. Journal of Experimental Animal Science 34: 165–169Google Scholar
Hora, S C and Conover, W J 1984 The F statistic in the two-way lay-out with rank-score transformed data. Journal of American Statistical Association 79: 668–673Google Scholar
Kinter, L B 1996 Cardiovascular telemetry and laboratory animal welfare: new reduction and refinement alternatives. General Pharmacology/Safety Pharmacology Meeting, Philadelphia, PA, USAGoogle Scholar
Kramer, K, van Acker, S ABE, Voss, H-P, Grimbergen, J A, van der Vijgh, W J F and Bast, A 1993 Use of telemetry to record electrocardiogram and heart rate in freely moving mice. Journal of Pharmacological and Toxicological Methods 30: 209–215Google ScholarPubMed
Kramer, K, van Acker, S ABE, Grimbergen, J A, van der Vijgh, W J F and Bast, A 1996 Application possibilities of telemetry in small laboratory animals. Proceedings of the Sixth FELASA Symposium: Harmonization of laboratory animal husbandry, 19-21 June, Basel, Switzerland pp 92–94. P N O'Donoghue (ed). Royal Society of Medicine Press Ltd: London, UKGoogle Scholar
Schlingmann, F, van de Weerd, H A, Baumans, V, Remie, R and van Zutphen, L F M 1998 A balance device for the analysis of behavioural patterns of the mouse. Animal Welfare 7: 177–188CrossRefGoogle Scholar
Schnell, C R and Gerber, P 1997 Training and remote monitoring of cardiovascular parameters in nonhuman primates. Primate Report 49: 61 -70Google Scholar
SPSS Inc 1990 SPSS/PC+™ 4.0 Advanced Statistical Manual for the IBM PC XT/AT and PS/2V (release 4.0). SPSS Inc., Chicago, IL, USAGoogle Scholar
Steel, R G D and Torrie, J H 1981 Principles and Procedures of Statistics. A Biomedical Approach (2nd Edition). McGraw-Hill: SingaporeGoogle Scholar
Stokstad, E 1999 Humane science finds sharper and kinder tools. Science 286: 1068–1071CrossRefGoogle ScholarPubMed
Van Acker, S ABE, Kramer, K, Voest, E E, Grimbergen, J A, Zhang, J, van der Vijgh, W J F and Bast, A 1996 Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice: a new model to test potential protectors. Cancer, Chemotherapy and Pharmacology 38: 95–101CrossRefGoogle ScholarPubMed
Van de Weerd, H A, Baumans, V, Koolhaas, J M and van Zutphen, L F M 1994 Strain specific behavioural response to environmental enrichment in the mouse. Journal of Experimental Animal Science 36: 117–127Google ScholarPubMed
Van de Weerd, H A, Bulthuis, R J A, Bergman, A F, Schlingmann, F, Tolboom, J, van Loo, P L P, Remie, R, Baumans, V and van Zutphen, L F M 2001 Validation of a new system for the automatic registration of behaviour in mice and rats. Behavioural Processes 53: 11–20CrossRefGoogle ScholarPubMed