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Is sodium fluoroacetate (1080) a humane poison?

Published online by Cambridge University Press:  11 January 2023

M Sherley*
Affiliation:
RSPCA Australia, PO Box 265, Deakin West, Canberra 2600, Australia

Abstract

Sodium fluoroacetate (1080) is widely used for the control of vertebrate pests in Australia. While the ecological impact of 1080 baiting on non-target species has been the subject of ongoing research, the animal welfare implications of this practice have received little attention. Literature relevant to the humaneness of 1080 as a vertebrate pest control agent is reviewed in this paper. Previous authors have largely concentrated on the perception of pain during 1080 toxicosis, giving limited attention to other forms of distress in their assessments. Authors who suggest that 1080 is a humane poison largely base their conclusions on the argument that convulsive seizures seen in the final stages of 1080 toxicosis indicate that affected animals are in an unconscious state and unable to perceive pain. Other authors describe awareness during seizures or periodic lucidity that suggests central nervous system (CNS) disruption cannot be assumed to produce a constant pain-free state. Some literature report that 1080 poisoning in humans is painless and free of distress, but this is contradicted by other clinical studies. Using available data an attempt is made to reassess the humaneness of 1080 using the following criteria: speed and mode of action, appearance and behaviour of affected animals, experiences of human victims, long-term effect on survivors, and welfare risk to non-target animals. It is concluded that sodium fluoroacetate should not be considered a humane poison, and there is an urgent need for research into improving the humaneness of vertebrate control methods in Australia.

Type
Articles
Copyright
© 2007 Universities Federation for Animal Welfare

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References

Aggarwal, P and Prakash Wali, J 1997 Diagnosis and Management of Common Poisoning. Oxford University Press: Oxford, UKGoogle Scholar
Bell, J 1972 The acute toxicity of four common poisons to the opossum Trichosurus vulpecula. New Zealand Veterinary Journal 20: 21221410.1080/00480169.1972.34053CrossRefGoogle Scholar
Biodiversity Group Environment Australia 1999 Threat abatement plan for competition and land degradation by feral rabbits. Australian Government Department of Environment and Heritage: Commonwealth of AustraliaGoogle Scholar
Book, D 2004 Disorders of brain function. In: Porth, CM (ed) Pathophysiology: Concepts of Altered Health States, 7th edition. Lippincott Williams and Wilkins: Philadelphia, USAGoogle Scholar
Bowen, LH, Morgan, DR and Eason, CT 1995 Persistence of sodium monofluoroacetate (1080) in baits under simulated rainfall. New Zealand Journal of Agricultural Research 38: 529531CrossRefGoogle Scholar
Brockman, JL, McDowell, AV and Leeds, WG 1955 Fatal poisoning with sodium monofluoroacetate. Journal of the American Medical Association 159: 1529153210.1001/jama.1955.02960330029010CrossRefGoogle Scholar
Chenoweth, MB and Gilman, A 1946 Studies on the pharmacology of fluoroacetate I. Species responses to fluoroacetate. Journal of Pharmacology 87: 90103Google ScholarPubMed
Chenoweth, MB and St John, EF 1947a Spike and dome formations produced in the dog's electroencephalogram by fluoroacetic acid. Proceedings of the Association for Research in Nervous and Mental Disorders 26: 299307Google Scholar
Chenoweth, MB and St John, EF 1947b Studies on the pharmacology of fluoroacetate III. Effects on the central nervous system of dogs and rabbits. Journal of Pharmacology and Experimental Therapeutics 90: 7682Google Scholar
Chi, CH, Chen, KW, Chan, SH, Wu, MH and Huang, JJ 1996 Clinical presentation and prognostic factors in sodium monofluoroacetate intoxication. Journal of Toxicology. Clinical Toxicology 34: 70771210.3109/15563659609013833CrossRefGoogle ScholarPubMed
Chung, HM 1984 Acute renal failure caused by acute monofluoroacetate poisoning. Veterinary and Human Toxicology 26(52): 2932Google ScholarPubMed
Dexter, N and Meek, P 1998 An analysis of bait-take and nontarget impacts during a fox control exercise. Wildlife Research 15: 14715510.1071/WR97020CrossRefGoogle Scholar
Dreisbach, RH 1983 Handbook of Poisoning: Prevention, Diagnosis and Treatment, 11th edition. Lange Medical Publications: Los Altos, California, USAGoogle Scholar
DuBose, TD Jr 2005 Acidosis and Alkalosis. In: Kasper, DL, Braunwald, E, Fauci, AS, Hamser, SL, Longo, DL, Jameson, L and Isselbacher, KJ (eds) Harrison's Principles of Internal Medicine, 16th edition. McGraw-Hill: New York, USAGoogle Scholar
Eason, CT and Turck, P 2002 A 90-day toxicological evaluation of compound 1080 (sodium monofluoroacetate) in Sprague-Dawley rats. Toxicological Sciences 69: 43944710.1093/toxsci/69.2.439CrossRefGoogle ScholarPubMed
Egekeze, JO and Oehme, FW 1979a Sodium monofluoroacetate (SMFA, compound 1080): A literature review. Veterinary and Human Toxicology 21:411-416Google Scholar
Egekeze, JO and Oehme, FW 1979b Inorganic and organic fluoride concentrations in tissues after the oral administration of sodium monofluoroacetate (Compound 1080) to rats. Toxicology 15: 435310.1016/0300-483X(79)90018-0CrossRefGoogle ScholarPubMed
Fairbridge, D, Fisher, P, Busana, F, Pontin, K, Edwards, A, Johnston, M and Shaw, M 2000 Observations of the behaviour of free living bush rat, Rattus fuscipes and southern brown bandicoot, Isoodon obesulus at buried bait stations. Australian Mammalogy 15: 12512710.1071/AM00125CrossRefGoogle Scholar
Fairbridge, D, Anderson, R, Wilkes, T and Pell, G 2003 Bait uptake by free living brush-tailed phasgogale, Phasgogale tapoatafa and other non-target mammals during simulated buried fox baiting. Australian Mammalogy 25: 3140CrossRefGoogle Scholar
Fanshier, DW, Gottwald, LK and Kun, E 1964 Studies of specific enzyme inhibitors VI. Characterisation and mechanism of action of the enzyme inhibitory isomer of monofluorocitrate. The Journal of Biological Chemistry 239: 42543410.1016/S0021-9258(18)51696-3CrossRefGoogle ScholarPubMed
Foss, GL 1948 The toxicology and pharmacology of methyl fluoroacetate (MFA) in animals, with some notes on experimental therapy. British Journal of Pharmacology 3: 118127Google Scholar
Gajdusek, DC and Luther, G 1950 Fluoroacetate poisoning: A review and report of a case. American Journal of Diseases of Children 79: 31032010.1001/archpedi.1950.04040010321007CrossRefGoogle ScholarPubMed
Glen, AS and Dickman, CR 2003a Monitoring bait removal in vertebrate pest control: a comparison using track identification and remote photography. Wildlife Research 30: 293310.1071/WR01059CrossRefGoogle Scholar
Glen, AS and Dickman, CR 2003b Effects of bait station design on the uptake of baits by non-target animals during control programmes for foxes and wild dogs. Wildlife Research 30: 147149CrossRefGoogle Scholar
Godoy, HM and del Carmen Villarruel, M 1974 Myocardial adenine nucleotides, hexose phosphates and inorganic phosphate, and the regulation of phosphofructokinase activity during fluoroacetae poisoning in the rat. Biochemical Pharmacology 23: 31793189CrossRefGoogle ScholarPubMed
Government of Western Australia 2002 1080 Summary information. Miscellaneous publication number no 011/2002. Government of Western Australia, Departments of Agriculture, Conservation and Land Management and Health: Western Australia, AustraliaGoogle Scholar
Gregory, G 1996 Perception of pain associated with 1080 poisoning. In: Marks, CA and Fisher, PM (eds) Humaneness of Vertebrate Pest Control pp 6264. Ropet Printing: Tynong North, AustraliaGoogle Scholar
Harris, WF 1975 Clinical toxicities of dogs. The Veterinary Clinics of North America 5: 605622CrossRefGoogle ScholarPubMed
King, DR 1989 An assessment of the hazard posed to northern quolls (Dasyurus hallucatus) by aerial baiting with 1080 to control dingoes. Australian Wildlife Research I 1: 569574CrossRefGoogle Scholar
King, DR, Kirkpatrick, WE, Wong, DH and Kramer, JE 1994 Degradation of 1080 in Australian soils. In: Seawright, AA and Eason, CT (eds) Proceedings of the Science Workshop on 1080 pp 4549. Royal Society of New Zealand Miscellaneous Series 28: Wellington, New ZealandGoogle Scholar
Kirsten, E, Sharma, ML and Kun, E 1978 Molecular toxicity of (−) erythro-fluorocitrate: selective inhibition of citrate transport in mitochondria and the binding of fluorocitrate to mitochondrial proteins. Molecular Pharmacology 14: 172184Google Scholar
Kortner, G, Gresser, S and Harden, B 2003 Does fox baiting threaten the spotted-tailed quoll, Dasyurus maculates! Wildlife Research 30: 111118CrossRefGoogle Scholar
McIlroy, JC 1981 The sensitivity of Australian animals to 1080 poison II. Marsupial and eutherian carnivores. Australian Wildlife Research 8: 38539910.1071/WR9810385CrossRefGoogle Scholar
McIlroy JC 1982a The sensitivity of Australian animals to 1080 poison III. Marsupial and eutherian herbivores. Australian Wildlife Research 9: 487503Google Scholar
McIlroy JC 1982b The sensitivity of Australian animals to 1080 poison IV. Native and introduced rodents. Australian Wildlife Research 9: 505517Google Scholar
McIlroy JC 1982c The sensitivity of Australian carnivorous mammals to 1080 poison. In: Archer, M (ed) Carnivorous Marsupials pp 267271. Surrey Beatty and Sons: Royal Zoological Society of NSW, Mossman, NSW, AustraliaGoogle Scholar
McIlroy, JC 1983 The sensitivity of Australian animals to 1080 poison V. The sensitivity of feral pigs, Sus scrofa, to 1080 and its implications for poisoning campaigns. Australian Wildlife Research 10: 139148CrossRefGoogle Scholar
McIlroy, JC 1984 The sensitivity of Australian animals to 1080 poison VII. Native and introduced birds. Australian Wildlife Research 11: 373385CrossRefGoogle Scholar
McIlroy, JC 1985 The sensitivity of Australian animals to 1080 poison VIII. Amphibians and reptiles. Australian Wildlife Research 12: 113118CrossRefGoogle Scholar
McIlroy, JC 1986 The sensitivity of Australian animals to 1080 poison IX. Comparisons between the major groups of animals, and the potential danger non-target species face from 1080-poisoning campaigns. Australian Wildlife Research 13: 394810.1071/WR9860039CrossRefGoogle Scholar
McIlroy, JC, Cooper, RJ, Gifford, EJ, Green, BF, and Newgrain, KW 1986 The effect on wild dogs, Canis f. familiaris of 1080-poisoning campaigns in Kosciusko National Park NSW. Australian Wildlife Research 13: 53554410.1071/WR9860535CrossRefGoogle Scholar
McIlroy, JC and Gifford, EJ 1991 Effects on non-target animal populations of a rabbit trail-baiting campaign with 1080 poison. Wildlife Research 18: 31532510.1071/WR9910315CrossRefGoogle Scholar
McIlroy, JC, Gifford, EJ and Carpenter, SM 1988 The effect of rainfall and blowfly larvae on the toxicity of ‘1080’ treated baits used in poisoning campaigns against wild dogs. Australian Wildlife Research 15: 47348310.1071/WR9880473CrossRefGoogle Scholar
McIlroy, JC 1996 Rationale for the use of 1080 to control vertebrate pests. In: Fisher, PM and Marks, CA (eds) Humaneness of Vertebrate Pest Control pp 2733. Ropet Printing: Tynong North, AustraliaGoogle Scholar
McTaggart, DR 1970 Poisoning due to sodium fluoroacetate (“ 1080”). Medical Journal of Australia 2: 641 -64210.5694/j.1326-5377.1970.tb50243.xCrossRefGoogle ScholarPubMed
Marks, CA 2001 Bait-delivered cabergoline for the reproductive control of the red fox (Vulpes vulpes): estimating mammalian nontarget risk in south-eastern Australia. Reproduction Fertility and Development 13: 499510CrossRefGoogle ScholarPubMed
Marks, CA, Hackman, C, Busana, F, and Gigliotti, F 2000 Assuring that 1080 toxicosis in the red fox (Vulpes vulpes) is humane: fluoroacetic acid (1080) and drug combinations. Wildlife Research 27: 483494CrossRefGoogle Scholar
Marks, CA, Gigliotti, F, Busana, F, Johnston, M and Lindeman, M 2004 Fox control using a para-aminopropiophenone formulation with the M-44 ejector. Animal Welfare 13: 401407CrossRefGoogle Scholar
Marks, CA and Wilson, RL 2005 Predicting mammalian target-specificity of the M-44 ejector in south-eastern Australia. Wildlife Research 32: 15115610.1071/WR03102CrossRefGoogle Scholar
Mason, G and Littin, KE 2003 The humaneness of rodent pest control. Animal Welfare 12: 13710.1017/S0962728600025355CrossRefGoogle Scholar
Meenken, DR and Booth, L 1997 The risk to dogs of poisoning from sodium monofluoroacetate (1080) residues in possum (Trichosurus vulpecula). New Zealand Journal of Agricultural Research 40: 573576CrossRefGoogle Scholar
Mehlman, MA 1967 Inhibition of pyruvate carboxylation by fluorocitrate in rat kidney mitochondria. The Journal of Biological Chemistry 243: 1919192510.1016/S0021-9258(18)93528-3CrossRefGoogle Scholar
Meldrum, GK, and Bignell, JT 1957 The use of sodium fluoroacetate (compound 1080) for the control of the rabbit in Australia. Australian Veterinary Journal 33: 186196CrossRefGoogle Scholar
Morgan, DR 1990 Behavioural response of brushtail possums, Trichosurus vulpecula, to baits used in pest control. Australian Wildlife Research 17: 601613CrossRefGoogle Scholar
Peters, RS 1952 Lethal Synthesis. Proceedings of the Royal Society of London 139: 142170Google ScholarPubMed
Peters, RA, Spencer, H, and Bidstrup, PL 1981 Subacute fluoroacetate poisoning. Journal of Occupational Medicine 23: 112113CrossRefGoogle ScholarPubMed
Potter, MA, Barrett, DP, and King, CM 2006 Acceptance by stoats (Mustela erminea) of 1080 (sodium monofluoroacetate) in small-volume baits and its effect on behaviour and time to death. New Zealand Veterinary Journal 54: 350356CrossRefGoogle ScholarPubMed
Pridmore, SA 1978 Fluoroacetate poisoning: nine years later. Medical Journal of Australia 2: 269270Google ScholarPubMed
Quin, JI and Clark, R 1947 Studies on the action of potassium monofluoroacetate (CH2 FCOOK) (Dichapetalum cymosum) (Hook, England) toxin on animals. Onderstepoort Journal of Veterinary Science and Animal Industry 22: 241 -246Google Scholar
Ramirez, M 1986 Inebriation with pyridoxine and fluoroacetate: a case report. Veterinary and Human Toxicology 28: 154Google ScholarPubMed
Reigart, JR, Brueggeman, JL and Keil, JE 1975 Sodium fluoroacetate poisoning. American Journal of Diseases of Children 129: 12241226Google ScholarPubMed
Robinson, RF, Griffith, JR, Wolowich, WR and Nahata, MC 2002 Intoxication with sodium monofluoroacetate (compound 1080). Veterinary and Human Toxicology 44: 9395Google ScholarPubMed
Robison, WH 1970 Acute toxicity of sodium monofluoroacetate to cattle. Journal of Wildlife Management 34: 647648CrossRefGoogle Scholar
Saunders, G, Coman, B, Kinnear, J and Braysher, M 1995 Managing Vertebrate Pests: Foxes. Australian Government Publishing Service: Canberra, AustraliaGoogle Scholar
Schultz, RA, Coetzer, JA, Kellerman, TS and Naude, TW 1982 Observations on the clinical, cardiac and histopathological effects of fluoroacetate in sheep. Onderstepoort Journal of Veterinary Research 49: 237245Google ScholarPubMed
Sharp, T and Saunders, G undated Aerial baiting of wild dogs with 1080. Department of Primary Industries: NSW, AustraliaGoogle Scholar
Sherley, M 2004 The traditional categories of fluoroacetate poisoning signs and symptoms belie substantial underlying similarities Toxicology Letters 151: 399406CrossRefGoogle ScholarPubMed
Singer, GG and Brenner, BM 2005 Fluid and Electrolyte Disturbances. In: Kasper, DL, Braunwald, E, Fauci, AS, Hamser, SL, Longo, DL, Jameson, L and Isselbacher, KJ (eds) Harrison's Principles of Internal Medicine, 16th edition. McGraw-Hill: New York, USAGoogle Scholar
Taylor, WM, D'Costa, M, Angel, A and Halperin, ML 1977 Insulin-like effects of fluoroacetate on lipolysis and lipogenesis in adipose tissue. Canadian Journal of Biochemistry 55: 982987CrossRefGoogle ScholarPubMed
Trabes, J, Rason, N and Avrahami, E 1983 Computed tomography demonstration of brain damage due to acute sodium monofluoroacetate poisoning. Journal of Toxicology and Clinical Toxicology 20: 8592Google ScholarPubMed
Twigg, LE 1994 Occurrence of fluoroacetate in Australian plants and tolerance to 1080 in indigenous Australian animals. In: Seawright, AA and Eason, C (eds) Proceedings of the Science Workshop on 1080. Royal Society of New Zealand Miscellaneous Series 28: Wellington, New ZealandGoogle Scholar
Van Polanen Petal, AM, Marks, CA and Morgan, DG 2001 Bait palatability influences the caching behaviour of the red fox (Vulpes vulpes). Wildlife Research 28: 395401CrossRefGoogle Scholar
Ward, AA 1947 Convulsive activity induced by fluoroacetate. Journal of Neurophysiology 10: 105–1 I 1CrossRefGoogle ScholarPubMed
Williams, AT 1948 Sodium fluoroacetate poisoning. Hospital Corps Quarterly 21: 1618Google Scholar
Williams, D 1996 Animal welfare aspects of the use of sodium fluoroacetate to poison wild rabbits. In: Marks, CA and Fisher, PM (eds) Humaneness and Vertebrate Pest Control pp 6264. Ropet Printing: Tynong North, AustraliaGoogle Scholar
Williamson, R and Bloomfield, T 2003 Landcare Notes: 1080 poison baits for pest animal control. State of Victoria, Department of Sustainability and Environment: Victoria, AustraliaGoogle Scholar