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The effect of cimaterol and oestradiol-17β alone or combined on growth and body composition of wether lambs

Published online by Cambridge University Press:  02 September 2010

H. Galbraith ,
P. R. Hatendi ,
E. M. Alderson  and
J. R. Scaife
H. Galbraith
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
P. R. Hatendi
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
E. M. Alderson
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
J. R. Scaife
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
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Abstract

Twenty-four Finn ♂ × Dorset Down ♀ wether lambs about 10 weeks and weighing on average 18 kg were allocated to treatment groups as follows: untreated controls (U); 15 mg oestradiol-17β (OE) implanted subcutaneously (O); cimaterol (2 mg/kg dry matter (DM)) in the diet (C); and 15 mg OE implant + cimaterol (2 mg/kg DM in the diet) (OC). The lambs were offered a diet, restricted to 38 g/kg live weight (LW), and which contained an estimated 12·5 MJ metabolizable energy and 137 g crude protein per kg DM for the experimental period of 62 or 63 days. Comparisons were made for the main effects of OE and cimaterol and also interactions between OE and cimaterol. Treatment with OE, on average, resulted in greater LW gain, DM intake, empty body weight (EBW), body length and chest depth, weight of shoulder and loin joints and carcass crude protein, but had no effect on fat deposition in carcass or depots. As a proportion of EBW, the weights of the pituitary gland and accessory vesicular glands were increased, as was teat length in lambs treated with OE. Cimaterol treatment, on average, increased LW gain, EBW, killing-out ratio, carcass weight and its weight of crude protein and, unlike OE, decreased the weight of the pituitary gland as a proportion of EBW and reduced the weight and proportion of fat in the carcass and perirenal and retroperitoneal depots. Increases in the cross-sectional area of m. longissimus dorsi and in the weight of selected major and minor commercial joints were also obtained in cimaterol-treated lambs. The presence of significant interactions indicated that there was incomplete or no additivity between the effects of cimaterol and OE for LW gain, cross-sectional area of m. longissimus dorsi and weights of carcass and carcass crude protein, omental fat and of certain of the dissected joints. These results suggest either that the mechanisms of action of oestradiol-17β and cimaterol are not independent or that they are affected by similar metabolic or physiological processes which limit the ability of castrated male sheep to exhibit a positive response.

Keywords

carcass compositioncimaterolestradiolgrowthwethers
Type
Research Article
Information
Animal Production , Volume 51 , Issue 2 , October 1990 , pp. 311 - 319
Copyright
Copyright © British Society of Animal Science 1990

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References

REFERENCES

Beermann, D. H., Butler, W. R., Hogue, D. E., Fishell, V. K., Dalrymple, R. H., Ricks, C. A. and Scanes, C. G. 1987. Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs. Journal of Animal Science 65: 1514–1524.Google Scholar
Beermann, D. H., Hogue, D. E., Fishell, V. K., Dalrymple, R. H. and Ricks, C. A. 1986. Effects of cimaterol and fishmeal on performance, carcass characteristics and skeletal muscle growth in lambs. Journal of Animal Science 62: 370–380.Google Scholar
Brown, A. J. and Williams, D. R. 1981. Sheep carcass evaluation — measurements of composition using a standardised butchery method. Memo., Meat Research Institute, Langford, Bristol, No. 38.Google Scholar
Buttery, P. J. 1983. Hormonal control of protein deposition in animals. Proceedings of the Nutrition Society 42: 137–148.CrossRefGoogle ScholarPubMed
Buttery, P. J. and Dawson, J. M. 1987. The mode of action of beta-agonists as manipulators of carcass composition. In Beta-agonists and Their Effects on Animal Growth and Carcass Quality (ed. Hanrahan, J. P.), pp. 29–43. Elsevier Applied Science, London.Google Scholar
Buttery, P. J. and Sinnftt-Smith, P. A. 1984. The mode of action of anabolic agents with special reference to their effects on protein metabolism — some speculations. In Manipulations of Growth in Farm Animals (ed. Roche, J. F. and O'Callaghan, D.), pp. 211–228. Martinus Nijhoff, The Hague.Google Scholar
Coelho, J. F. S., Galbraith, H. and Topps, J. H. 1981. The effect of a combination of trenbolone acetate and oestradiol-17β on growth performance and blood, carcass and body characteristics of wether lambs. Animal Production 32: 261–266.Google Scholar
Galbraith, H., Singh, S. B., Scaihe, J. R. and Henderson, G. D. 1985. Effect of oestrogenic and androgenic compounds on some endocrine and body characteristics of male castrate lambs. Proceedings of the Nutrition Society 44: 94A (Abstr.).Google Scholar
Hanrahan, J. P., Fitzsimons, J. M., McEwen, J. C., Allan, P. and Quirke, J. F. 1987. Effects of the beta-agonist cimaterol on growth, food efficiency and carcass quality in sheep. In Beta-agonists and Their Effects on Animal Growth and Carcass Quality (ed. Hanrahan, J. P.), pp. 106–118. Elsevier Applied Science, London.Google Scholar
Heitzman, R. J. 1986. Safety aspects of growth manipulation in animals. In Control and Manipulation of Animal Growth (ed. Buttery, P. J., Haynes, N. B. and Lindsay, D. B.), pp. 315–330. Butterworths, London.Google Scholar
Hoffman, B. 1987. Introductory remarks in relation to beta-agonists and their effects on growth and carcass quality in farm animals. In Beta-agonists and Their Effects on Animal Growth and Carcass Quality (ed. Hanrahan, J. P.), pp. 1–12. Elsevier Applied Science, London.Google Scholar
Kim, Y. S., Lee, Y. B. and Dalrymple, R. H. 1987. Effect of the repartitioning agent cimaterol on growth, carcass and skeletal muscle characteristics in lambs. Journal of Animal Science 65: 1392–1399.Google Scholar
Lawes Agricultural Trust. 1977. GENSTAT V, Mark 4.01. Rothamsted Experimental Station, Harpenden, Hertfordshire.Google Scholar
MacVinish, L. J. and Galbraith, H. 1988. The effect of implantation of trenbolone acetate and oestradiol-17β in wether lambs at two initial live weights on concentrations of steroidal residues and blood glucose, urea and thyroid hormones. Animal Production 47: 75–85.Google Scholar
Maltin, C. A., Hay, S. A., Delday, N. I., Lobley, G. E. and Reeds, P. J. 1989. The action of the beta-agonist cimaterol on protein metabolism in innervated and denervated phasic muscles. Biochemical Journal 261: 965–971.Google Scholar
O'Connor, R. M., Dwyer, D. A. and Beermann, D. H. 1988. Effects of three-week and six-week cimaterol administration on plasma hormone and glucose concentrations and carcass composition in lambs. Journal of Animal Science 66: Suppl. I, p. 252 (Abstr.).Google Scholar
Reeds, P. J., Hay, S. M., Dorward, P. M. and Palmer, R. H. 1988. The effect of beta-agonists and antagonists on muscle growth and body composition of young rats (Rattus sp.). Comparative Biochemistry and Physiology 89C: 337–341.Google Scholar
Roche, J. F. and Quirke, J. F. 1986. The effects of steroid hormones and xenobiotics on growth of farm animals. In Control and Manipulation of Animal Growth (ed. Buttery, P. J., Haynes, N. B., Lindsay, D. B.), pp. 39–51. Butterworths, London.CrossRefGoogle Scholar
Singh, S. B., Galbraith, H., Scaife, J. R. and Hunter, E. A. 1985. Effect of oestrogenic and androgenic compounds on growth and body composition of male castrate lambs. Proceedings of the Nutrition Society 44: 93A (Abstr.).Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1986. Growth performance and body composition of early weaned wether lambs treated with trenbolone acetate combined with oestradiol-17β. Animal Production 43: 109–114.Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1988. Growth performance and body composition of wether lambs implanted at two different initial live weights with trenbolone acetate combined with oestradiol-17β. Animal Production 47: 65–74.Google Scholar
Thornton, R. F., Tume, R. K., Payne, G., Larsen, T. W., Johnson, G. W. and Hoehenhaus, M. A. 1985. The influence of the (β2-adrenergic agonist, clenbuterol, on lipid metabolism and carcass composition of sheep. Proceedings of the New Zealand Society of Animal Production 43: 97–101.Google Scholar
Timmerman, H. 1987. β-adrenergics: physiology, pharmacology, applications, structures and structure — activity relationships. In Beta-agonists and Their Effects on Animal Growth and Carcass Quality (ed. Hanrahan, J. P.), pp. 13–28. Elsevier Applied Science, London.Google Scholar
Williams, P. E. V., Pagliani, L., Innes, G. M., Pennie, K., Harris, C. I. and Garthwaite, P. 1987. Effects of a β-agonist (clenbuterol) on growth, carcass composition, protein and energy metabolism of veal calves. British Journal of Nutrition 57: 417–428.Google Scholar