Skip to main content Accessibility help

Blood leptin concentrations in Japanese Black cattle

  • T. Tokuda (a1) and H. Yano (a1)


The objective of this study was to examine the changes of serum leptin levels in heifers and steers during fattening. Seven steers and seven heifers at 14 months of age were used in the experiment. Live weight and serum leptin levels were determined at 2-month intervals. Initial live weight was greater in steers than heifers and a similar trend of growth was recorded during the experiment. As a result, live weight was higher in the steers than in the heifers during the experiment. Serum leptin concentration in both groups increased during the experiment and reached optimum level at 22 months of age and did not change thereafter. The increase in serum leptin level was more marked in heifers and leptin level was higher (P < 0·05) in heifers than steers between 18 and 26 months of age. The results suggest that serum leptin level increases during fattening in cattle and the trend is possibly affected by gender.



Hide All
Campfield, L. A., Smith, F. J. and Burn, P. 1996. The OB protein (leptin) pathway – a link between adipose tissue mass and central neural networks. Hormone and Metabolic Research 28: 619632.
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. and Burn, P. 1995. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546549.
Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L. and Considine, R. V. 1996. Leptin: the tale of an obesity gene. Diabetes 45: 14551462.
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L. and Caro, J. F. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine 334: 292295.
Coppack, S. W., Pinkney, J. H. and Mohamed-Ali, V. 1998. Leptin production in human adipose tissue. Proceedings of the Nutrition Society 57: 461470.
Dulphy, J. P., Remond, B. and Theriez, M. 1979. Ingestive behaviour and related activities in ruminants. In Digestive physiology and metabolism in ruminants (ed. Ruckebusch, Y. and Thivend, P.), pp. 103122. MTP Press Limited, England.
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. and Friedman, J. M. 1995. Weight-reducing effects of the plasma-protein encoded by the obese gene. Science 269: 543546.
Havel, P. J., Kasim-Karakas, S., Dubuc, G. R., Mueller, W. and Phinney, S.D. 1996. Gender differences in plasma leptin concentrations. Nature Medicine 2: 949950.
Hoshi, S. and Yamauchi, M. 1990. Kachikurinsyohansyokugaku, pp. 6061. Asakura-shoten Co. Ltd, Tokyo.
Hoshino, T. 1987. [An aspect of fat accumulation.] In Shin Nyugyu no Kagaku (ed. Tsuda, T. and Shibata, F.), pp. 322326. Nousan Gyoson Bunka Kyoukai, Tokyo.
Hosoda, K., Masuzaki, H., Ogawa, Y., Miyawaki, T., Hiraoka, J., Hanaoka, I., Yasuno, A., Nomura, T., Fujisawa, Y., Yoshimasa, Y., Nishi, S., Yamori, Y. and Nakao, K. 1996. Development of radioimmunoassay for human leptin. Biochemical and Biophysical Research Communications 221: 234239.
Houseknecht, K. L., Baile, C. A., Matteri, R. L. and Spurlock, M. E. 1998. The biology of leptin: a review. Journal of Animal Science 76: 14051420.
Jago, J. G., Cox, N. R., Bass, J. J. and Matthews, L. R. 1997. The effect of prepubertal immunization against gonadotropin-releasing hormone on the development of sexual and social behavior of bulls. Journal of Animal Science 75: 26092619.
Jenkins, A. B., Markovic, T. P., Fleury, A. and Campbell, L. V. 1997. Carbohydrate intake and short-term regulation of leptin in humans. Diabetrogia 40: 348351.
Kameoka, K. 1966. [Digestion of feed in the rumen. ] In Nyugyu no Kagaku (ed. Umezu, M.), pp. 241251. Nousan Gyoson Bunka Kyoukai, Tokyo.
Landt, M., Gingerich, R. L., Havel, P. J., Mueller, W. M., Schoner, B. J., Hale, E. and Heiman, M. L. 1998. Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clinical Chemistry 44: 565570.
Luukkaa, V., Pesonen, U., Huhtaniemi, I., Lehtonen, A., Tilvis, R., Tuomilehto, J., Koulu, M. and Huupponen, R. 1998. Inverse correlation between serum testosterone and leptin in men. Journal of Clinical Endocrinology and Metabolism 83: 32433246.
Mantzoros, C. S., Flier, J. S. and Rogol, A. D. 1997. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. Journal of Clinical Endocrinology and Metabolism 82: 10661070.
Minton, J. E., Bindel, D. J., Drouillard, J. S., Titgemeyer, E. C., Grieger, D. M. and Hill, C. M. 1998. Serum leptin is associated with carcass traits in finishing cattle. Journal of Animal Science 76: (suppl. ) 231.
Murakami, T., Iida, M. and Shima, K. 1995. Dexamethasone regulates obese expression in isolated rat adipocytes. Biophysiology Research Communications 214: 12601267.
Ostlund Jr, R. E., Wang, J. W., Klein, S. and Gingerrich, R. 1996. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. Journal of Clinical Endocrinology and Metabolism 81: 39093913.
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Soone, T. and Collins, F. 1995. Effects of the obese gene-product on body-weight regulation in ob/ob mice. Science 269: 540543.
Shimize, H., Shimomura, Y., Nakanishi, Y., Futawatari, T., Ohtani, K., Sato, N. and Mori, M. 1997. Estrogen increases in vivo leptin production in rats and human subjects. Journal of Endocrinology 154: 285292.
Sinha, M. K., Sturis, J., Ohannesian, J., Magosin, S., Stephens, T., Heiman, M. L., Polonsky, K. S. and Caro, J. F. 1996. Ultradian oscillations of leptin secretion in humans. Biochemical and Biophysical Research Communications 228: 733738.
Statistical Analysis Systems Institute. 1985. SAS user’s guide: statistics, version 5 edition. SAS Institute Inc., Cary, NC.
Takahashi, E., Matsui, T., Wakamatsu, S., Yuri, N., Shiojiri, Y., Matsuyama, R., Murakami, H., Tanaka, S., Torii, S. and Yano, H. 1999. [Serum vitamin C concentration in fattening and fattened beef cattle. ] Animal Science Journal 70: J114J118.
Tokuda, T., Matsui, T., Ito, J., Torii, S. and Yano, H. 2000. The changes in body weight and plasma metabolite levels during leptin injection are caused by the reduction of food intake in sheep. Animal Science 70: 343348.
Tokuda, T., Matsui, T. and Yano, H. 1999. Leptin concentrations in the blood of ruminants. Proceedings of the ninth international symposium on ruminant physiology, Pretoria, South Africa, pp. 211212.
Yoneda, N., Saito, S., Kimura, M., Yamada, M., Iida, M., Murakami, T., Irahara, M., Sima, K. and Aono, T. 1998. The influence of ovariectomy on ob gene expression in rats. Hormone and Metabolic Research 30: 263265.
Zhang, Y. Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M. 1994. Positional cloning of the mouse obese gene and its human homolog. Nature 372: 425432.


Blood leptin concentrations in Japanese Black cattle

  • T. Tokuda (a1) and H. Yano (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed