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Variations in liver and blood copper concentrations in young beef cattle raised in north-west Spain: associations with breed, sex, age and season

Published online by Cambridge University Press:  09 March 2007

M. Miranda ,
J. M. Cruz ,
M. López-Alonso  and
J. L. Benedito
M. Miranda*
Affiliation:
Universidade de Santiago de Compostela, Departamento de Ciencias Clínicas Veterinarias, Facultade de Veterinaria, 27002, Lugo, Spain
J. M. Cruz
Affiliation:
Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain
M. López-Alonso
Affiliation:
Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain
J. L. Benedito
Affiliation:
Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain
*
†E-mail: mmiranda@lugo.usc.es
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Abstract

The aim of the present study was to evaluate the influence of breed and other factors (age, sex and season) on copper (Cu) accumulation by calves reared in a region in north-west Spain where pig slurry is widely used for slurry fertilization, and where cattle typically have hepatic Cu concentrations above the generally accepted safe-adequate levels. In December 2000 and August 2001, paired liver and blood samples were obtained at slaughter from 532 male and female Galician Blond, Holstein-Friesian and Galician Blond×Holstein-Friesian calves, aged between 6 and 10 months, from 434 different farms. Samples were acid-digested and Cu concentrations determined by ICP-OES. Holstein-Friesian calves showed significantly higher mean Cu concentrations both in the liver (80·6 mg/kg fresh weight) and blood (0·891 mg/l) than Galician Blond calves (50·4 mg/kg and 0·748 mg/l respectively) and crosses between the two breeds (61·3 mg/kg and 0·829 mg/l respectively). Holstein-Friesian was the breed with the highest percentage (42%) of calves with hepatic Cu concentrations above safe-adequate levels (25 to 100 mg/kg fresh weight) and Galician Blond the breed with the highest proportion (29%) of hypocupraemia during the winter sampling. Considering all breeds, hepatic Cu levels were higher in males (63·8 mg/kg) than in females (53·5 mg/kg) and significantly increased with age in summer. A significant three-way breed×sex×age interaction was observed for liver Cu but this may be attributable to the small number of animals in some groups, having a confounding effect on the analysis. A significant sex×age×season interaction was also observed which could indicate greater male dominance in summer, so that they consume more forage (and thus more Cu) than females. Calves slaughtered in winter showed significantly lower mean blood Cu concentration (0·703 mg/l) than calves slaughtered in summer (0·940 mg/l).

Keywords

agebreed differencescattlecopperseasonal variationsex
Type
Research Article
Information
Animal Science , Volume 82 , Issue 2 , April 2006 , pp. 253 - 258
Copyright
Copyright © British Society of Animal Science 2006

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References

Bidewell, C. A., David, G. P. and Livesey, C. T. 2000. Copper toxicity in cattle. Veterinary Record 147: 399–400.Google ScholarPubMed
Du, Z., Hemken, R. W. and Harmon, R. J. 1996. Copper metabolism of Holstein and Jersey cows and heifers fed diets high in cupric sulphate or copper proteinate. Journal of Dairy Science 79: 1873–1880.CrossRefGoogle ScholarPubMed
Engle, T. E. and Spears, J. W. 2000. Effects of dietary copper concentration and source on performance and copper status of growing and finishing steers. Journal of Animal Science 78: 2446–2451.CrossRefGoogle ScholarPubMed
Gooneratne, S. R., Symonds, H. W., Bailey, J. V. and Christensen, D. A. 1994. Effects of dietary copper, molybdenum and sulphur on biliary copper and zinc excretion in Simmental and Angus cattle. Canadian Journal of Animal Science 74: 315–325.CrossRefGoogle Scholar
Hadrich, J. 1996. High amounts of copper in calf livers. Recent data and estimation of potential health hazards. Deutsche Lebensmittel-Rundschau 92: 103–113.Google Scholar
Jilg, T., Unglaub, W. and Eckstein, B. 1997. Influence of copper supplementation in milk replacers on the copper concentration of calf livers. Fleischwirtschaft 77: 559–562.Google Scholar
Khan, A. T., Diffay, B. C., Datiri, B. C., Forester, D. M., Thompson, S. J. and Mielke, H. W. 1995. Heavy metals in livers and kidneys of goats in Alabama. Bulletin of Environmental Contamination and Toxicology 55: 568–573.CrossRefGoogle ScholarPubMed
Kottferová, J., Koréneková, B. 1997. Comparison of the occurrence of risk elements in bulls and dairy cows coming from the fallout region of a metallurgical plant on the territory of Slovakia. Archives of Animal Breeding 40: 309–316.Google Scholar
Laven, R. A., Livesey, C. T., Offer, N. W. and Fountain, D. 2004. Apparent subclinical hepatophaty due to excess copper intake in lactating Holstein cattle. Veterinary Record 155: 120–121.CrossRefGoogle Scholar
Littledike, E. T., Wittum, T. E. and Jenkins, T. G. 1995. Effect of breed, intake and carcass composition on the status of several macro and trace minerals of adult beef cattle. Journal of Animal Science 73: 2113–2119.CrossRefGoogle ScholarPubMed
Livesey, C. T. 2002. Investigation of copper poisoning in adult cows by veterinary laboratories agency. Cattle Practice 10: 289–294.Google Scholar
López Alonso, M. 1999. Estudio de los principales elementos contaminantes en ganado vacuno de Galicia. Thesis, University of Santiago de Compostela (Spain).Google Scholar
López-Alonso, M., Benedito, J. L., Miranda, M., Castillo, C., Hernández, J. and Shore, R. F. 2000a. Arsenic, cadmium, lead, copper and zinc in cattle from Galicia, NW Spain. Science of the Total Environment 246: 237–248.CrossRefGoogle ScholarPubMed
López-Alonso, M., Benedito, J. L., Miranda, M., Castillo, C., Hernández, J. and Shore, R. F. 2000b. The effect of pig farming on copper and zinc accumulation in cattle in Galicia (North-Western Spain). Veterinary Journal 160: 259–266.CrossRefGoogle ScholarPubMed
López-Alonso, M., Prieto, F., Miranda, M., Castillo, C., Hernández, J. and Benedito, J. L. 2005b. The role of metallothionein and zinc in hepatic copper accumulation in cattle. Veterinary Journal 169: 262–267.CrossRefGoogle ScholarPubMed
Miranda, M., López-Alonso, M., Castillo, C., Hernandez, J. and Benedito, J. L. 2000. Effect of sex on arsenic, cadmium, lead, copper and zinc accumulation in calves. Veterinary and Human Toxicology 42: 265–268.Google ScholarPubMed
Puls, R. 1994. Mineral levels in animal health. Sherpa International, Clearbrook.Google Scholar
Radostits, O. M., Gay, C. C., Blood, D. C. and Hinchcliff, K. W. 2002. Medicina veterinaria. In Tratado de las enfermedades del ganado bovino, ovino, porcino, caprino y equino. McGraw-Hill Interamericana, Madrid.Google Scholar
Statistical Packages for the Social Sciences. 2003. SPSS for Windows, version 12.0. SPSS Inc., Chicago, IL.Google Scholar
Suttle, N. F. 1986. Copper deficiency in ruminants: recent developments. Veterinary Record 119: 519–522.CrossRefGoogle ScholarPubMed
Suttle, N. F. 1993. Overestimation of copper deficiency. Veterinary Record 133: 123–124.CrossRefGoogle ScholarPubMed
Suttle, N. F., Lewis, R. M. and Small, J. N. W. 2002. Effects of breed and family on rate of copper accretion in he liver of purebred Charollais, Suffolk and Texel lambs. Animal Science 75: 295–302.CrossRefGoogle Scholar
Tokarnia, C. H., Dobereiner, J., Peixoto, P. V. and Moraes, S. S. 2000. Outbreak of copper poisoning in cattle fed poultry litter. Veterinary and Human Toxicology 42: 92–95.Google ScholarPubMed
Underwood, E. J. and Suttle, N. F. 1999. The mineral nutrition of livestock, third edition. CAB International, Wallingford.CrossRefGoogle Scholar
Veterinary Laboratories Agency Surveillance Report. 2001. July sees an increased incidence of copper poisoning in cattle. Veterinary Record 149: 257–260.Google Scholar