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BRD treatment failure: clinical and pathologic considerations

Published online by Cambridge University Press:  08 March 2021

T. L. Ollivett Open the ORCID record for T. L. Ollivett [Opens in a new window]
T. L. Ollivett*
Affiliation:
University of Wisconsin-Madison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI53706, USA
*
Author for correspondence: T. L. Ollivett, University of Wisconsin-Madison School of Veterinary Medicine, 2015 Linden Drive, Madison, WI53706, USA. E-mail: theresa.ollivett@wisc.edu
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Abstract

In cattle treated for respiratory disease, resolution of clinical signs has been the mainstay of determining treatment response and treatment efficacy. Through the use of calf lung ultrasound, we have found that pneumonia can persist or recur in the face of antibiotic therapy, despite improved clinical signs, leading to greater risk of clinical disease and more antibiotic use in the future. This review will discuss the pros and cons of using clinical signs to define resolution of disease and discuss how to implement lung ultrasound to improve our ability to accurately measure the impact of antibiotic therapy in cattle with respiratory disease.

Keywords

Antibioticsbovine respiratory diseaselung ultrasound
Type
Special issue: Papers from Bovine Respiratory Disease Symposium
Information
Animal Health Research Reviews , Volume 21 , Issue 2 , December 2020 , pp. 175 - 176
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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References

Binversie, ES, Ruegg, PL, Combs, DK and Ollivett, TL (2020) Randomized clinical trial to assess the effect of antibiotic therapy on health and growth of preweaned dairy calves diagnosed with respiratory disease using respiratory scoring and lung ultrasound. Journal of Dairy Science 103, 11723–11735.CrossRefGoogle ScholarPubMed
Buczinski, S, Forte, G, Francoz, D and Bélanger, A (2014) Comparison of thoracic auscultation, clinical score, and ultrasonography as indicators of bovine respiratory disease in preweaned dairy calves. Journal of Veterinary Internal Medicine 28, 234–242.CrossRefGoogle ScholarPubMed
Buczinski, S, Ollivett, TL and Dendukuri, N (2015) Bayesian estimation of the accuracy of the calf respiratory scoring chart and ultrasonography for the diagnosis of bovine respiratory disease in pre-weaned dairy calves. Preventive Veterinary Medicine 119, 227–231.CrossRefGoogle Scholar
Caswell, JL and Williams, KJ (2016) Chapter 5 Respiratory system. In Maxie, MG (ed.), Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. St. Louis: Elsevier, pp. 465–591.CrossRefGoogle Scholar
Cramer, M and Ollivett, TL (2019) Growth of preweaned, group-housed dairy calves diagnosed with respiratory disease using clinical respiratory scoring and thoracic ultrasound – a cohort study. Journal of Dairy Science 102, 4322–4331.CrossRefGoogle ScholarPubMed
DeDonder, K and Apley, M (2015) A review of the expected effects of antimicrobials in bovine respiratory disease treatment and control using outcomes from published randomized clinical trials with negative controls. Veterinary Clinics of North America – Food Animal 31, 97–111.CrossRefGoogle ScholarPubMed
Dunn, TR, Ollivett, TL, Renaud, DL, Leslie, KE, LeBlanc, SJ, Duffield, TF and Kelton, DF (2018) The effect of lung consolidation, as determined by ultrasonography, on first-lactation milk production in Holstein dairy calves. Journal of Dairy Science 101, 5404–5410.CrossRefGoogle ScholarPubMed
Guardabassi, L, Apley, M, Olsen, JE, Toutain, PL and Weese, S (2018) Chapter 30: Optimization of antimicrobial treatment to minimize resistance selection. In Frank, MA, Stefan, S, Jianzhong, S and Lina, C (eds), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. Washington, DC: American Society of Microbiology, pp. 637–673.CrossRefGoogle Scholar
Heins, B, Nydam, D, Woolums, A, Berghaus, R and Overton, M (2014) Comparative efficacy of enrofloxacin and tulathromycin for treatment of preweaning respiratory disease in dairy heifers. Journal of Dairy Science 97, 372–382.CrossRefGoogle ScholarPubMed
Holschbach, CL, Raabis, SM and Ollivett, TL (2019) Effect of antibiotic treatment in preweaned Holstein calves after experimental bacterial challenge with Pasteurella multocida. Journal of Dairy Science 102, 11359–11369.CrossRefGoogle ScholarPubMed
McGuirk, SM and Peek, SF (2014) Timely diagnosis of dairy calf respiratory disease using a standardized scoring system. Animal Health Research Reviews 15, 145–147.CrossRefGoogle ScholarPubMed
Ollivett, TL and Buczinski, S (2016) On-farm use of ultrasonography for bovine respiratory disease. Veterinary Clinics North America – Food Animal Practice 32, 19–35.CrossRefGoogle ScholarPubMed
Ollivett, T, Hewson, J, Schubotz, R and Caswell, J (2013) Ultrasonographic progression of lung consolidation after experimental infection with Mannheimia haemolytica in Holstein calves. Journal of Veterinary Internal Medicine 27, 673.Google Scholar
Ollivett, TL, Kelton, D, Nydam, DV, Duffield, T, Leslie, KE, Hewson, J and Caswell, J (2015) Thoracic ultrasonography and bronchoalveolar lavage fluid analysis in Holstein calves with subclinical lung lesions. Journal of Veterinary Internal Medicine 29, 1728–1734.CrossRefGoogle ScholarPubMed
Rabeling, B, Rehage, J, Dopfer, D and Scholz, H (1998) Ultrasonographic findings in calves with respiratory disease. Veterinary Record 143, 468–471.CrossRefGoogle ScholarPubMed
USDA (2018) Health and Management Practices on U.S. Dairy Operations, 2014. USDA-APHIS-VS, CEAH, Fort Collins, CO: National Animal Health Monitoring System (NAHMS).Google Scholar
Van Donkersgoed, J, Ribble, CS, Boyer, LG and Townsend, HG (1993) Epidemiological study of enzootic pneumonia in dairy calves in Saskatchewan. Canadian Journal of Veterinary Research 57, 247–254.Google ScholarPubMed
Windeyer, MC, Leslie, KE, Godden, S, Hodgins, DC, Lissemore, KD and LeBlanc, SJ (2012) The effects of viral vaccination of dairy heifer calves on the incidence of respiratory disease, mortality, and growth. Journal of Dairy Science 95, 6731–6739.CrossRefGoogle Scholar