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Twin Studies on Urinary Pepsinogen A Phenotypes and Serum Pepsinogen A Levels

Published online by Cambridge University Press:  01 August 2014

J.C. Pronk*
Affiliation:
Institute of Human Genetics, Amsterdam
D.I. Boomsma
Affiliation:
Department of Experimental Psychology, Amsterdam
G. Pals
Affiliation:
Institute of Human Genetics, Amsterdam Department of Gastroenterology, Free University, Amsterdam
R.R. Frants
Affiliation:
Institute of Human Genetics, Amsterdam
M. Overbeke
Affiliation:
Netherlands Red Cross Blood Bank and Laboratory of Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
S.G.M. Meuwissen
Affiliation:
Department of Gastroenterology, Free University, Amsterdam
J.F. Orlebeke
Affiliation:
Department of Experimental Psychology, Amsterdam
A.W. Eriksson
Affiliation:
Institute of Human Genetics, Amsterdam
*
Institute of Human Genetics, Free University, P.O. Box 7161, 1007 MC Amsterdam, The Netherlands

Abstract

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Urinary pepsinogen A (PGA or PG I) phenotypes and serum PGA levels were studied in MZ and DZ twins and their parents. In 45 out of 48 MZ twin pairs PGA patterns were completely identical, while 3 MZ twin pairs showed minor differences in the relative intensity of the Pg5 isozymogen. This suggests that the intensity of this isozymogen may be influenced by nongenetic factors. There was little difference in the interclass correlations of serum PGA levels between MZ and DZ twins, indicating a large contribution of common environmental factors to serum PGA levels. This is in contrast with previous studies.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1987

References

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