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Twin Azygotic Test for the Study of Hereditary Qualitative Traits in Twin Populations

  • L. Gedda (a1), C. Rossi (a2) and G. Brenci (a1)

Abstract

Following previous formulations of a model of qualitative analysis of twin population data independent of zygosity, a new Bayesian approach has been developed. The present model can be applied to any qualitative genetic trait in twin population data, provided no specific source of variation be introduced by the twin condition, and allows not only estimation of the frequencies of mono- and dizygosity as well as the gene frequencies, but also verification of the trait's mode of inheritance.

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Copyright

Corresponding author

The Mendel Institute, Piazza Galeno 5, 00161 Rome, Italy

References

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1.Allen, G (1955): Comments on the analysis of twin samples. Acta Genet Med Gemellol 4:143160.
2.Allen, G, Hrubec, Z (1979). Twin concordance: A more general model. Acta Genet Med Gemellol 28:313.
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5.Gedda, L, Brenci, G, Rossi, C (1978): Twin models in population genetics. In Nance, WE, Allen, G, Parisi, P (eds): “Twin Research, Part B: Biology and Epidemiology.” Proceedings of the Second International Congress on Twin Studies, Washington 1977. New York: Alan R Liss, pp 149152.
6.Lindley, DV (1971): The estimation of many parameters. In Godambe, VP, Sprott, DA (eds): “Foundations of Statistical Inference.” New York: Holt, Rinehart & Winston.
7.Lindley, DV (1971). Bayesian statistics: A review. SIAM, Regional Conference Series in Applied Mathematics.
8.O'Hagan, A (1976). On posterior joint and marginal modes. Biometrika 63:329333.
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Keywords

Twin Azygotic Test for the Study of Hereditary Qualitative Traits in Twin Populations

  • L. Gedda (a1), C. Rossi (a2) and G. Brenci (a1)

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