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Sulla Regolazione Genetica del Colesterolo Ematico (Uno studio su 50 coppie gemellali MZ e 50 coppie DZ)

  • Luigi Gedda (a1) and Domenico Poggi (a1)

Summary

By dosing the serum-cholesterol in basal conditions in 5 0 MZ (25 ♂ ♂ and 25 ♀ ♀) and 50 DZ (16 ♂ ♂ 18 ♀ ♀ and 16 ♂ ♀ ) twin-pairs, the Authors found an intra-pair dissimilarity significantly different among the pairs of the two zygosity groups. On this basis, the genotypic origin of cholesterol biogenesis is pointed out. The twins, aged from 6 to 19, were all living with their respective families: nutrition and environment were thus the same for each pair.

Riassunto

Dosando il colesterolo serico in condizioni basali sopra 50 coppie MZ (25 ♂ ♂ 25 ♀ ♀) e 50 coppie DZ (16 ♂ ♂, 18 ♀ ♀, 16 ♂ ♀) gli AA. hanno riscontrato uno scarto intrageminale significativamente diverso fra le coppie dei due zigotismi. Su questa base viene sostenuta la dipendenza genotipica delle biogenesi del colesterolo. La regolazione genetica del colesterolo ematico è di alto grado ed appare di tipo autosomico. I gemelli delle coppie studiate, compresi fra 6 e 19 anni, erano tutti conviventi nella rispettiva famiglia d'origine perciò le condizioni alimentari e di ambiente erano le stesse per ciascuna coppia.

RÉSUMÉ

Par le dosage du cholestérol sérique en conditions de base dans 5 0 couples MZ (25 ♂ ♂ et 25 ♀ ♀ ) et 50 couples DZ (16 ♂ ♂ 18 ♀ ♀ et 16 ♂ ♀) les Auteurs ont trouvé un écart intra-couple significativement différent parmi les couples des deux zygotismes. Sur cette base l'on affirme l'origine génotypique de la biogenèse du cholestérol. Les jumeaux des couples étudiés, âgés de 6 à 19 ans, vivaient tous dans leur famille d'origine respective: l'alimentation et le milieu étaient, donc, les mêmes pour chaque couple.

ZUSAMMENFASSUNG

Durch einer Dosierung des Serum-Cholesterins in 50 EZ (25 ♂ ♂ und 25 ♀ ♀) und 50 ZZ (16 ♂ ♂ 18 ♀ ♀ und 16 ♂ ♀) Zwillingspaaren, mit grundsätzlichen Zuständen, haben die Verfassern eine bedeutsame Verschiedenheit zwischen den Partners der EZ und diesen der ZZ Paaren gefunden. Auf diesem Grund, wird die genotypische Ursache der Biogenese des Cholesterins behauptet. Die 6-19järigen untersuchten Zwillinge wohnten alle in ihrer bezüglichen gebürtiger Familie, so waren die Ernährung und die Umwelt die selbste für jeden Paar.

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References

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Autret, M.: Contribution à l'étude des constituants biochimiques du sang de l'Annamite du Tonkin. Thèse de doctorat en Pharmacie, Marseille, 1938.
Arndt, K. D.: Hereditaeres, Kongenitales, familiaeres Xanthom. Zentralbl. f. Haut.Geschlechtskr., 7, 302, 1953.
Arning, E.: Ein fall von familiaerer Xanthomatose. Arch. f. Dermat. Syph., 140, 408, 1910.
Bloom, D., Kaufmann, S. R., Stevens, R. A.: Hereditary Xanthomatosis. Arch, of Derm. Syph., 45, 1, 1942.
Bruins, J. W.: Een Familiaire vorm van Xanthomatosis Tuberosa. Ned. Tydschrift voor Geneeskunde, Jaarg. 97, N. 41, 10 1953.
Cook, R. P.: Cholesterol - Chemistry, Biochemistry, and Pathology. Academic Press Inc. 1958.
Cucurachi, L., Salvi, G.: Influenza dell'associazione sulfanil-urea-mucoproteina gastrica sulla lipidemia dei diabetici. Min. Medica, Vol. XLIX, N. 32, 04 1958.
De Langen, C. D.: Echanges cholestériniques et pathologie de la race. Presse Medicale, 27 juillet 1916, 332333.
De Nicolai, E., Levi, L.: Contributo alla conoscenza della Xantomatosi Ipercolesterinemica idiopatica. Folia Hereditaria et Pathologica, Vol. VIII, Fasc. IV, 10 1959.
Dominici, Giorgio: Le Malattie del Fegato e delle vie biliari. Vol. I-II, Ediz. Vallardi, 1960.
Fasold, A.: Studie über Vererbung von Hautkrankheiten: VI Xanthom (Cholesterosis cutis). Arch. f. Rass. u. Gesdlsch.Biol., 16, 54, 1924.
Fliegelman, M. T., Wilkinson, Ch., Hand, E. A.: Genetics of xantoma tuberosum multiplex. Arch. Dermat. Syph., 58, 409, 1948.
Gallard, H. et al.: Recherches sur le taux de cholestérol sanguin chez le Tonkinois normal ou paludéen. Bull. Soc. Méd. Chir. Indoch., N. 4, 1936.
Garattini, S., Paoletti, R.: Ricerche sulla sintesi del colesterolo e dei lipidi da parte del fegato in diverse condizioni sperimentali. Min. Medica, Vol. XLIX, N. 36, maggio 1958.
Gasq, M.: Constituants biochimiques des Noirs africains en Haute Volta. Rapport N. 3 de la Mission anthropologique de l'A.O.F., Dakar, 1947, 249263.
Gaultier, M.: La valeur fonctionnelle du foie d'après l'analyse du sang et des urines. Loiseleur, (ed.) pp. 784856.
Gee, D. J., Goldstein, J., Gray, C. H., Fowler, J. F.: Biosynthesis of Cholesterol in Familial Hypercholestcrol-aemic Xanthomatosis. British Med. Jour., 09 5, 1959, 341344.
Giambrone, I., Cannada, E., Cacopardo, A., Spina, A.: Variazione del tasso dei lipidi totali, del colesterolo, dei fosfolipidi, del quadro protidemico e dell'azoto incoagulabile del siero in soggetti diabetici trattati con i nuovi ipoglicemizzanti. Min. Medica, Vol. XLIX, N. 32, 04 1958, pp. 15161517.
Girard, Woltz: La cholestérolémie chez les lépreux de Madagascar. Bull. Soc. Pathol. Exot., N. 5, 05 1932.
Grenaud, M.: Les Xanthomes familiaux. Thesis, Paris, 1927.
Heuse, G. A.: Biologie du Noir. Bruxelles, 1957.
Hamburger, F. and Bernfeld, P. The Lipoproteins Methods and Clinical Significance. S. Karger, Basilea 1958.
Hufschmitt, M.: Un cas de xanthome familial. Presse Méd., 32, 99, 1924.
Kleiner, I. S.: Human biochemistry. Londres, Henry Kimpton éd., 1954.
Kritcjevsky, D.: Cholesterol. John Wiley & Sons, Inc., Publishers, 1958.
Lane, G. C., Goodman, J. Jr.: Xantoma tuberosum: Report of familiare occurrence with probable cardiac lesions. Arch. Dermat. a. Syph., 33, 377, 1935.
Lapowski, B.: Familial xanthoma tuberosum multiplex in two sisters. Arch. Dermat a. Syph., 11, 701, 1925.
Lemaire, A., Cottret, J., Loeper, J., Ledermann, S.: Stabilité du cholestérol sérique et athérosclérose. La Presse Méd., 1958, 66, N. 64, 1431.
Morichau, , Beauchan, , Bessonet, : Le xanthome héréditaire et familial. Arch. Gén. de Méd., 192, 2313, 1903.
Mann, G. V. et al.: The beta-lipoprotein and cholesterol concentrations in sera of Nigerians. Brit. Med.J, 22 10 1955, 10081010.
Nepveux, H. W. Fl., Nepveux, P.: Contribution a l'étude de la fonction lipidique dans l'exploration fonctionnelle du Foie chez des Hépatiques Légers. La Presse Méd., 6 juillet 1957, 65, N. 54, 12701271.
Pales, L.: Physiologie comparative des races humaines. Les constituants biochimiques des Noirs soudanais occidentaux transplantés en France. Bull, et Mém. Soc. Anthrop., Paris, 6: 1945, 1561.
Pautrier, M., Levy, G.: Trois cas de Xanthomes en serie familiale, avec infiltrations xanthomateuses tendineuses et juxtaarticulaires et hypercholestérinemie sanguine considérable. La Press, méd., 31, 728, 1923.
Raso, M., Maschio, C., Rigoli, E.: Colesterinosi vascolare cerebrotendinea (sindrome di V. Borgaert-Scherer-Epstein) e infarto cardiaco. Min. Medica, Vol. XLVIII, N. 80, 33043305, 10 1957.
Schaefer, L. E., Adelersberg, D., Steinberg, A. G.: Heredity, Environment, and Serum Cholesterol. A Study of 201 Healthy Families. Circulation, Vol. XVII, N. 4, 04 1958, 537542.
Schaefer, L. R., Adlersberg, D., Steinberg, A.: Serum Phospholipids - Genetic and Environmental Influences. Circulation, Vol. XVIII, N. 3, 09 1958, 341347.
Stone, W.: The blood chemistry of normal Southern Rhodesian natives. Trans. Royal Soc. Trop. Med. and Hyg., 30: 1936, 165172.
Thannhauser, S. J., Schmidt, G.: Lipids and Lipidoses. Physiol. Tev., 26, 275, 1946.
Toeroek, L.: De la nature des xanthomes (avec qualques critiques sur la nature des tumeurs). Ann. de Dermat. et Syph., 4, 1109, 1893.
Touraine, A.: Génétique des dyslipoïdoses. Ann. Derm. Syph., 78, 221, 1943.
Walter, H., Nepveux, FL. et Nepveux, P.: Contribution a l'étude de la fonction lipidique dans l'exploration fonctionnelle du foie chez des hépatiques légers. Presse Médicale, N. 54, Juillet 1957, pp. 12701271.
Waris, E.: Studies on serum lipids and lipoproteins in Hypertension. Acta Med. Scandinavica, Suppl. 337, Vol. 161, 1958.
Wootton, I. D. P., Kling, E. J.: Normal values for blood constituents. Inter-hospital differences. Lancet, 7 03 1953. 470471.

Sulla Regolazione Genetica del Colesterolo Ematico (Uno studio su 50 coppie gemellali MZ e 50 coppie DZ)

  • Luigi Gedda (a1) and Domenico Poggi (a1)

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