No CrossRef data available.
Article contents
The Selectivity of Effectiveness of Cytostatic Agents
Published online by Cambridge University Press: 01 August 2014
Summary
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
The selectivity of cytostatic action depends of the following factors:
a) the compound, its mode of action, the applied dosage, the localization and the speed of activation, its metabolites and excretion;
b) the sensitivity or resistance of the proliferated tissue;
c) the individual general condition of the patient, the degree of malnutrition, the integrity of defense mechanisms and the ability of detoxication and the regenerative capacity of hemopoiesis.
The action of cytostatic agents directed against specific cell functions of different cell systems develops distinct differences in clinical effects and toxicity among alkylating agents, antimetabolites and mitotic inhibitors. Comparative data of these compounds are given. Due to its selectivity of action each cytostatic agent possesses a specific optimal indication in hemoblastoses, neoplasias or immune reactions.
- Type
- Research Article
- Information
- Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 283 - 291
- Copyright
- Copyright © The International Society for Twin Studies 1968
References
Gerhartz, H. (1961) Krebsforschung und Krebsbekämpfung. IV. Strahlenther. Sdb., 48: 126.Google Scholar
Gerhartz, H. (1964). In
Plattner, P.A.: Chemotherapy of Cancer. Intern. Symp., Lugano 1964, 62: 296; Elsevier, Amsterdam.Google Scholar
Karnofsky, D. A. (1964). In
Plattner, P. A.: Chemotherapy of Cancer. Intern. Symp., Lugano 1964, 3: Elsevier, Amsterdam.Google Scholar
Kessel, M.
et al. (1965). Antimicrobial agents and chemotherapy. Proceed. IV Intern. Congr. Chemother., Washington, 518.Google Scholar
You have
Access