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Ricerche statistiche e genetiche sulle malformazioni congenite

Published online by Cambridge University Press:  01 August 2014

P. E. Beolchini
P. E. Beolchini*
Affiliation:
Centro di Studi di Genetica Umana, dell'Università di Milano Istituto Provinciale di Maternità, di Milano

Summary

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After a synthetic review of the literature, the Author reports the results of his statistical researches on the parental age of 739 congenitally malformed children born, from 1942 to 1957, at the Istituto Provinciale di Maternità of Milan.

Concerning the mongolism it seems proved the influence of some particular factors correlated with the maternal age, while on the contrary the paternal age and the birth-order seem to have no influence. About the other malformations examined in this research the parental age and the birth-order appear without relevance.

Riassunto

RIASSUNTO

Dopo una rassegna sintetica della letteratura, l'Autore illustra i risultati della indagine statistica da lui condotta sull'età dei genitori di 739 neonati con malformazioni congenite, nati all'Istituto Provinciale di Maternità di Milano dal 1942 al 1957.

Per la comparsa del mongolismo sembra accertato l'intervento di particolari fattori correlati con l'età materna, mentre nessuna importanza sembra si debba attribuire all'età dei padri ed all'ordine di genitura. Per le altre malformazioni considerate nella ricerca non è stato messo in luce alcun rapporto nè con l'età dei genitori nè con l'ordine di genitura.

Résumé

RÉSUMÉ

L'Auteur, après un aperçu sinthétique de la littérature, rapporte les résultats des ses recherches sur l'âge des parents de 739 enfants atteints par des malformations congénitales, nés entre 1942 et 1957 à l'Istituto Provinciale di Maternità de Milan.

Quant à l'apparition du mongolisme il semble certifié l'influence de certains facteurs en rapport avec l'âge maternelle tandis qu'on ne peut attribuer aucune influence à l'âge des pères et à l'ordre de naissance.

Pour les autres malformations considérées dans cette recherche on n'a relevé aucune relation avec l'âge des parents ou l'ordre de naissance.

Zusammenfassung

ZUSAMMENFASSUNG

Nach einer synthetischen Uebersicht der Literatur erläutert der Verfasser die Ergebnisse der von ihm durchgeführten statistischen Forschung über das Alter der Eltern von 739 Kindern, die mit angeborenen Missgestaltungen in den Jahren von 1942 bis 1957 im «Istituto Provinciale di Maternità» in Mailand geboren wurden.

Was die Mongolismus-Erscheinungen betrifft, scheinen besondere Faktoren im Verhältniss mit dem Alter der Mutter dazu beigetraten zu haben, dagegen spielt das Alter der Väter und die Geburtsfolge keine Rolle. Für die weiteren, in den Forschungen berücksichtigten, Missgestaltungen steht das Alter und die Geburtsfolge in keiner Beziehung dazu.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 8 , Issue 4 , October 1959 , pp. 493 - 510
Copyright
Copyright © The International Society for Twin Studies 1959

References

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