Hostname: page-component-77c89778f8-9q27g Total loading time: 0 Render date: 2024-07-19T02:01:53.089Z Has data issue: false hasContentIssue false
  • English
  • Français

Quantitative Estimates of ABH Secretion in Saliva of Human Twins

Published online by Cambridge University Press:  01 August 2014

K. Sharma  and
S. Sharma
K. Sharma*
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
S. Sharma
Affiliation:
Department of Anthropology, Panjab University, Chandigarh, India
*
Department of Anthropology, Panjab University, Chandigarh – 160014India

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Blood and saliva samples of 122 like-sexed twin pairs (65 MZ and 57 DZ) living in Chandigarh (India) were analyzed for ABH polymorphism. The results indicated that ABH secretions were independent of ABO blood groups though there was an indication of higher incidence of non-secretors among ‘O’ blood group twin individuals. No significant differences were observed between twins and singletons in secretor gene frequency estimates. The quantitative data revealed that mean titre scores for H substances were lower than that for A and B substances. F test contrasting intra-pair variance between zygosities for ABH quantitative secretions was highly significant indicating stronger genetic component of variation. The results suggested that quantitative assay of ABH secretions would be a better indicator for zygosity determination than mere qualitative differentiation.

Keywords

ABH polymorphismSalivaZygosity diagnosisTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 47 , Issue 2 , April 1998 , pp. 115 - 123
Copyright
Copyright © The International Society for Twin Studies 1998

References

REFERENCES

1.Agrawal, S, Bhalla, V (1981): Serological differences among three north Indian caste groups. Ind J Phys Anthropol Hum Genet 7: 135–146.Google Scholar
2.Bhalla, V (1990): ABH polymorphism and lectins in diet: A selection-relaxation hypothesis. In Kocourek, J (ed): Lectins Biology, Biochemistry, Clinical Biochemistry. Vol. 7. St Louis: Sigma Chemical Co. Pp. 299–303.Google Scholar
3.Bhatia, HM, Randeria, KJ (1970): Studies on blood group antigens in saliva: Incidence and type of aberrant secretors. Indian J Med Res 58: 194.Google ScholarPubMed
4.Bhatnagar, DP (1967): A study of blood groups and secretor factor among the Jat and Khatri Sikhs of Chandigarh (Punjab). M.Sc. dissertation (unpublished). Chandigarh: Panjab University.Google Scholar
5.Boklage, CE (1984): Differences in protocols of craniofacial development related to twinship and zygosity. J Craniofac Genet Dev Biol 4: 151–169.Google Scholar
6.Boklage, CE (1995): The frequency and survived probability of natural twin conceptions. In Keith, LG, Papiernik, E, Keith, DM, Luke, B (eds): Multiple Pregnancy; Epidemiology, Gestation and Perinatal Outcome. New York: The Parthenon.Google Scholar
7.Chaudhary, A, Das-Adhikary, CR (1978): Possible role of blood group secretory substances in the aetiology of cholera. R Soc Trop Med Hyg Trans 72: 664–665.Google Scholar
8.Collier, A, Patrick, AW, Toft, AD, Blackwell, CC, James, V, Weir, DM (1988): Increased prevalence of non-secretors in patients with Grave disease: Evidence for an infective aetiology? Brit Med J 296: 1162.Google Scholar
9.Gardas, A, Koscielak, J (1971): AB and H blood group specificities in glycoprotein and glycol-ipid fractions of human erythrocyte membrane; Absence of blood group active glycoprotein in the membranes of non-secretors. Vox Sanguinis 20: 137.Google Scholar
10.Hartman, G (1941): Group antigens in human organs. Copenhagen: Munksgaard.Google Scholar
11.Kinane, DF, Blackwell, CG, Brettle, RP, Weir, DM, Winstanley, FP, Elton, RA (1982): ABO blood group, secretor state and susceptibility of urinary tract infection in women. Brit Med J 285: 7–9.Google Scholar
12.Kumazaki, T, Yoshida, A (1984): Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase. Proc Natl Acad Sci USA 81: 4193–4197.CrossRefGoogle ScholarPubMed
13.Larsen, RD, Ernst, LK, Nair, RP, Lowe, JB (1990): Molecular cloning sequence, and expression of human GDPI fucose: ß-D-galactoside 2-α-fucasyltransferase cDNA that can form the H group antigen. Proc Natl Acad Sci USA 87: 6674–6678.Google Scholar
14.Livingstone, JE, Poland, BJ (1980): A study of spontaneously aborted twins. Teratology 21: 139–148.Google Scholar
15.Me Neil, C, Trentelman, EF, Kreutzer, VO, Fullmer, CD (1957): Aberrant secretion of salivary AB and H group substances in human beings. Am J Clin Path 28: 145.Google Scholar
16.Moore, BPL (1980): Serological and immunological methods. The Canadian Red Cross Society Publication.Google Scholar
17.Mourant, AE (1976): Distribution of the Human Blood Groups & other Polymorphism, 2nd ed. London: Oxford University Press, 1055 P.Google Scholar
18.Oriol, R, Danilovs, J, Hawkins, BR (1981): A new genetic model proposing that the Se gene is a structural gene closely linked to the H gene. Am J Hum Genet 33: 421–431.Google Scholar
19.Post, RH (1962): Population differences in red and green color vision deficiency: a review and a query on selection relaxation. Engenics Quart 9: 131–146.CrossRefGoogle Scholar
20.Pratibha, N, Padma, T, Murty, JS (1995): ABO blood group antibodies and ABH secretion in duodenal ulcers. Ind J Hum Genet 1: 71–75.Google Scholar
21.Pringle, R, Word, AJ, Green, CA (1964): The significance of ABO blood groups and secretor status in duodenal ulcers. Brit J Surg 51: 341–343.CrossRefGoogle Scholar
22.Randhawa, S (1991): ABH Secretion in Health and Disease. Ph.D. Thesis (unpublished), Panjab University, Chandigarh.Google Scholar
23.Rouquier, S, Lowe, JB, Kelly, RJ, Fertitta, AL, Lennon, GG, Giorgi, D (1995): Molecular cloning of a human genomic region containing the H blood group a (1, 2) fucosyltransferase gene and two H locus-related DNA restriction fragments; isolation of a candidate for the human secretor blood group locus. J Biol Chem 270: 4632–4639.Google Scholar
24.Schiff, F, Sasaki, H (1932): Der ausscheidungs typus ein auf serologischem vege nachweisbares Mendelendes Merkmel. Klin Wscher II: 1426–1429.Google Scholar
25.Sharma, K (1986): Higher risk of epilepsy in twins. Ind J Pediatr 53: 415–419.CrossRefGoogle ScholarPubMed
26.Sharma, K (1987): Genetic variance estimates and familial resemblance for body size traits. Acta Genet Med Gemellol 37: 549–555.Google Scholar
27.Sharma, K (1987): Incidence of double occipital hair whors in twins and singletons. Acta Genet Med Gemellol 37: 557–558.Google Scholar
28.Sharma, K (1988): Estimates of genetic variance, heritability and familial resemblance for body compostion traits. Int J Anthropol 3: 361–366.Google Scholar
29.Sharma, K, Corruccini, RS (1986): Odontometric variations of permanent crown in Punjabi and U.S. twins. J Craniofac Genet Develop Biol 6: 325–330.Google Scholar
30.Sheppard, PM (1953): Cancer of stomach and ABO blood groups. Brit Med J I: 1220.Google Scholar
31.Singh, KS, Bhalla, V, Kaul, V (1994): The Biological variations in Indian Populations. Delhi: Oxford University Press, 308–318.Google Scholar
32.Wallace, J, Peebles-Brown, DA, Cook, IA, Metrose, AG (1958): The secretor status in duodenal ulcer patients. Scot Med J 3: 105–109.Google Scholar
33.Yamakami, K (1926): The individuality of semen with reference to its property of inhibiting specifically isohaemagglutination. J Immunol 12: 185.Google Scholar