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The Inheritance of Plasma and Red Blood Cell Magnesium and Zinc Levels Studied From Twin and Family Data

  • P. Darlu (a1), Y. Michotte (a2), E. Defrise-Gussenhoven (a3) and J.G. Henrotte (a1)

Abstract

The variability of magnesium and zinc concentrations in plasma and erythrocytes was investigated by twin and family studies. Twins were sampled in two distinct ways and in two different West-European regions. In one of the samples, a distinction was made between twins living together and twins living apart. Two series of families were studied, one in a homogeneous environment, the other in a more diverse environment. Samples were compared by variance analysis. The results show 1) that genetic variability is significant for red blood cell (RBC) magnesium and zinc, minor for plasma magnesium and absent for plasma zinc; 2) that the family environment affects the extent of resemblance between twins and between siblings more for plasma levels than for RBC levels of magnesium and zinc. Furthermore, the intercorrelation analysis suggests that the genetic regulation systems of RBC magnesium and zinc are different, whereas some of the environmental regulation systems of plasma magnesium and zinc are the same. Biological interpretations are brought forward and discussed.

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Corresponding author

RCP Magnésium et Oligoéléments, Faculté de Pharmacie, 4 avenue de l'Observatoire, 75006 Paris, France

References

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1.Darlu, P (1975): Influences des facteurs météorologiques sur la variabilité de la magnésémie chez l'homme. Int J Biometeorol 19:166173.
2.Darlu, P (1981): Essai d'interprétation génétique et mésologique de la variabilité du métabolisme minéral chez l'homme. Thèse d'Etat, Université Paris VII. Paris.
3.Darlu, P, Henrotte, JG (1976): Is there a genetic control in red blood cell magnesium levels? Biochem System Ecol 4:227229.
4.Darlu, P, Henrotte, J (1980): The importance of genetic and constitutional factors in human red blood cell magnesium control. In Cantin, M, Seelig, MS (eds): “Magnesium in Health and Disease.” Spectrum Publication.
5.Darlu, P, Moreau, Th (1978): Twin studies of blood ionic content. In Nance, WE, Allen, G, Parisi, P (eds): “Twin Research: Part C, Clinical Studies.” New York: Alan R. Liss, pp 177185.
6.Defrise-Gussenhoven, E, Michotte, Y, Susanne, C, Brocteur, J, Hoste, J (1980): Are distances between DZ twins for polygenes and major genes correlated. Paper presented at the 3° International Congress on Twin Studies, Jerusalem.
7.Dorus, E, Pandey, GN, Davis, JM (1975): Genetic determinant of lithium ion distribution: an in vitro and in vivo monozygotic-dizygotic twin study. Arch Gen Psychiatry 32:10971102.
8.Dunn, NJ, Walser, M (1966): Magnesium depletion of normal man. Metabolism 10:884895.
9.Fernet, P, Jacquard, A, Jakobi, L (1975): Mariages et filiations dans la valée pyrénéenne de l'Ouzom depuis 1744.
10.Franck-Riquer, G, Santarromana, M, Henrotte, JG (1980): Etude méthodologique du dosage du Magnesium et du Zinc erythrocytaire et plasmatique par spectrophotométrie d'absorption atomique. Ann Biol Clin (in press).
11.Frithz, G, Ronquist, G (1979): Increased red cell content of zinc in essential hypertension. Acta Med Scand 207:647649.
12.Garay, RP, Meyer, P (1979): Mise en evidence d'anomalies des flux nets de sodium et de potassium dans les érythrocytes de sujets atteints d'hypertension artérielle essentielle. CR Acad Sci (D) 288:453455.
13.Garay, RP, Meyer, P (1979): A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients. Lancet 1:349353.
14.Gilman, JG, Brewer, GJ (1978): The oxygen-linked zinc-binding site of human hemoglobine. Biochem J 169:625632.
15.Henrotte, JG (1968): Le taux de magnésium érythrocytaire et plasmatique chez les mélanodermes. Biometrie Hum 3:9496.
16.Henrotte, JG (1973): Variabilité de la magnésémie des populations humaines. Bilan des recherches. J Physiol 67:197A.
17.Henrotte, JG (1980): The variability of human blood cell magnesium level according to HLA groups. Tissue Antigens 15:419430.
18.Henrotte, JG, Constans, H, Constans, J, Bisseliches, F, Coudert, J (1972): Le magnésium érythrocytaire et plasmatique des populations amérindiennes du Corridor Interandin. Arch Int Physiol Biochem 80:941944.
19.Henrotte, JG, Darlu, P, Pineau, M (1976): Etude de la variabilité du magnésium et du zinc dans les érythrocytes, le plasma et le sérum. Biométrie Hum 11:1525.
20.Henrotte, JG, Poujol, A, Darlu, P, Jaeger, G (1969): Le taux de magnésium érythrocytaire chez les Merina originaires des Hauts Plateaux Malgaches. Biométrie Hum 4:5660.
21.Jasper, P, Silver, S (1980): Magnesium active transport systems of bacterial cells. In Cantin, M, Seelig, MS (eds): “Magnesium in Health and Disease.” Spectrum Publication.
22.Kempthorne, O, Tandon, OB (1953): The estimation of heritability by regression of offspring on parent. Biometrics 9:90100.
23.Kruckeberg, WC, Brewer, GJ (1978): The mechanism and control of human erythrocyte zinc uptake. Med Biol 58:510.
24.Park, MH, Wong, BD, Lusk, JE (1976): Mutants in three genes affecting transport of magnesium in Escherichia coli: Genetics and physiology. J Bacteriol 126:10961103.
25.Schmetterer, G (1978): ATP dependent uptake of zinc by human erythrocyte ghosts. Z Naturforsch (C) 33:210215.
26.Smith, JC, Zeller, JA, Brown, ED, Ong, SC (1976): Elevated plasma zinc: A heritable anomaly. Science 193:496498.
27.Watson, WS, Hilditch, TE, Horton, PW, Davies, DL, Lindsay, R (1979): Magnesium metabolism in blood and the whole body in man using 28 magnesium. Metabolism 28:9095.

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