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Heritability Study on Size of the Physiologic Cup of the Optic Nerve Head - A Summary Report

Published online by Cambridge University Press:  01 August 2014

J. T. Schwartz ,
F. H. Reuling  and
M. Feinleib
J. T. Schwartz*
Affiliation:
National Eye Institute, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Maryland, USA
F. H. Reuling
Affiliation:
National Eye Institute, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Maryland, USA
M. Feinleib
Affiliation:
National Heart and Lung Institute, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Maryland, USA
*
18000 Marden Lane, Sandy Springs, Maryland 20860, USA

Abstract

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Cupping of the optic nerve head is regarded as one of a triad of diagnostic signs associated with glaucoma. This study was undertaken to assess the role of genetic factors in determining size of the physiologic cup of the normal optic nerve head, as measured by a horizontal cup/disc ratio. This is important to our ultimate understanding of the determinants of pathologic change. Horizontal cup/disc ratio was estimated in a sample of 37 MZ and 26 like-sex DZ twin pairs aged 15 years and older. Differences between MZ and DZ samples with respect to intrapair variance and intraclass correlation coefficient were highly significant. This finding of high heritability for measurements of cup diameter is in contrast to low heritability estimates found in a companion investigation on heritability of the effect of corticosteroids on intraocular pressure.

Type
5. Twin Studies in Human Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 181 - 186
Copyright
Copyright © The International Society for Twin Studies 1976

References

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