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Hereditary deficiency in pseudo-cholineslerase and apnoea from succinylcholine

  • G. Sansone (a1) and A. Rasore-Quartino (a1)

Summary

After a brief introduction on the genetic aspects of serum Cholinesterase, the Authors describe two familial cases of subjects homozygous for the atypical gene of Cholinesterase, who had severe apnoea following anesthesia.

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References

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Evans, F. T., et al. (1952). Sensitivity to succinylcholine in relation to pseudo-cholinesterase. Lancet, 1: 1229.
Harris, H. (1964). The genetics of serum Cholinesterase « deficiency » in relation to suxamethonium apnoea. Proc. Roy. Soc. Med., 57: 503.
Harris, H. Whittaker, M. (1961). Differential inibition of human serum Cholinesterase with fluoride: recognition of two new phenotypes. Nature, 191: 496.
Kalow, W. (1962). Pharmacogenetics. Heredity and the Response to Drugs. W. B. Saunders C.
Lehmann, H., Ryan, E. (1956). The familial incidence of low pseudo-cholinesterase level. Lancet, 11: 124.
Lehmann, H., Ryan, E. et al. (1962). Genetical and chemical aspects of the Cholinesterase types. Proc. Sec. Intern. Congr. Hum. Genet., Roma.
Sansone, G. (1963). Malattie metaboliche genotipiche da deficienza enzimatica. In Gedda, L.: De Genetica Medica, IV, 1. Ed. 1st. Mendel. Roma.
Simpson, N. E., Kalow, W. (1964). The « silent » gene for serum Cholinesterase. Amer. J. Hum. Genet., 16: 180.

Hereditary deficiency in pseudo-cholineslerase and apnoea from succinylcholine

  • G. Sansone (a1) and A. Rasore-Quartino (a1)

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