Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-26T10:58:08.566Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic Aspects of Childhood Tumours

Published online by Cambridge University Press:  01 August 2014

J. François ,
S. De Bie  and
M. Matton
J. François*
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
S. De Bie
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
M. Matton
Affiliation:
Division of Medical Genetics, Ophthalmological Clinic, University of Ghent, Belgium
*
Ophthalmological Clinic, University Hospital, De Pintelaan 135, B 9000 Ghent, Belgium

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Present concepts on the etiology of childhood tumours are reviewed. The differences in clinical manifestations of the hereditary and nonhereditary types are illustrated with data on retinoblastoma and on nephroblastoma. Notwithstanding these differences it is most likely that the fundamental etiologic process is the same in both and that it consists in successive mutational events. The possible consequences of the association of retinoblastoma with a deletion of chromosome 13 in some cases are discussed. Several explanations for the association of Wilms' tumour and aniridia are also discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 145 - 149
Copyright
Copyright © The International Society for Twin Studies 1975

References

REFERENCES

Brusa, P., Torricelli, C. 1953. Nefroblastoma di Wilms ed affezioni renali congenite nella casistica dell'I.P.A.I. di Milano. Minerva Pediatr., 5: 457–463.Google Scholar
Di George, A.M., Harley, R.D. 1966. The association of aniridia, Wilms' tumor, and genital abnormalities. Arch Ophthalmol., 75: 796–798.Google Scholar
Faure, C., Lange, J.Cl. 1967. Néphroblastoma et aniridie. Ann. Radiol., 10: 555–557.Google Scholar
Fialkow, P.J., Gartler, S.M., Yoshida, A. 1967. Clonal origin of chronic myelocytic leukemia in man. Proc. Natl. Acad. Sci. U.S.A., 58: 1468–1471.Google Scholar
Fialkow, P.J., Klein, G., Gartler, S.M., Clifford, P. 1970. Clonal origin for individual Burkitt tumors. Lancet, 1: 384–386.CrossRefGoogle Scholar
Fialkow, P.J. 1972. Use of genetic markers to study cellular origin and development of tumors in human females. Adv. Cancer Res., 15: 191–226.Google Scholar
Flanagan, J.C., Di George, A.M. 1969. Sporadic aniridia and Wilms' tumor. Am. J. Ophthalmol., 67: 558–561.Google Scholar
Fontana, V.J., Ferrara, A., Perciaccante, R. 1965. Wilms' tumor and associated anomalies. Am. J. Dis. Child., 109: 459–461.Google Scholar
Fraumeni, J.P., Glass, A.G. 1968. Wilms' tumor and congenital aniridia. JAMA, 206: 825–828.Google Scholar
Fraumeni, J.F. 1969. The aniridia-Wilms' tumor syndrome. The clinical delineation of birth defects. II. Malformation syndromes. New York National Foundation, 198–201.Google Scholar
Gandhi, R.K., Deshmukh, S.S., Waingankar, V.S. 1970. Wilms' tumor with aniridia. J. Pediatr. Surg., 5: 571.Google Scholar
Gey, W. 1970. Dq-, multiple Missbildungen und Retinoblastom. Humangenetik, 10: 362–365.Google Scholar
Grace, E., Drennan, J., Colver, D., Gordon, R.R. 1971. The 13q- deletion syndrome. J. Med. Genet., 8: 351–357.Google Scholar
Haicken, B.N., Miller, D.R. 1971. Simultaneous occurrence of congenital aniridia, hamartoma, and Wilms' tumor. J. Pediatr., 78: 497–502.Google Scholar
Hamerton, J.L. 1971. Cytogenetics (Vol. I). New York and London: Academic Press.Google Scholar
Knudson, A.G. 1971. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 68: 820–823.Google Scholar
Knudson, A.G., Strong, L.C. 1972. Mutation and cancer: a model for Wilms' tumor of the kidney. J. Natl. Cancer Inst., 48: 313–324.Google Scholar
Knudson, A.G., Strong, L.C., Anderson, D.E. 1973. Heredity and cancer in man. In Steinberg, A.G. and Bearn, A.G. (eds.): Progress in Medical Genetics (Vol. 9, pp. 113–158). New York-London.Google Scholar
Ladda, R., Atkins, L., Littlefield, J., Neurath, P., Marimuthu, K.M. 1974. Computer-assisted analysis of chromosomal abnormalities: detection of a deletion in anidria/Wilms' tumor syndrome. Science, 185: 784–787.CrossRefGoogle ScholarPubMed
Ledlie, E.M., Mynors, L.S., Draper, G.J. et al. 1970. Natural history and treatment of Wilms' tumour: An analysis of 335 cases occurring in England and Wales 1962-66. Br. Med. J., 4: 195–200.CrossRefGoogle Scholar
Lele, K.P., Penrose, L.S., Stallard, H.B. 1963. Chromosome deletion in a case of retinoblastoma. Ann. Hum. Genet., 27: 171–174.Google Scholar
Le Marec, B., Lautridou, A., Urvoy, M., Renault, A., Fonlupt, J., Dary, J., Ardouin, M., Coutel, Y. 1971. Un cas d'association de néphroblastoma avec aniridie et malformations génitales. Arch. Fr. Pediatr., 28: 457.Google Scholar
Linder, D., Gartler, S.M. 1965. Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomatas. Science, 150: 67–69.Google Scholar
Lyon, M.F. 1962. Sex chromatin and gene action in the mammalian X-chromosome. Am. J. Hum. Genet., 14: 135–148.Google Scholar
Mackintosh, T.F., Girdwood, T.G., Parker, D.J. et al. 1968. Aniridia and Wilms' tumou (nephroblastoma). Br. J. Ophthalmol., 52: 846–848.CrossRefGoogle Scholar
Miller, R.W., Fraumeni, J.F. Jr., Manning, M.D. 1964. Association of Wilms's tumor with aniridia, hemihypertrophy and other congenital malformations. N. Engl. J. Med., 270: 922–927.CrossRefGoogle ScholarPubMed
Miller, R.W. 1969. Childhood cancer and congenital defects. A study of U.S. death certificates during the period 1960-1966. Pediatr. Res., 3: 389–397.CrossRefGoogle ScholarPubMed
Murray, R.F., Hobbs, J., Payne, B. 1971. Possible clonal origin of common warts (Verruca vulgaris). Nature, 232: 51.Google Scholar
Neidhardt, M. 1972. Wilms' tumor and aniridia. A genetically determined syndrome. Klin. Paediatr., 184: 312–317.Google Scholar
Orye, E., Delbeke, M.J., Vandenabeele, B. 1971. Retinoblastoma and D-chromosome deletions. Lancet, 2: 1376.CrossRefGoogle ScholarPubMed
Orye, E., Delbeke, M.J., Vandenabeele, B. 1974. Retinoblastoma and long arm deletion of chromosome 13. Attempts to define the deleted segment. Clin. Genet., 5: 457–464.Google Scholar
Schweisguth, O., Campinchi, R., Pivoteau, B., Lemerle, J. 1967. L'association aniridie-tumeur du rein chez l'enfant. A propos de 4 cas. Bull. Soc. Ophtalmol. Fr., 67: 1099–1107.Google Scholar
Taylor, A.I. 1970. Dq-, Dr and retinoblastoma. Humangenetik, 10: 209–217.Google ScholarPubMed
Thompson, H., Lyons, R.B. 1965. Retinoblastoma and multiple congenital anomalies associated with complex mosaicism with deletion of D chromosome and probable D/G translocation. Hum. Chrom. Newsl., 15: 21.Google Scholar
Van Kempen, C. 1966. A case of retinoblastoma, combined with severe mental retardation and a few other congenital anomalies, associated with complex aberrations of the karyotype. Maandschr. Kindergeneeskd., 34: 92–95.Google Scholar
Van Kempen, C. 1969. Vijf vormen van autosomale deletie. Een klinische en cytogenetische studie. Doctoral Thesis, University of Nijmegen.Google Scholar
Wilson, M.G., Melnyk, J., Towner, J.W. 1969. Ret-inoblastoma and deletion D(14) syndrome. J. Med. Genet., 6: 322–327.Google Scholar
Wilson, M.G., Towner, J.W., Fujimoto, 1973. Ret-inoblastoma and D chromosome deletions. Am. J. Hum. Genet., 25: 57–61.Google Scholar
Woodard, J.R., Levine, M.K. 1969. Nephroblastoma (Wilms' tumor) and congenital aniridia. J. Urol., 101: 140–143.Google Scholar
Yoneda, C., Van Herrick, W. 1963. Tissue culture cellstrain derived from retinoblastoma. Am. J. Ophthalmol., 55: 987.Google Scholar
Zimmerman, L.E., Font, R.L. 1966. Congenital malformations of the eye. Some recent advances in knowledge of the pathogenesis and histopathological characteristics. JAMA, 196: 684–692.Google Scholar