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The Catharanthus Roseus (Vinca Rosea) Alkaloids: A New Glass of Stathmokinetic Agents

Published online by Cambridge University Press:  01 August 2014

G. Cardinali ,
G. Cardinali  and
G. Centurelli
G. Cardinali
Affiliation:
Istituto di Genetica Medica dell'Università di Roma
G. Cardinali
Affiliation:
Istituto di Genetica Medica dell'Università di Roma
G. Centurelli
Affiliation:
Istituto di Genetica Medica dell'Università di Roma

Summary

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Vinblastine (VLB) and vincristine (VCR) are two alkaloids (extracted from the plant Catahranthus roseus) which possess a definite antitumor activity. The antitumor activity. The antimitotic action of these two alkaloids was studied both on normal bone marrow and leukemic cells. Comparative studies showed that they are, like colchicine, spindle poisons. They, however, differ from colchicine and its derivatives in some of their biological activities.

The problem of the relationship between antitumor and antimitotic activity of VLB and VCR is discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 197 - 208
Copyright
Copyright © The International Society for Twin Studies 1968

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