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An Unusual Case of Hemoglobin Bart's Hydrops Fetalis

Published online by Cambridge University Press:  01 August 2014

I. Halbrecht  and
F. Shabtai
I. Halbrecht*
Affiliation:
Research Institute of Human Reproduction and Fetal Development, Tel Aviv University Medical School, and Hasharon Hospital, Petah Tikva, Israel
F. Shabtai
Affiliation:
Research Institute of Human Reproduction and Fetal Development, Tel Aviv University Medical School, and Hasharon Hospital, Petah Tikva, Israel
*
Hasharon Hospital, Petah Tikva, Israel

Abstract

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A baby with alpha-chain thalassemia hydrops fetalis was born to an Iraqian Jewish couple of Iraqi-Kurdish extraction. Hemoglobin Bart's constituted only 40% of the total hemoglobin, much less than usually found in alpha-thalassemia hydrops fetalis.

That this is a particular expression of hemoglobin H disease is considered. The likelihood of two alpha-chain loci, rather than one alpha-chain locus, in this family, is also discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 97 - 103
Copyright
Copyright © The International Society for Twin Studies 1975

References

REFERENCES

Abramson, R.K., Rucknagel, D.L., Shreffler, D.C. 1969. Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians. Science, 169: 194.CrossRefGoogle Scholar
Banwell, G.S., Strickland, M. 1964. Haemoglobinopathy associated with recurrent stillbirth. J. Obstet. Gynecol. Br. Commonw., 71: 788.CrossRefGoogle ScholarPubMed
Brimhall, B., Hollán, S., Jones, R.T., Koler, R.D., Stocklen, Z., Szeleny, J.G. 1970. Multiple alphachain loci human hemoglobin. Clin. Res., 18:184.Google Scholar
Diamond, M.P., Cotgrove, J., Parker, A. 1965. Case of intrauterine death due to alpha-thalassaemia. Br. Med. J., 2: 278.CrossRefGoogle ScholarPubMed
Driscoll, S.G. 1966. Hydrops fetalis. N. Engl. J. Med., 275: 1432.CrossRefGoogle ScholarPubMed
Halbrecht, I., Ben-Porat, S. 1967. The incidence of Bart's hemoglobin in the cord blood of 3218 newborns of different ethnic groups in Israel (in Hebrew). Harefuah, 73: 223.Google Scholar
Kan, Y.W., Allen, A., Lowenstein, L. 1967. Hydrops fetalis with alpha-thalassaemia. N. Engl. J. Med., 276: 18.CrossRefGoogle Scholar
Kattamis, C., Lehmann, H. 1970. Duplication of alpha thalassaemia gene in three families with Hb H disease. Lancet, 2: 635.CrossRefGoogle Scholar
Lehmann, H. 1970. Different types of alpha-thalassaemia and significance of Hb Bart's in neonates. Lancet, 2, 78.CrossRefGoogle Scholar
Lie-Injo, L.E., Hie, Jo Bwuan. 1960. Hydrops fetalis with fast moving hemoglobin. Br. Med. J., 2: 1649.Google Scholar
Lie-Injo, L. E., Gie, Lie Hong. 1961. Abnormal hemoglobin production as probable cause of erythroblastosis and hydrops fetalis in uniovular twins. Acta Haematol., 25: 192.Google ScholarPubMed
Lie-Injo, L. E. 1962. Alpha thalassaemia and hydrops fetalis in Malaya: report of five cases. Blood, 20: 581.Google ScholarPubMed
Lie-Injo, L.E., Gie, Lie Hong, Ager, J.A.M., Lehmann, H. 1962. Alpha thalassaemia as a cause of hydrops fetalis. Br. J. Haematol., 8: 1.Google Scholar
Na Nakorn, S., Wasi, P., Pornpatkul, M., Pootrakul, S.N. 1969. Further evidence for a genetic basis of Hb H disease from newborn offspring of patients. Nature (Lond.), 223: 59.CrossRefGoogle Scholar
Pearson, H.A., Shanklin, D.R., Brodine, C.R. 1965. Alpha-thalassaemia as a cause of non-immunological hydrops. Am. J. Dis. Child., 109: 168.Google Scholar
Sjölin, S., Wallenius, G., Wranne, L. 1964. Hemoglobin Bart's and H in Swedish boy. Acta Haematol., 32: 239.CrossRefGoogle Scholar
Zaizov, R., Matoth, Y. 1972. Isr. J. Med. Sci., 8: 11.Google Scholar