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Development of L-Line X-Ray Fluorescence Instrumentation and its Applications to In-Vivo Measurement of Lead in Bone

Published online by Cambridge University Press:  06 March 2019

John E. Rosen
John E. Rosen*
Affiliation:
Albert Einstein College of Medicine, Montefiore Medical Center Bronx, New York 10467
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Extract

Initially, Wielopolski (Wielopolski et al. 1981) used x-rays from either a 125I or a 105Cd source to estimate lead (Pb) in tibial cortical bone in intact legs, post-mortem. This system utilized the Lα and Lβ x-rays of Pb with energies of 10.5 and 12.6 keV, respectively. The minimum detection limit (MDL) was considered to be comparable with existing K-line x-ray fluorescence (KXRF) instruments, namely, 20-30 ppm. The feasibility of partially polarized radiation (Barkla, 1906) was assessed from a 125I source on Pb (No3)2 (10,000 ppm) dissolved in wa:er. Reduction of the detector total count rate was observed by a factor of two; and reduction in background by the same factor was appaent. This preliminary study suggested that, with improved design, tlie MDL might be lowered by a factor of five (Wielopolski et al., 1981).

Type
VIII. In Vivo Applications of XRS
Information
Advances in X-Ray Analysis , Volume 38: Forty-third Annual Conference on Applications of X-ray Analysis , 1994 , pp. 573 - 577
Copyright
Copyright © International Centre for Diffraction Data 1994

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References

Barkla, C. G. Polarization in secondary Roentgen radiation. Proc Roy Soc London Ser A 1906; 77: 247–255.Google Scholar
Greenberg, A., Parkinson, D. K., Fetterolf, D. E, Puschett, J. B, Ellis, K. J, Wielopolski, L, Vaswani, A. N, Cohn, S. H, Landrigan, P. J. Effects of elevated lead and cadmium burdens on renal function and calcium metabolism. Arch Environmental Heath 1986; 41: 69–7.Google Scholar
International Commission on Radiological Protection. Recommendations of the International Commission on Radiological Protection. Publication 60, Oxford, Pergamon Press 1991. 4-9Google Scholar
Kalef-Ezra, J. A, Slatkin, D. N, Rosen, J. R, Wielopolski, L. Radiation risk to the human conceptus attributable to measurement of maternal tibial bone lead by L-line x-ray fluorescence. Health Phys 1990; 58: 217–21.Google Scholar
Markowitz, M. E, Bijur, P. E, Ruff H, Rosen, J. F. Effects of calcium disodium versenate chelation in moderate childhood lead poisoning. Pediatrics 1993; 92: 265–27.Google Scholar
National Academy of Sciences (NAS). Measuring Lead Exposure in Infants, Children and Other Sensitive Populations. National Academy of Sciences, National Research Council. National Academy Press, Washington DC, 1993Google Scholar
Rosen, J. F, Markowitz, M. E, Bijur, P. E, Jenks, S. T, Wielopolski, L, Kalef-Ezra, J. A, Slatkin, D. N. L-x-ray fluorescence of cortical bone lead compared with the CaNa2EDTA test in lead-toxic children: Public health implications. Proc Nat Acad Sci (USA) 1989; 65: 685–689, 759 Google Scholar
Rosen, J. F, Markowitz, M. E, Bijur, P. E, Wielopolski, L, Slatkin, D. N. Sequential measurements of bone lead by L-x-ray fluorescence in CaNa2EDTA-treated lead-toxic children. Environ Health Perspectives 1991; 92: 271–27.Google Scholar
Rosen, J. E Health effects of lead at low exposure levels: Expert consensus and rationale for lowering the definition of childhood lead poisoning. Amer J Dis Child 1992;146:1278–1281 Google Scholar
Rosen, J. F, Markowitz, M. E. Trends in the management of childhood lead poisoning. Neurotoxicot 1991; 14: 211–21.Google Scholar
Rosen, J. F, Crocetti, A. M, Balbi, K, et at Bone lead content assessed by L-line x-ray fluorescence in lead-exposed and non-lead-exposed suburban populations in the United States. Proc Nat Acad Sci (USA) 1993; 90: 2789–279.Google Scholar
Slatkin, D. N, Kalef-Ezra, I. A, Balbi, K, Rosen, J. F, Wielopolski, L, Radiation risk of L-line x-ray fluorescence measurements of tibial bone lead: Radio epidemiologic considerations. Radial Prot Dosimetry 1991; 37: 111–116.Google Scholar
Slatkin, D. N, Kalef-Ezra, J. A, Balbi, K. E, Wielopolski L, Rosen, J. F. L-line x-ray fluorescence of tibial lead: Correction and adjustment of radiation risk to ICRP 60. Radiat Prot Dosimetry 1992; 43: 319–32.Google Scholar
Wielopolski, L. Slatkin, D. N, Vartsky D, Ellis, K. J, Cohn, S. H. Feasibility study for the in vivo measurement of lead in bone using L-X-Ray fluorescence. IEEE Trans Nuclear Science 1981; NS-28:114–116 Google Scholar
Wielopolski, L. Rosen, J. F, Slatkin, D. N, Vartsky, D, Ellis, K. J, Cohn, S. H. Feasibility of noninvasive analysis of lead in the human tibia by soft x-ray fluorescence. Med Phys 1983; 10: 248–25.Google Scholar
Wielopolski, L. Ellis, K. J, Vaswani, A. N, Cohn, S. H, Greenberg, A. Puschett, J. B, Parkinson, D. K, Fetterolf, D. E, Landrigan, P. J. In vivo bone lead measurements: A rapid monitoring method for cumulative lead exposure. Am J Indust Med 1986; 9: 221–22.Google Scholar
Wielopolski, L. Slatkin, D. N, Kalef-Ezra, J. A, Rosen, J. E Non-invasive detection of tibial bone lead in intact legs by L x-ray fluorescence. The Toxicologic. 1987. Abstract, pp 77 Google Scholar
Wielopolski, L. Rosen, J. F, Slatkin, D. N, Zhang, R, Kalef-Ezra, J. A, Rothman, J. C, Maryanski, M, Jenks, S. T In vivo measurement of cortical bone using polarized radiation. Med Phys 1989; 16: 521–522.Google Scholar