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Antiglucocorticoids in psychiatry

  • Sean A. McIsaac, Åsa Westrin and Allan H. Young


Significant evidence has accrued suggesting that the hypothalamic–pituitary–adrenal (HPA) axis plays a role in some psychiatric disorders. This article reviews the physiology of the HPA axis, evidence of dysfunction in this axis in psychiatric illnesses and the role that this dysfunction might play in pharmacological treatment resistance. Future therapeutic strategies that may potentially arise from these researches are briefly outlined.

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Corresponding author

Professor Allan Young, Institute of Mental Health, University of British Columbia, 5950 University Blvd, Vancouver, BC, V6T 2A1, Canada. Email:


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For a commentary on this article see pp. 250–252, this issue.

Declaration of Interest

A.Y. holds related grants from the Stanley Medical Research Institute and the Medical Research Council (UK) and has filed a provisional patent concerning the use of antiglucocorticoids as an adjunctive to antidepressant therapies.



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Antiglucocorticoids in psychiatry

  • Sean A. McIsaac, Åsa Westrin and Allan H. Young


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Antiglucocorticoids in psychiatry

  • Sean A. McIsaac, Åsa Westrin and Allan H. Young
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