Hostname: page-component-848d4c4894-2xdlg Total loading time: 0 Render date: 2024-06-19T00:32:43.308Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of d-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients

Published online by Cambridge University Press:  29 January 2020

Masachika Niimi Open the ORCID record for Masachika Niimi [Opens in a new window] ,
Yuko Fujita ,
Tamaki Ishima ,
Kenji Hashimoto ,
Nobuyuki Sasaki ,
Takatoshi Hara ,
Naoki Yamada  and
Masahiro Abo
Masachika Niimi*
Affiliation:
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan Department of Rehabilitation Medicine, Tokyo General Hospital, Tokyo, Japan
Yuko Fujita
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Tamaki Ishima
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Kenji Hashimoto
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Nobuyuki Sasaki
Affiliation:
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
Takatoshi Hara
Affiliation:
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
Naoki Yamada
Affiliation:
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
Masahiro Abo
Affiliation:
Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
*
Author for correspondence: Masachika Niimi, Email: pomardon2010@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Abnormalities in neurotransmission via N-methyl-d-aspartic acid receptor (NMDAR) play a role in the pathophysiology of neuropsychiatric disorders. The impact of repetitive transcranial magnetic stimulation (rTMS) on NMDAR-related amino acids remains unknown. We aim to investigate the effects of rTMS on NMDAR-related amino acids in serum of post-stroke patients.

Methods:

Ninety-five consecutive post-stroke patients with upper limb hemiparesis were recruited. In 27 patients, the Beck Depression Inventory (BDI) score was 10 or higher. Twelve depressed patients underwent rehabilitation in combination with rTMS and 15 non-depressed patients underwent rehabilitation only without rTMS for 14 days. 1 Hz rTMS was applied to the primary motor area in the non-lesional hemisphere. BDI was conducted before and after treatment. Serum glutamine, glutamate, glycine, l-serine, and d-serine levels were measured before and after treatment.

Results:

There were no differences between depressed patients and non-depressed patients in clinical characteristics, levels of the five amino acids in serum, and the ratio of amino acids. However, in 27 depressed patients, there was a significant correlation between levels of glutamate in serum and BDI (ρ = 0.428, p = 0.026). BDI decreased significantly in depressed patients after treatment with or without rTMS. d-serine decreased in the rehabilitation with rTMS group, but increased in the rehabilitation without rTMS group. l-serine increased in the rehabilitation with rTMS group, but decreased in the rehabilitation without rTMS group.

Conclusion:

The results suggest that rTMS can modulate NMDAR-related amino acids in blood, producing beneficial effects.

Keywords

N-methyl-D-aspartic acid receptorbrain-derived neurotrophic factorneural plasticitytranscranial magnetic stimulationglutamatergic neurotransmission
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 32 , Issue 3 , June 2020 , pp. 128 - 134
Copyright
© Scandinavian College of Neuropsychopharmacology 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beck, AT, Ward, CH, Mendelson, M, Mock, JE and Erbaugh, JK (1961) An inventory for measuring depression. Archives of General Psychiatry 4(6), 561–571.CrossRefGoogle ScholarPubMed
Burvill, PW, Johnson, GA, Jamrozik, KD, Anderson, CS, Stewart-Wynne, EG and Chakera, TM (1995) Prevalence of depression after stroke: the perth community stroke study. The British Journal of Psychiatry 166(3), 320–327.CrossRefGoogle ScholarPubMed
Croarkin, PE, Nakonezny, PA, Wall, CA, Murphy, LL, Sampson, SM, Frye, MA and Port, JD (2016) Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents. Psychiatry Research: Neuroimaging 247(January), 25–33.CrossRefGoogle ScholarPubMed
Duan, X, Yao, G, Liu, Z, Cui, R and Yang, W (2018) Mechanisms of Transcranial Magnetic Stimulation Treating on Post-stroke Depression. Frontiers in Human Neuroscience 12(May), 1–6.CrossRefGoogle ScholarPubMed
Ellis, C, Grubaugh, AL and Egede, L (2013) Factors associated with SF-12 physical and mental health quality of life scores in adults with stroke. Journal of Stroke and Cerebrovascular Diseases 22(4), 309–317.CrossRefGoogle ScholarPubMed
Folstein, MF, Folstein, SE and McHugh, PR (1975) “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12(3), 189–198.CrossRefGoogle ScholarPubMed
Hashimoto, K, Sawa, A and Iyo, M (2007) Increased levels of glutamate in brains from patients with mood disorders. Biological Psychiatry 62(11), 1310–1316.CrossRefGoogle ScholarPubMed
Hashimoto, K, Yoshida, T, Ishikawa, M, Fujita, Y, Niitsu, T, Nakazato, M, Watanabe, H, Sasaki, T, Shiina, A, Hashimoto, T, Kanahara, N, Hasegawa, T, Enohara, M, Kimura, A and Iyo, M (2016) Increased serum levels of serine enantiomers in patients with depression. Acta Neuropsychiatrica 28(3), 173–178.CrossRefGoogle ScholarPubMed
Keck, ME, Sillaber, I, Ebner, K, Welt, T, Toschi, N, Kaehler, ST, Singewald, N, Philippu, A, Elbel, GK, Wotjak, CT, Holsboer, F, Landgraf, R and Engelmann, M (2000) Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. European Journal of Neuroscience 12(10), 3713–3720.CrossRefGoogle ScholarPubMed
Lefaucheur, JP, André-Obadia, N, Antal, A, Ayache, SS, Baeken, C, Benninger, DH, Cantello, RM, Cincotta, M, de Carvalho, M, De Ridder, D, Devanne, H, Di Lazzaro, V, Filipović, SR, Hummel, FC, Jääskeläinen, SK, Kimiskidis, VK, Koch, G, Langguth, B, Nyffeler, T, Oliviero, A, Padberg, F, Poulet, E, Rossi, S, Rossini, PM, Rothwell, JC, Schönfeldt-Lecuona, C, Siebner, HR, Slotema, CW, Stagg, CJ, Valls-Sole, J, Ziemann, U, Paulus, W and Garcia-Larrea, L (2014). Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology 125(11), 2150–2206.CrossRefGoogle Scholar
Madeira, C, Lourenco, MV, Vargas-Lopes, C, Suemoto, CK, Brandão, CO, Reis, T, Leite, RE, Laks, J, Jacob-Filho, W, Pasqualucci, CA, Grinberg, LT, Ferreira, ST and Panizzutti, R (2015). d-serine levels in Alzheimer’s disease: implications for novel biomarker development. Translational Psychiatry 5(May), e561.CrossRefGoogle ScholarPubMed
Mauri, MC, Ferrara, A, Boscati, L, Bravin, S, Zamberlan, F, Alecci, M and Invernizzi, G (1998) Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment. Neuropsychobiology 37(3), 124–129.CrossRefGoogle ScholarPubMed
Mitani, H, Shirayama, Y, Yamada, T, Maeda, K, Ashby, CR Jr and Kawahara, R (2006) Correlation between plasma levels of glutamate, alanine and serine with severity of depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 30(6), 1155–1158.CrossRefGoogle ScholarPubMed
Niimi, M, Hashimoto, K, Kakuda, W, Miyano, S, Momosaki, R, Ishima, T and Abo, M (2016) Role of brain-derived neurotrophic factor in beneficial effects of repetitive transcranial magnetic stimulation for upper limb hemiparesis after stroke. PLoS One 11(3), e0152241.CrossRefGoogle ScholarPubMed
Niimi, M, Sasaki, N, Kimura, C, Hara, T, Yamada, N and Abo, M (2019) Sleep during low-frequency repetitive transcranial magnetic stimulation is associated with functional improvement in upper limb hemiparesis after stroke. Acta Neurologica Belgica 119(2), 233–238.CrossRefGoogle ScholarPubMed
Schuch, FB, Vancampfort, D, Richards, J, Rosenbaum, S, Ward, PB and Stubbs, B (2016) Exercise as a treatment for depression: a meta-analysis adjusting for publication bias. Journal of Psychiatric Research 77(June), 42–51.CrossRefGoogle ScholarPubMed
Seewoo, BJ, Feindel, KW, Etherington, SJ and Rodger, J (2019) Frequency-specific effects of low-intensity rTMS can persist for up to 2 weeks post-stimulation: A longitudinal rs-fMRI/MRS study in rats. Brain Stimulation 12(6), 1526–1536.CrossRefGoogle ScholarPubMed
Slotema, CW, Blom, JD, Hoek, HW and Sommer, IE (2010) Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. The Journal of Clinical Psychiatry 71(7), 873–884.CrossRefGoogle ScholarPubMed
Villardita, C (1985) Progressive matrices and intellectual impairment in patients with focal brain damage. Cortex 21(4), 627–634.CrossRefGoogle ScholarPubMed
Yang, XR, Kirton, A, Wilkes, TC, Pradhan, S, Liu, I, Jaworska, N, Damji, O, Keess, J, Langevin, LM, Rajapakse, T, Lebel, RM, Sembo, M, Fife, M and MacMaster, FP (2014) Glutamate alterations associated with transcranial magnetic stimulation in youth depression: a case series. The Journal of ECT 30(3), 242–247.CrossRefGoogle ScholarPubMed
Zhang, N, Xing, M, Wang, Y, Tao, H and Cheng, Y (2015) Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia. Neuroscience 311, 284–291.CrossRefGoogle Scholar