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Intrinsic functional connectivity, CSF biomarker profiles and their relation to cognitive function in mild cognitive impairment

Published online by Cambridge University Press:  05 December 2019

Silke Matura Open the ORCID record for Silke Matura [Opens in a new window] ,
Jan Köhler ,
Andreas Reif ,
Fabian Fusser ,
Tarik Karakaya ,
Monika Scheibe ,
Felix Ehret ,
Daniel Hartmann ,
Jun-Suk Kang  and
Christoph Mayer
...Show all authors
Silke Matura*
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Jan Köhler
Affiliation:
Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Andreas Reif
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Fabian Fusser
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Tarik Karakaya
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Monika Scheibe
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Felix Ehret
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Daniel Hartmann
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Jun-Suk Kang
Affiliation:
Department of Neurology, University Hospital, Goethe University, Frankfurt, Germany
Christoph Mayer
Affiliation:
Department of Neurology, University Hospital, Goethe University, Frankfurt, Germany
David Prvulovic
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany
Johannes Pantel
Affiliation:
Institute of General Practice, Goethe University, Frankfurt, Germany
*
Author for correspondence: Silke Matura, Email: Silke.Matura@kgu.de
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Abstract

Mild cognitive impairment (MCI) often precedes Alzheimer’s Dementia (AD), and in a high proportion of individuals affected by MCI, there are already neuropathological processes ongoing that become more evident when patients progress to AD. Accordingly, there is a need for reliable biomarkers to distinguish between normal aging and incipient AD. Recent research suggests that, in addition to established biomarkers such as CSF Aß42, total tau and hyperphosphorylated tau, resting state connectivity established by functional magnetic resonance imaging might also be a feasible biomarker for prodromal stages of AD. In order to explore this possibility, we investigated resting state functional connectivity as well as cerebrospinal fluid (CSF) biomarker profiles in patients with MCI (n = 30; age 66.43 ± 7.06 years) and cognitively healthy controls (n = 38; age 66.89 ± 7.12 years). CSF Aß42, total tau and hyperphosphorylated tau concentrations were correlated with measures of cognitive performance (immediate and delayed recall, global cognition, processing speed). Moreover, MCI-related alterations in intrinsic functional connectivity within the default mode network were investigated using functional resting state MRI. As expected, MCI patients showed decreased CSF Aß42 and increased total tau concentrations. These alterations were associated with cognitive performance. However, there were no differences between MCI patients and cognitively healthy controls regarding intrinsic functional connectivity. In conclusion, our results indicate that CSF protein profiles seem to be more closely related to cognitive decline than alterations in resting state activity. Thus, resting state connectivity might not be a reliable biomarker for early stages of AD.

Keywords

magnetic resonance imagingcognitionamyloidresting state fMRI
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 32 , Issue 4 , August 2020 , pp. 206 - 213
Copyright
© Scandinavian College of Neuropsychopharmacology 2019

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