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Event-related potentials and white matter lesions in bipolar disorder

  • E. F. P. M. Vuurman (a1), A. Honig (a2), T. H. Lamers (a2), J. Wiersma (a1), L. Krabbendam (a1), P. A. M. Hofman (a3), W. A. Nolen (a4) and J. Jolles (a1)...



To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.


Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory ‘oddball’ task, and the amplitude of the resulting P300 wave was compared.


Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.


Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.


Corresponding author

EFPM Vuurman, Institute of Brain and Behavior, University of Maastricht, Postbus 616, 6200 MD Maastricht, the Netherlands. Tel: +31 433881046; Fax: +31 433884092; E-mail:


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Event-related potentials and white matter lesions in bipolar disorder

  • E. F. P. M. Vuurman (a1), A. Honig (a2), T. H. Lamers (a2), J. Wiersma (a1), L. Krabbendam (a1), P. A. M. Hofman (a3), W. A. Nolen (a4) and J. Jolles (a1)...


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