Skip to main content Accessibility help
×
Home

Differential BOLD responses to auditory target stimuli associated with a skin conductance response

  • Jim Lagopoulos (a1) (a2) (a3), Evian Gordon (a4) (a5) and Philip B. Ward (a1) (a3)

Abstract

Background:

The orienting reflex (OR) is a fundamental biological mechanism thought to reflect automatic adaptive processing of environmental stimuli necessary for successful interaction with the environment. It has been hypothesized that the OR is generated in response to novelty such as in the case where a mismatch results between an internal neuronal template stored in working memory and incoming stimuli. Recent blood oxygenated level dependant (BOLD) activation studies that have investigated networks involved in the processing of novelty have suggested the recruitment of a distributed limbic-neocortical network. In the present study, event-related functional resonance imaging with simultaneous autonomic electrodermal activity was used to detect single trials of an auditory oddball task associated with the OR.

Results:

The pattern of activations indicated two distinct, but partially overlapping, networks. Predominantly, frontal activations were seen for the target stimuli that did elicit an OR, including the orbitofrontal gyrus and anterior cingulate gyrus, as well as activations in the anterior thalamus and cerebellum. On contrary, parietal activations including the supramarginal gyrus and precuneus were seen for the target stimuli that that did not elicit an OR.

Copyright

Corresponding author

Dr Jim Lagopoulos, Mayne Clinical Research Imaging Centre, Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia. Tel: +61 2 93822998; Fax: +61 2 93828208; E-mail: jim.lagopoulos@unsw.edu.au

References

Hide All
1.Pavlov, IP.Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex. Oxford: Oxford University and Press Humphrey Milford, 1927.
2.Sokolov, EN.Perception and the conditioned reflex. New York: Pergamon, 1963.
3.Sokolov, EN.The neuronal mechanisms of the orienting reflex. New Jersey: Hillsdale, 1975.
4.Williams, LM, Brammer, MJ, Skerrett, Det al. The neural correlates of orienting: an integration of fMRI and skin conductance orienting. Neuroreport 2000;11: 30113015.
5.Williams, LM, Phillips, ML, Brammer, MJet al. Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage 2001;14: 10701079.
6.Bahramali, H, Gordon, E, Lim, CLet al. Evoked related potentials associated with and without an orienting reflex. Neuroreport 1997;8: 26652669.
7.Lagopoulos, J, Gordon, E, Barhamali, Het al. Dysfunctions of automatic (P300a) and controlled (P300b) processing in Parkinson's disease. Neurol Res 1998;20: 510.
8.Squires, NK, Squires, KC, Hillyard, SA.Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 1975;38: 387401.
9.Shiffrin, RM, Schneider, W.Controlled and automatic human information processing: II. Psychol Rev 1977;84: 127190.
10.Schneider, W, Shiffrin, RM.Controlled and automatic human information processing: I. detection, search and attention. Psychol Rev 1977;84: 166.
11.Hillyard, SA, Courchesne, E, Krausz, HI, Picton, TW. (1976) Scalp topography of the P3 wave in different auditory tasks. In: McCallum, WC, ed. Responsive brain: proceedings of the Third International Congress on event-related slow potentials of the brain, pp. 4968. Bristol: John Wright and Sons Ltd.
12.Snyder, E, Hillyard, SA.Long-latency evoked potentials to irrelevant, deviant stimuli. Behav Biol 1976;16: 319331.
13.Polich, J, Howard, L, Starr, A.Effects of age on the P300 component of the event-related potential from auditory stimuli: peak definition, variation and measurement. J Gerontol 1985;40: 721726.
14.Knight, RT.Aging decreases auditory event-related potentials to unexpected stimuli in humans. Psychol Aging 1987;8: 109113.
15.Tachibana, H, Toda, K, Sugita, M.Actively and passively evoked P3 latency of event-related potentials in Parkinson's Disease. J Neurol Sci 1992;111: 134142.
16.Schroger, E, Giard, MH, Wolff, C.Auditory distraction: event-related potential and behavioral indices. Clin Neurophysiol 2000;111: 14501460.
17.Knight, RT.Contribution of human hippocampal region to novelty detection. Nature 1996;383: 256259.
18.Knight, RT, Hillyard, SA, Woods, DL, Neville, HJ.The effects of frontal cortex lesions on event-related potentials during auditory selective attention. Electroencephalogr Clin Neurophysiol 1981;52: 571582.
19.Lyytinen, H, Blomberg, AP, Naatanen, R.Event-related potentials and autonomic responses to a change in unattended auditory stimuli. Psychophysiology 1992;29: 523534.
20.Boucsein, W.Electrodermal activity. New York: Plenum Press, 1992.
21.Lagopoulos, J, Malhi, GS, Shnier, RS.A system for recording artifact-free skin conductance responses in the MRI scanner. Behavioral research methods, instruments and computers 2005;37 (4): 657664.
22.Barry, RJ, Sokolov, EN.Habituation of phasic and tonic components of the orienting reflex. Int J Psychophysiol 1993;15: 3042.
23.Talaraich, J, Tournoux, P.Co-planar stereotactic atlas of the human brain. Stuttgart: Thieme, 1988.
24.Woods, RP, Cherry, SR, Mazziotta, JC.Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 1992;16: 620633.
25.Bosch, V.Statistical analysis of multi-subject fMRI data: assessment of focal activations. J Magn Reson Imaging 2000;11: 6164.
26.Menon, V, Ford, JM, Lim, KO, Glover, GH, Pfefferbaum, A.Combined event-related fMRI and EEG evidence for temporal-parietal cortex activation during target detection. Neuroreport 1997;8: 30293037.
27.Yoshiura, T, Zhong, J, Shibata, DK, Kwok, WE, Shrier, DA, Numaguchi, Y.Functional MRI study of auditory and visual oddball tasks. Neuroreport 1999;10: 16831688.
28.Linden, DE, Prvulovic, D, Formisano, Eet al. The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. Cereb Cortex 1999;9: 815823.
29.McCarthy, G, Luby, M, Gore, J, Goldman, R.Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. J Neurophysiol 1997;77: 16301634.
30.Opitz, B, Mecklinger, A, Friederici, AD, Von Cramon, DY.The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. Cereb Cortex 1999a;9: 379391.
31.Devinsky, O, Morrell, MJ, Vogt, BA.Contributions of anterior cingulate cortex to behaviour. Brain 1995;118 (Pt. 1):279306.
32.Knight, RT, Scabini, D, Woods, DL, Clayworth, CC.Contributions of temporal-parietal junction to the human auditory P3. Brain Res 1989;502: 109116.
33.Kiehl, KA, Laurens, KR, Duty, TL, Forster, BB, Liddle, PF.Neural sources involved in auditory target detection and novelty processing: an event-related fMRI study. Psychophysiology 2001;38: 133142.
34.Opitz, B, Mecklinger, A, Von Cramon, DY, Kruggel, F.Combining electrophysiological and hemodynamic measures of the auditory oddball. Psychophysiology 1999b;36: 142147.
35.Clark, VP, Fannon, S, Lai, S, Benson, R, Bauer, L.Responses to rare visual target and distractor stimuli using event-related fMRI. J Neurophysiol 2000;83: 31333139.
36.Downar, J, Crawley, AP, Mikulis, DJ, Davis, KD.A multimodal cortical network for the detection of changes in the sensory environment. Nat Neurosci 2000;3: 277283.
37.Risold, PY, Swanson, LW.Structural evidence for functional domains in the rat hippocampus. Science 1996;272: 14841486.
38.Damasio, AR.Descartes' error. New York: Putnam, 1994.
39.Rolls, ET.The brain and emotion. Oxford: Oxford University Press, 1999.
40.Iversen, SD, Mishkin, M.Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity. Exp Brain Res 1970;11: 376386.
41.Jones, B, Mishkin, M.Limbic lesions and the problem of stimulus – reinforcement associations. Exp Neurol 1972;36: 362377.
42.Rolls, ET, Hornak, J, Wade, D, McGrath, J.Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J Neurol Neurosurg Psychiatry 1994;57: 15181524.
43.O'Doherty, J, Rolls, ET, Francis, Set al. Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex. Neuroreport 2000; 11: 893897.
44.Fabiani, M, Friedman, D.Changes in brain activity patterns in aging: the novelty oddball. Psychophysiology 1995;32: 579594.
45.Goldman-Rakic, PS.Working memory and the mind. Sci Am 1992;267: 110117.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed