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Correlation of reduced social communicational and interactional skills with regional grey matter volumes in schizophrenia patients

Published online by Cambridge University Press:  10 April 2017

Miho Ota ,
Junko Matsuo ,
Noriko Sato ,
Toshiya Teraishi ,
Hiroaki Hori ,
Kotaro Hattori ,
Yoko Kamio  and
Hiroshi Kunugi
Miho Ota*
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Junko Matsuo
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Noriko Sato
Affiliation:
Department of Radiology, National Center of Neurology and Psychiatry, Ogawa-Higashi, Kodaira, Tokyo, Japan
Toshiya Teraishi
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Hiroaki Hori
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Kotaro Hattori
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Yoko Kamio
Affiliation:
Department of Child and Adolescent Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Hiroshi Kunugi
Affiliation:
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
*
Dr. Miho Ota, Department of Mental Disorder Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. Tel: +81 42 341 2712; Fax: +81 42 346 2094; E-mail: ota@ncnp.go.jp
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Abstract

Objective

Recent studies have detected similarities between autism spectrum disorder and schizophrenia. We investigated structural abnormalities associated with autistic-like traits in patients with schizophrenia by voxel-based morphometry.

Methods

Patients with schizophrenia and healthy subjects were evaluated by the adult version of the social responsiveness scale (SRS-A), which is sensitive to autistic traits and symptoms even under subthreshold conditions, and magnetic resonance imaging.

Results

There were significant decreases in the anterior cingulate cortex, bilateral hippocampi, cerebellums, and right insula of patients with schizophrenia, compared with healthy subjects. We found significant negative correlations of the social communication and interaction (SCI) score, a subscale of SRS-A, with grey matter volume in the left posterior superior temporal region of schizophrenia patients. When subscales of SCI were examined separately in schizophrenic patients, negative correlations were observed between the social cognition score and the volumes of the left posterior superior temporal region, and between social motivation and the posterior cingulate cortex.

Conclusion

We found significant negative correlation between the SCI score and the grey matter volume in the left posterior superior temporal region of schizophrenia patients. This area was the region affected in previous studies of autistic spectrum disorders. Further, this area was associated with the theory of mind. Schizophrenia patients not necessarily show the impairment of SCI, nor this correlated region was not always the point with schizophrenia-specific change. However, we reveal the relationship between the left posterior superior temporal gyrus and the severity of the SCI in schizophrenia by using with SRS-A.

Keywords

autistic behaviourmagnetic resonance imagingschizophreniasocial responsiveness scale for adultsvolumetry
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 29 , Issue 6 , December 2017 , pp. 374 - 381
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Copyright
© Scandinavian College of Neuropsychopharmacology 2017 

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