Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-24T11:37:14.358Z Has data issue: false hasContentIssue false

Brain-derived neurotrophic factor: a modifiable common mediator in both the pathophysiology of psychiatric illness and in successful pharmacological treatments

Published online by Cambridge University Press:  24 June 2014

Felice N. Jacka
Affiliation:
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, VIC, Australia
Clarissa S. Gama
Affiliation:
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, VIC, Australia Laboratório de Psiquiatria Molecular, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil Programa de Pós-Graduação em Medicina: Psiquiatria, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil Schizophrenia Program, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
Michael Berk
Affiliation:
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, VIC, Australia Orygen Research Center, Parkville, VIC, Australia Mental Health Research Institute, Parkville, VIC, Australia

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Intervention Insights
Copyright
Copyright © 2008 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Huang, EJ, Reichardt, LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001;24:677736. CrossRefGoogle ScholarPubMed
Hashimoto, K, Shimizu, E, Iyo, M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 2004;45:104114. CrossRefGoogle ScholarPubMed
Vaynman, S, Gomez-Pinilla, F. Revenge of the “sit”: how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J Neurosci Res 2006;84:699715. CrossRefGoogle Scholar
Malcangio, M, Lessmann, V. A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors. Trends Pharmacol Sci 2003;24:116121. CrossRefGoogle ScholarPubMed
Smith, MA, Makino, S, Kvetnansky, R, Post, RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995;15(Pt 1):17681777. Google ScholarPubMed
Shimizu, E, Hashimoto, K, Okamura, Net al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:7075. CrossRefGoogle ScholarPubMed
Palomino, A, Vallejo-illarramendi, A, Gonzalez-pinto, Aet al. Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients. Schizophr Res 2006;86:321322. CrossRefGoogle ScholarPubMed
Cunha, AB, Frey, BN, Andreazza, ACet al. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci Lett 2006;398:215219. CrossRefGoogle ScholarPubMed
Tan, YL, Zhou, DF, Cao, LY, Zou, YZ, Zhang, XY. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neurosci Lett 2005;382:2732. CrossRefGoogle ScholarPubMed
Neves-Pereira, M, Mundo, E, Muglia, P, King, N, Macciardi, F, Kennedy, JL. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 2002;71:651655. CrossRefGoogle Scholar
Rybakowski, JK, Borkowska, A, Czerski, PM, Skibinska, M, Hauser, J. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 2003;5:468472. CrossRefGoogle Scholar
Rybakowski, JK, Borkowska, A, Skibinska, Met al. Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin Neurosci 2006;60:7076. CrossRefGoogle Scholar
Duman, RS. Pathophysiology of depression: the concept of synaptic plasticity. Eur Psychiatry 2002;17(Suppl. 3):306310. CrossRefGoogle Scholar
Jacobs, BL, Praag, H, Gage, FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry 2000;5:262269. CrossRefGoogle Scholar
Strasser, A, Skalicky, M, Hansalik, M, Viidik, A. The impact of environment in comparison with moderate physical exercise and dietary restriction on BDNF in the cerebral parietotemporal cortex of aged Sprague-Dawley rats. Gerontology 2006;52:377381. CrossRefGoogle Scholar
Molteni, R, Barnard, RJ, Ying, Z, Roberts, CK, Gomez-pinilla, F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002;112:803814. CrossRefGoogle ScholarPubMed
Wu, A, Ying, Z, Gomez-pinilla, F. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 2004;19:16991707. CrossRefGoogle ScholarPubMed
Wu, A, Ying, Z, Gomez-pinilla, F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004;21:14571467. CrossRefGoogle ScholarPubMed
Lindqvist, A, Mohapel, P, Bouter, Bet al. High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol 2006;13:13851388. CrossRefGoogle Scholar
Delbosc, S, Paizanis, E, Magous, Ret al. Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis 2005;179:4349. CrossRefGoogle Scholar
Sohal, RS, Weindruch, R. Oxidative stress, caloric restriction, and aging. Science 1996;273:5963. CrossRefGoogle ScholarPubMed
Heilbronn, LK, De Jonge, L, Frisard, MIet al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006;295:15391548. CrossRefGoogle ScholarPubMed
Lebrun, B, Bariohay, B, Moyse, E, Jean, A. Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Auton Neurosci 2006;126–127:3038. CrossRefGoogle ScholarPubMed
Zhang, XY, Tan, YL, Zhou, DFet al. Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J Psychiatr Res 2007;41:9971004. CrossRefGoogle ScholarPubMed
Haddad, PM, Sharma, SG. Adverse effects of atypical antipsychotics: differential risk and clinical implications. CNS Drugs 2007;21:911936. CrossRefGoogle ScholarPubMed
Dishman, RK, Berthoud, HR, Booth, FWet al. Neurobiology of exercise. Obesity (Silver Spring) 2006;14:345356. CrossRefGoogle Scholar
van Praag, H, Christie, BR, Sejnowski, TJ, Gage, FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A 1999;96:1342713431. CrossRefGoogle ScholarPubMed
Uda, M, Ishido, M, Kami, K, Masuhara, M. Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult rat. Brain Res 2006;1104:6472. CrossRefGoogle ScholarPubMed
Vaynman, S, Ying, Z, Wu, A, Gomez-pinilla, F. Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity. Neuroscience 2006;139:12211234. CrossRefGoogle ScholarPubMed
Vaynman, S, Ying, Z, Gomez-pinilla, F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004;20:25802590. CrossRefGoogle ScholarPubMed
Gama, CS, Andreazza, AC, Kunz, M, Berk, M, Belmonte-de-Abreu, PS, Kapczinski, F. Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder. Neurosci Lett 2007;420:4548. CrossRefGoogle Scholar
Frey, BN, Andreazza, AC, Cereser, KMet al. Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sci 2006;79:281286. CrossRefGoogle Scholar
Park, SW, Lee, SK, Kim, JM, Yoon, JS, Kim, YH. Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats. Neurosci Lett 2006;402:2529. CrossRefGoogle Scholar
Bai, O, Chlan-fourney, J, Bowen, R, Keegan, D, Li, XM. Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J Neurosci Res 2003;71:127131. CrossRefGoogle ScholarPubMed
Nibuya, M, Nestler, EJ, Duman, RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 1996;16:23652372. Google Scholar
Duman, RS, Heninger, GR, Nestler, EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997;54:597606. CrossRefGoogle Scholar
Berk, M. Oxidative biology: new intervention opportunities in psychiatry. Acta Neuropsychiatr 2007;19:259260. CrossRefGoogle Scholar
Jacka, F, Berk, M. Food for thought. Acta Neuropsychiatr 2007;19:321323. CrossRefGoogle Scholar