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Biological theories of depressions: premisses - and progress?

Published online by Cambridge University Press:  18 September 2015

Extract

Although less undisputed in biological psychiatry than formerly, there are basically still two premisses which underly most hypotheses in biological depression research. These are deeply rooted in the medical way of thinking and have guided the construction of DSM-III. The first is that depressive symptoms and complaints cluster in one or more discrete syndromes, and the second is that these correspond to separate nosological entities, characterized by specific biological derangements and pathogenetic processes. Below a number of issues are raised which cast doubts on the validity of these premisses and on the progress made in pinpointing the derangements looked for.

Type
Research Article
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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References

Literature

1.Van den Hoofdakker, RH. Changing concepts in psychiatry; on therapy and pathogenesis in biological psychiatry. In: De Cuyper, H, Buyse, G, eds. Biological Psychiatry, Marching backwards into the Future. Leuven: Leuven University Press, 1989: 3962.Google Scholar
2.Kirk, SA, Kutchins, H. The selling of DSM. New York: Aldine De Gruyter, 1992.Google Scholar
3.Sartorius, N, Kaelber, CT, Cooper, JE. Progress toward achieving a common language in psychiatry. Arch gen Psychiat 1993; 50: 115–24.CrossRefGoogle ScholarPubMed
4.Williams, JBW, Gibbon, M, First, MB, et al.The structured clinical interview for DSM-III-R (SCID); II. Multisite test-retest reliability. Arch gen Psychiat 1992; 49: 630–6.CrossRefGoogle ScholarPubMed
5.Blashfield, RK. Comorbidity and classification. In: Maser, JD, Cloninger, CR, eds. Comorbidity of mood and anxiety disorders. Washington DC: American Psychiatric Press, 1990: 6182.Google Scholar
6.Frances, AJ, First, MB, Widiger, TA, et al.An A to Z guide to DSM-IV conumdrums. J abn Psychol 1991; 100: 407–12.CrossRefGoogle Scholar
7.Zinbarg, RE, Barlow, DH, Liebowitz, M, et al.The DSM-IV field trial for mixed anxiety-depression. Am J Psychiat 1994; 151:115362.Google ScholarPubMed
8.Kendell, RE. Clinical validity. Psychol Med 1989; 19: 4555.CrossRefGoogle ScholarPubMed
9.Mulder-Hajonides van der Meulen, WREH. Categories or dimensions? The use of diagnostic models in psychiatry. Groningen: Thesis, 1994.Google Scholar
10.Van Praag, HM. Diagnosis, the rate-limiting factor of biological depression research. Neuropsychobiology 1993; 28: 197206.CrossRefGoogle ScholarPubMed
11.Van Praag, HM. The DSM-IV (depression) classification: to be or not to be? (editorial) J nerv ment Dis 1990; 178: 147–9.CrossRefGoogle ScholarPubMed
12.Meehl, P. Some ruminations on the validation of clinical procedures. Can J Psychol 1959; 13: 102–28.CrossRefGoogle Scholar
13.Van den Burg, W, Bouhuys, AL, Van den Hoofdakker, RH. Self-rated arousal concurrent with the antidepressant response to total sleep deprivation of patients with a major depressive disorder: a disinhibition hypothesis. J Sleep Res 1992, 1: 211–22.CrossRefGoogle Scholar
14.Maas, JW, Katz, MM. Neurobiology and psychopathological states: are we looking in the right place? Biol Psychiat 1992; 31: 757–8.CrossRefGoogle ScholarPubMed
15.Van den Burg, W. In search of biological determinants of depressions. Groningen: Thesis, 1993.Google Scholar
16.Van den Burg, W. De werkzaamheid van antidepressiva; blikver-nauwing in de biologische psychiatrie. MGV 1994; 49: 1195–210.Google Scholar
17.Charlton, BG. A critique of biological psychiatry. Psychol Med 1990; 20: 36.CrossRefGoogle ScholarPubMed
18.Jacobs, BL. Serotonin and behavior: emphasis on motor control. J clin Psychiat 1991; 52: 12 (suppl): 1723.Google ScholarPubMed
19.Jacobs, BL. Serotonin, motor activity and depression-related disorders. Am Scient 1994; 82: 456–63.Google Scholar
20.Healy, D, Paykel, ES. Neurochemistry of mood disorders. In: Asbury, AK, McKhann, GM, McDonald, WI, eds. Diseases of the nervous System, Vol.1. Philadelphia: Saunders, 1992: 815–30.Google Scholar