Hostname: page-component-84b7d79bbc-g78kv Total loading time: 0 Render date: 2024-07-25T11:47:25.937Z Has data issue: false hasContentIssue false
  • English
  • Français

Psychological and neurophysiological dysfunctioning during wakefulness in narcolepsy

Published online by Cambridge University Press:  18 September 2015

J. Beullens  and
B. van Sweden
J. Beullens*
Affiliation:
Academisch Centrum voor Huisartsgeneeskunde, K.U. Leuven
B. van Sweden
Affiliation:
Afdeling Klinische Neurofysiologie en Slaap-/waakonderzoek, Medisch Centrum St. Jozef, Bilzen
*
Academisch Centrum voor Huisartsgeneeskunde, K.U. Leuven, Minderbroedersstraat 17, B-3000 Leuven, België
Get access Rights & Permissions [Opens in a new window]

Summary

Memory complaints and altered states of consciousness with automatic behaviour of narcoleptic patients indicate cognitive dysfunctioning. Although more problems arise while performing attention tasks than memory tasks, the neuropsychological test inquiry doesn't indicate one particular neuropsychological function as consistently impaired. They often perform well because they compensate impaired wakefulness by an increased willingness to respond. Neurophysiological research indicates that the sometimes occurring cognitive dysfunction is associated with a waxing and waning between wakefulness and sleep. The increased psychopathology is partly a reflection of, partly a reaction to the symptoms. The impact of hypersomnia on psychosocial functioning is more important than that of epilepsy in epileptics. In severe cases smoking and driving should better be dissuaded.

Keywords

narcolepsycognitionneuropsychologyneurophysiologypsychopathologynarcolepsiecognitieneuropsychologicneurofysiologiePsychopathologie
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 3 , September 1995 , pp. 95 - 105
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.Rosenthal, LD, Merlotti, L, Young, DK, Zorick, FJ, Wittig, RM, Roehrs, TA, Roth, T. Subjective and polysomnography characteristics of patients diagnosed with narcolepsy. Gen Hosp Psychiatry 1990; 12: 191–7.CrossRefGoogle ScholarPubMed
2.Aldrich, MS. Narcolepsy. N Engl J Med, 1990; 323: 389–94.Google ScholarPubMed
3.Mitler, MM, Hajdukovic, R, Erman, M, Koziol, JA. Narcolepsy. J clin Neurophysiol 1990; 7: 93–118.CrossRefGoogle ScholarPubMed
4.Verhoeven, WMA. Narcolepsie; een “slapend ziektebeeld”? Acta Neuropsychiat 1991; 3: 5–7.CrossRefGoogle Scholar
5.Van Sweden, B. Narcolepsie. Tijdschr Geneesk 1992; 48: 939–45.Google Scholar
6.Kales, A, Soldatos, CR, Bixler, EO, Caldwell, A, Cadieux, RJ, Verrechio, JM, Kales, JD. Narcolepsy-cataplexy. II. Psychosocial consequences and associated psychopathology. Arch Neurol 1982; 39: 169–71.CrossRefGoogle ScholarPubMed
7.Aldrich, MS. Automobile accidents in patients with sleep disorders. Sleep 1989; 12: 487–94.CrossRefGoogle ScholarPubMed
8.Douglas, AB, Hays, P, Pazderka, F, Russell, JM. Florid refractory schizophrenias that turn out te be treatable variants of HLA-associated narcolepsy. J nerv ment Dis 1991; 179: 12–7.CrossRefGoogle Scholar
9.Valley, V, Broughton, R. The physiological (EEG) nature of drowsiness and its relation to performance deficits in narcoleptics. Electroencephalogr clin Neurophysiol 1983; 55: 243–51.CrossRefGoogle ScholarPubMed
10.Aguirre, M, Broughton, R, Stuss, D. Does memory impairment exist in narcolepsy-cataplexy? J clin exp Neuropsychol 1985; 7: 14–24.CrossRefGoogle ScholarPubMed
11.Levander, S, Sachs, C. Vigilance performance and autonomic function in narcolepsy: effects of central stimulants. Psychophysiology 1985; 22: 24–31.CrossRefGoogle ScholarPubMed
12.Godbout, R, Montplaisir, J. All-day performance variations in normal and narcoleptic subjects. Sleep 1986; 9: 200–4.CrossRefGoogle ScholarPubMed
13.Rogers, AE, Rosenberg, RS. Tests of memory in narcoleptics. Sleep 1990; 13: 42–52.Google ScholarPubMed
14.Henry, GK, Satz, P, Heilbronner, RL. Evidence of a perceptual-encoding deficit in narcolepsy? Sleep 1993; 16: 123–7.CrossRefGoogle ScholarPubMed
15.Schulz, H, Wilde-Frenz, J. The disturbance of cognitive processes in narcolepsy. J Sleep Res 1995; 4: 10–4.CrossRefGoogle ScholarPubMed
16.Loiseau, P, Strube, E, Broustet, D, Battellochi, S, Gomeni, C, Morselli, PL. Learning impairment in epileptic patients. Epilepsia 1983; 24: 183–92.CrossRefGoogle ScholarPubMed
17.Beullens, J. Gaat narcolepsie gepaard met een geheugenstoornis? Een Literatuurstudie. Tijdschr Orthoped Kinderpsychiat klin Kin-derpsychol 1994; 19: 78–88.Google Scholar
18.Halgren, E, Smith, ME. Cognitive evoked potentials as modulatory processes in human memory formation and retrieval. Hum Neurobiol 1987; 6: 129–39.Google ScholarPubMed
19.Birbaumer, N, Elbert, T, Cavanan, AGM, Rockstroh, B. Slow potentials of the cerebral cortex and behavior. Physiol Rev 1990; 70: 1–41.CrossRefGoogle ScholarPubMed
20.Van Nunen, PEH, Declerck, AC. Cognitive function revealed by P300 in patients suffering from EDS or epilepsy. In: Coenen, A, ed. Sleep-wake Research in the Netherlands. Utrecht: Elinkwijk, 1993: 161–6.Google Scholar
21.Teyler, TJ, DiScenna, P. The hippocampal memory indexing theory. Behav Neurosci 1986; 100: 147–54.CrossRefGoogle ScholarPubMed
22.Meador, KJ, Loring, DW, King, DW, Gallagher, BB, Gould, MJ, Flanigin, HF, Smith, JR. Limbic evoked potentials predict site of epileptic focus. Neurology 1987; 37: 494–7.CrossRefGoogle ScholarPubMed
23.Puce, A, Kalnins, R, Berkovic, SF, Donnan, GA, Bladin, PF. Limbic P3 potentials, seizure localization, and surgical pathology in temporal lobe epilepsy. Ann Neurol 1989; 26: 377–85.CrossRefGoogle ScholarPubMed
24.Broughton, RJ, Aguirre, M. Differences between REM and NREM sleepiness measured by event-related potentials (P300, CNV), MSLT and subjective estimate in narcolepsy-cataplexy. Electroencephalogr clin Neurophysiol 1987; 67: 317–26.CrossRefGoogle ScholarPubMed
25.Dodrill, CR. Neuropsychology of epilepsy. In: Filskov, SB, Boll, TJ, eds. Handbook of Clinical Neuropsychology. New York: John Wiley and Sons, 1981: 366–95.Google Scholar
26.Webb, WB, Agnew, HW. The effects of a chronic limitation of sleep length. Psychophysiol 1974; 11: 265–74.CrossRefGoogle ScholarPubMed
27.Volk, S, Simon, O, Schulz, H, Hansert, E, Wilde-Frenz, J. The structure of wakefulness and its relationship to daytime sleep in narcoleptic patients. Electroencephalogr clin Neurophysiol 1984; 57: 119–28.CrossRefGoogle ScholarPubMed
28.Dantz, B, Edgar, DM, Dement, WC. Circadian rhythms in narcolepsy: studies on a 90 minute day. Electroencephalogr clin Neurophysiol 1994; 90: 24–35.CrossRefGoogle ScholarPubMed
29.Amira, SA, Johnson, TS, Logowitz, MB. Diagnosis of narcolepsy using the MSLT: analysis of current laboratory criteria. Sleep 1985;8:325–31.CrossRefGoogle ScholarPubMed
30.Mignot, E, Mishimo, S, Valtier, D, Renand, A, Guilleminault, C, Dement, WC. Pharmacological control of narcolepsy. In: Home, J, ed. Sleep '90. Bochum: Pontenagel Press, 1990: 409–15.Google Scholar
31.Hermann, BP, Whitman, S. Behavioral and personality correlates of epilepsy: a review, methodological critique and conceptual model. Psychol Bull 1984; 95: 451–97.CrossRefGoogle ScholarPubMed
32.Broughton, RJ, Guberman, A, Roberts, J. Comparison of the psychosocial effects of epilepsy and narcolepsy/cataplexy: a controlled study. Epilepsia 1984; 25: 423–33.CrossRefGoogle ScholarPubMed
33.Roy, A. Psychiatric aspects of narcolepsy. Br J Psychiat 1976; 128: 562–5.CrossRefGoogle ScholarPubMed
34.Sachs, C, Levander, S. Personality traits in patients with narcolepsy. Pers Indiv Diff 1981; 2: 319–24.CrossRefGoogle Scholar
35.Okawa, M, Matousek, M, Petersen, I. Spontaneous vigilance fluctuations in the daytime. Psychophysiol 1984; 21: 207–11.CrossRefGoogle ScholarPubMed