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Panic disorder and depression: relationship between psychological and biochemical aspects

Published online by Cambridge University Press:  24 June 2014

L. Timmerman
L. Timmerman*
Affiliation:
Department of General Hospital Psychiatry, Deventer, the Netherlands
*
L. Timmerman, Adhesie, Postbox 5003, 7400 GC Deventer, the Netherlands. E-mail: L.Timmerman@adhesie.nl
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Abstract

In a group of medication-free out-patients suffering from depression and/or panic disorder we investigated the interdependence between psychological parameters such as aggression and biochemical parameters such as serotonin and tryptophan. We compared the findings in the patient group with a reference group. In the group of patients as a whole negative correlations were observed between the concentration of serotonin in platelets and depression and with hostility and aggression against others. Serotonin in plasma and tryptophan correlated negatively with hostility. The findings support the suggested link between aggression and depression with a low functioning serotonergic system.

Keywords

Aggressiondepressionpanic disorderserotonintrytophan
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 1 , February 2003 , pp. 26 - 31
Copyright
Copyright © 2003 Blackwell Munksgaard

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References

Ball, WA & Whybrow, PC.Biology of depression and mania. Curr Opin Psychiatry 1993;6: 27–34. CrossRefGoogle Scholar
Moller, SA, De Beurs, P, Timmerman, L.Plasma tryptophan and tyrosine ratios to competing amino acids in relation to antidepressant response to citalopram and maprotiline. Psychopharmacology 1986;88: 96–100.CrossRefGoogle Scholar
Leonard, BE.Peripheral markers of depression. Curr Opin Psychiatry 2000;13: 61–68. CrossRefGoogle Scholar
Green, RA, Costain, DW. Pharmacology and biochemistry of psychiatric disorders. Chicester: J. Wiley & Sons, 1981. Google Scholar
Den Boer, JA, Westenberg, HGM, Kamerbeek, WDJ.Effect of serotonin uptake inhibitors in anxiety disorders: a double blind comparison of clomipramine and fluvoxamine. Int Clin Psychopharmacol 1987;2: 21–32.CrossRefGoogle ScholarPubMed
Timmerman, L, De Beurs, P, Tan, BK.A double blind comparative clinical trial of citalopam vs maprotiline in hospitalized depressed patients. Int Clin Psychopharmacol 1987;2: 239–253.CrossRefGoogle Scholar
Timmerman, L, Verhey, R, Fekkes, D.Norharman and platelet serotonin in panic disorder patients compared with healthy controls. Eur Neuropsychopharmacol 1994;4: 353–354. CrossRefGoogle Scholar
Kahn, RS, Van Praag, HM.Serotonin and anxiety revisited. Biol Psychiatry 1992;23: 189–208. CrossRefGoogle Scholar
Fekkes, D, Timmerman, L, Pepplinkhuizen, L.Effects of clomipramine on aminoacids and serotonergic parameters in panic disorders and depression. Eur Neuropsychopharmacol 1997;7: 235–239.CrossRefGoogle ScholarPubMed
Derogotis, LR, Lipman, RS, Covi, L.SCL-90: an out-patient psychiatric rating scale, preliminary report. Psychopharmacol Bull 1973;9: 13–27.Google Scholar
Arrindell, WA, Ettema, H.Handleiding bij een multidimensionele psychopathologie indicator[Dutch language manual of the SCL 90]. Lisse: Swets and Zeitlinge, 1986. Google Scholar
Gleser, GC, Jhilevich, D.An objective instrument for measuring defense mechanisms. J Consult Clin Psychol 1969;33: 51–6013.CrossRefGoogle ScholarPubMed
Ihilevich, D, Gleser, GC.Defense mechanisms: their classification, correlates and measurement with the Defense Mechanism Inventory. Owosso: DMI Associates, 1986. Google Scholar
Schreurs, PJG, Tellegen, B, Health, WA.Stress and coping: the development of the Utrechtse Coping Scale. Tijdschr Psychologie 1984;1/2: 101–117. Google Scholar
Passchier, J, Verhage, F.The defense mechanism inventory: preliminary findings on reliability and validity of the Dutch translation. Gedrag Gezondheid 1986;14: 119–124. Google Scholar
Hiller, W, Zaudig, M, Mittelkammer, J.The Munich Diagnostic Checklist (MDCL). Munich: Max Planck Institute of psychiatry, 1987. Google ScholarPubMed
June, S, Yanishevsky, DS.Defense style: state or trait. J Pers Assess 1983;47: 536–538.CrossRefGoogle Scholar
Schreurs, PJG.Persoonlijkheidskenmerken essentiele hypertensie. Thesis. Maastricht: Rijksuniversiteit Limburg, 1987. Google Scholar
Spitzer, RL, William, JB.Structural Clinical Interview for DSM-III-R (SCID). New York: Biometrics Research Department Psychiatric Institute, 1987. Google Scholar
Timmerman, L.Panic disorder, a specific clinical entity? Thesis. the Netherlands: Van Es, Spijkenisse, 1995. Google Scholar
Pletcher, A.Platelets as models for monoaminergic neurons. In: Youdim, MBHet al., eds. Essays in neurochemistry and neuropharmacology. Chichester: Wiley, 1981. Google Scholar
Brown, GL, Goodwin, FK, Ballenger, JC.Aggression in humans correlates with cerebrospinal fluid metabolites. Psychiatr Res 1979;1: 131–139. CrossRefGoogle Scholar
Much-Seler, D, Deanovic, Z, Jamnichy, B.Maprotiline in the treatment of endogenous depression: comparison of the therapeutic effect with serotonin level in blood platelets. Psychopharmacology 1983;78: 262–265. CrossRefGoogle Scholar
Praag, HM.The future of biological psychiatry. Acta Neuropsychiatrica 1995;7: 24–29. Google Scholar
Glas, G.Concepten van angst en angststoornissen.Thesis. Lisse, Amsterdam: Swets & Zeitlinger, 1991. Google Scholar
Roy-Byrne, PP, Vitaliano, PP, Cowley, DS.Coping in panic and major depressive disorder. J Nerv Ment Dis 1992;180: 179–183.CrossRefGoogle ScholarPubMed