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De novo Tardive Tourette‐like syndrome after prolonged combination depot and oral neuroleptic therapy

Published online by Cambridge University Press:  21 February 2013

Jegan Yogaratnam ,
Changqing Xu ,
Daw San San Thinn ,
Lee Kim Yoong ,
Chai Ling Khoo  and
Kang Sim
Jegan Yogaratnam
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
Changqing Xu
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
Daw San San Thinn
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
Lee Kim Yoong
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
Chai Ling Khoo
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
Kang Sim*
Affiliation:
Woodbridge Hospital/Institute of Mental Health, Singapore, Singapore
*
Associate Professor Kang Sim, Woodbridge Hospital/Institute of Mental Health, 10 Buangkok View, Singapore 539747, Singapore. Tel: (65) 63892000 Fax: (65) 63855900 E‐mail: kang_sim@imh.com.sg
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Abstract

Introduction

Tardive Tourette‐like syndrome is recognised by the observation of several motor and vocal tics often in individuals receiving psychotropic medications and can happen within 1–3 months of treatment.

Clinical case

We report a case which is unique in its onset of Tardive Tourette‐like syndrome comprising of vocal, motor tics and coprolalia after more than three decades of treatment with combination depot and oral neuroleptics.

Discussion

Use of the Naranjo Adverse Drug Reaction Probability Scale indicates a probable relationship between the onset of Tardive Tourettism and the antipsychotic therapy in this patient. This was in contrast to earlier reports which noted earlier onset and partial reversal with termination or change of medications. Clinicians need to pay heed to the emergence of late‐onset Tourettism in order to better manage its manifestation and prevent its worsening in the context of holistic care for patients with neuropsychiatric conditions including schizophrenia.

Keywords

late onsetneuroleptic therapyTardive Tourette syndrome
Type
Case Report
Information
Acta Neuropsychiatrica , Volume 25 , Issue 2 , April 2013 , pp. 122 - 124
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013

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