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Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study

Published online by Cambridge University Press:  24 June 2014

Shuang Ge Sui ,
Ming Xiang Wu ,
Mark E. King ,
Yan Zhang ,
Li Ling ,
Jian Min Xu ,
Xu Chu Weng ,
Lian Duan ,
Bao Ci Shan  and
Ling Jiang Li
Shuang Ge Sui
Affiliation:
Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China
Ming Xiang Wu
Affiliation:
ShenZhen People's Hospital, Guangdong 518020, P. R. China
Mark E. King
Affiliation:
Faculty of Education, The University of Hong Kong, HHSAR, P. R. China
Yan Zhang
Affiliation:
Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China
Li Ling
Affiliation:
Faculty of Education, The University of Hong Kong, HHSAR, P. R. China
Jian Min Xu
Affiliation:
ShenZhen People's Hospital, Guangdong 518020, P. R. China
Xu Chu Weng
Affiliation:
Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing100012, P. R. China
Lian Duan
Affiliation:
Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China
Bao Ci Shan*
Affiliation:
Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China
Ling Jiang Li*
Affiliation:
Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China
*
Bao Ci Shan, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. Tel: +86 13693161965; Fax: +86 10 88233186; E-mail: shanbc@ihep.ac.cn
Ling Jiang Li, Mental Health Institute, Second Xiangya Hospital, Central-South University, Changsha, Hunan 410011, P. R. China. Tel: +86 13807314575; Fax:+86 731 85360086; E-mail: llj2920@163.com
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Abstract

Sui SG, Wu MX, King ME, Zhang Y, Ling L, Xu JM, Weng XC, Duan L, Shan BC, Li LJ. Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study.

Objective:

This study examined changes in brain grey matter in victims of rape (VoR) with and without post-traumatic stress disorder (PTSD). Previous research has focused on PTSD caused by various traumatic events, such as war and disaster, among others. Although considerable research has focused on rape-related PTSD, limited studies have been carried out in the context of Mainland China.

Methods:

The study included 11 VoR with PTSD, 8 VoR without PTSD and 12 healthy comparison (HC) subjects. We used voxel-based morphometry to explore changes in brain grey-matter density (GMD) by applying statistical parametric mapping to high-resolution magnetic resonance images.

Results:

Compared with HC, VoR with PTSD showed significant GMD reductions in the bilateral medial frontal cortex, left middle frontal cortex, middle temporal gyrus and fusiform cortex and significant GMD increases in the right posterior cingulate cortex, postcentral cortex, bilateral precentral cortex and inferior parietal lobule. Compared to VoR without PTSD, VoR with PTSD showed significant GMD reductions in the right uncus, left middle temporal gyrus, and the fusiform cortex, and increases in the left precentral cortex, inferior parietal lobule and right post-central cortex.

Conclusion:

The findings of abnormal GMD in VoR with PTSD support the hypothesis that PTSD is associated with widespread anatomical changes in the brain. The medial frontal cortex, precentral cortex, posterior cingulate cortex, post-central cortex and inferior parietal lobule may play important roles in the neuropathology of PTSD.

Keywords

ChinaMRIpost-traumatic stress disorderrapevoxel-based morphometry
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 3 , June 2010 , pp. 118 - 126
Copyright
Copyright © 2010 John Wiley & Sons A/S

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References

Miller, L.Atypical psychological responses to traumatic brain injury: PTSD and beyond. Neurorehabilitation 1999; 13:79–90. CrossRefGoogle Scholar
Kasai, K, Yamasue, H, Araki, T, Sakamoto, H, Kato, N.Structural and functional neuroimaging in posttraumatic stress disorder. In: PTSD: brain mechanisms and clinical implications. Japan: Springer, 2006, pp 203–209. CrossRefGoogle Scholar
Danckwerts, A, Leathem, J.Questioning the link between PTSD and cognitive dysfunction. Neuropsychol Rev 2003; 13:221–235. CrossRefGoogle ScholarPubMed
Bremner, JD, Charney, DS.Neurobiology of posttraumatic stress disorder—implications for treatment. Int Acad Biomed Drug Res 1994; 8:171–186. Google Scholar
Sareen, J, Cox, BJ, Stein, MB, Afifi, TO, Fleet, C, Asmundson, GJG.Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom Med 2007;69:242–248. CrossRefGoogle Scholar
Nemeroff, CB, Bremner, JD, Foa, EB, Mayberg, HS, North, CS, Stein, MB.Posttraumatic stress disorder: A state-of-the-science review. J Psychiatr Res 2006;40:1–21. CrossRefGoogle ScholarPubMed
Shin, LM, Rauch, SL, Pitman, RK.Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann N Y Acad Sci 2006;1071:67–79. CrossRefGoogle ScholarPubMed
Liberzon, I, Sripada, CS.The functional neuroanatomy of PTSD: a critical review. Stress hormones and post traumatic stress disorder: basic studies and clinical perspectives 2008;167:151–169. Google ScholarPubMed
Geuze, E, Vermetten, E, Bremner, JD.MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Mol Psychiatry 2005;10:160–184. CrossRefGoogle ScholarPubMed
Geuze, E, Vermetten, E, Goebel, R, Westenberg, H.Thinner prefrontal cortex in veterans with posttraumatic stress disorder. Biol Psychiatry 2008;63:174S–174S. Google Scholar
Gilbertson, M, Shenton, M, Ciszewski, Aet al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 2002;5:1242–1247. CrossRefGoogle ScholarPubMed
Villarreal, G, King, CY.Neuroimaging studies reveal brain change in posttraumatic stress disorder. Psychiatr Ann 2004;34:845–856. CrossRefGoogle Scholar
Bossini, L, Castrogiovanni, P.Pre- and posttreatment neuroimaging of PTSD: focus on hippocampal volume. J Psychosom Res 2007;63:310. Google Scholar
Bremner, JD, Vythilingam, M, Vermetten, Eet al. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biol Psychiatry 2003;53:879–889. CrossRefGoogle ScholarPubMed
Emdad, R, Bonekamp, D, Sondergaard, HPet al. Morphometric and psychometric comparisons between non-substance- abusing patients with posttraumatic stress disorder and normal controls. Psychother Psychosom 2006;75:122–132. CrossRefGoogle ScholarPubMed
Lindauer, RJL, Vlieger, EJ, Jalink, Met al. Smaller hippocampal volume in dutch police officers with posttraumatic stress disorder. Biol Psychiatry 2004;56:356–363. CrossRefGoogle ScholarPubMed
Vythilingam, M, Luckenbaugh, DA, Lam, Tet al. Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder. Psychiatry Res Neuroimaging 2005;139:89–99. CrossRefGoogle ScholarPubMed
Li, LJ, Chen, SL, Li, J, Zhang, JL, He, Z, Lin, X.Magnetic resonance imaging and magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder. Can J Psychiatry 2006;51:431–437. CrossRefGoogle ScholarPubMed
Bremner, JD, Randall, P, Scott, TMet al. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic-stress-disorder. Am J Psychiatry 1995;152:973–981. Google ScholarPubMed
Gurvits, TV, Shenton, ME, Hokama, Het al. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry 1996;40:1091–1099. CrossRefGoogle ScholarPubMed
Fennema-Notestine, C, Stein, MB, Kennedy, CM, Archibald, SL, Jernigan, TL.Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biol Psychiatry 2002;52: 1089–1101. CrossRefGoogle ScholarPubMed
Jatzko, A, Rothenhofer, S, Schmitt, Aet al. Hippocampal volume in chronic posttraumatic stress disorder (PTSD): MRI study using two different evaluation methods. J Affect Disord 2006;94:121–126. CrossRefGoogle ScholarPubMed
Golier, JA, Harvey, PD, Legge, J, Yehuda, R.Memory performance in older trauma survivors—implications for the longitudinal course of PTSD, vol. 1071, Psychobiology of posttraumatic stress disorder: a decade of progress 2006: 54–66. Google ScholarPubMed
Winter, H, Irle, E.Hippocampal volume in adult burn patients with and without posttraumatic stress disorder. Am J Psychiatry 2004;161:2194–2200. CrossRefGoogle ScholarPubMed
Tupler, LA, De Bellis, MD.Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder. Biol Psychiatry 2006;59:523–529. CrossRefGoogle ScholarPubMed
Karl, A, Schaefer, M, Malta, LS, Dorfel, D, Rohleder, N, Werner, A.A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 2006;30: 1004–1031. CrossRefGoogle ScholarPubMed
Milad, MR, Rauch, SL, Pitman, RK, Quirk, GJ.Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biol Psychology 2006;73:61–71. CrossRefGoogle ScholarPubMed
Carrion, VG, Weems, CF, Eliez, Set al. Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biol Psychiatry 2001;50:943–951. CrossRefGoogle ScholarPubMed
Richert, KA, Carrion, VG, Karchemskiy, A, Reiss, AL.Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study. Depress Anxiety 2006;23:17–25. CrossRefGoogle ScholarPubMed
Hakamata, Y, Matsuoka, Y, Inagaki, Met al. Structure of orbitofrontal cortex and its longitudinal course in cancer-related post-traumatic stress disorder. Neurosci Res 2007;59:383–389. CrossRefGoogle ScholarPubMed
Bonne, O, Gilboa, A, Louzoun, Yet al. Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biol Psychiatry 2003;54:1077–1086. CrossRefGoogle ScholarPubMed
Lanius, RA, Williamson, PC, Bluhm, RLet al. Functional connectivity of dissociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigation. Biol Psychiatry 2005;57:873–884. CrossRefGoogle ScholarPubMed
Molina, ME, Isoardi, R, Prado, MN, Bentolila, S.Basal cerebral glucose distribution in long-term post-traumatic stress disorder. World J Biol Psychiatry 2007;13:1–9. CrossRefGoogle Scholar
Bremner, JD.Traumatic stress: effects on the brain. Dialogues Clin Neurosci 2006;8:445–461. CrossRefGoogle ScholarPubMed
Bremner, JD, Elzinga, B, Schmahl, C, Vermetten, E.Structural and functional plasticity of the human brain in posttraumatic stress disorder, vol. 167, Stress hormones and post traumatic stress disorder: basic studies and clinical perspectives. 2008: 171–186. Google ScholarPubMed
Geuze, E, Westenberg, HGM, Heinecke, A, De Kloet, CS, Goebel, R, Vermetten, E.Thinner prefrontal cortex in veterans with posttraumatic stress disorder. Neuroimage 2008;41:675–681. CrossRefGoogle ScholarPubMed
Corbo, V, Clement, MH, Armony, JL, Pruessner, JC, Brunet, A.Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biol Psychiatry 2005;58:119–124. CrossRefGoogle ScholarPubMed
Kasai, K, Yamasue, H, Gilbertson, MW, Shenton, ME, Rauch, SL, Pitman, RK.Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biol Psychiatry 2008;63:550–556. CrossRefGoogle ScholarPubMed
Luders, E, Gaser, C, Jancke, L, Schlaug, G.A voxel-based approach to gray matter asymmetries. Neuroimage 2004;22:656–664. CrossRefGoogle ScholarPubMed
Pavic, L, Gregurek, R, Rados, Met al. Smaller right hippocampus in war veterans with posttraumatic stress disorder. Psychiatry Res Neuroimaging 2007;154:191–198. CrossRefGoogle ScholarPubMed
Abe, O, Yamasue, H, Kasai, Ket al. Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism. Psychiatry Res Neuroimaging 2006;146:231–242. CrossRefGoogle ScholarPubMed
Li, LJ, Chen, SL, Liu, J, Zhang, JL, He, Z, Lin, X.Magnetic resonance imaging a magnetic resonance spectroscopy study of deficits in hippocampal structure in fire victims with recent-onset posttraumatic stress disorder. Can J Psychiatry 2006;51:431–437. CrossRefGoogle ScholarPubMed
Yamasue, H, Kasai, K, Iwanami, Aet al. Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proc Natl Acad Sci U S A 2003;100:9039–9043. CrossRefGoogle ScholarPubMed
Tjaden, P, Thoennes, N.Full report of the prevalence, incidence, and consequences of violence against women. Washington, National Institute of Justice, 2000. CrossRefGoogle Scholar
Rothbaum, BO, Foa, EB, Riggs, DS, Murdock, T, Walsh, W.A prospective examination of posttraumatic-stress-disorder in rape victims. J Trauma Stress 1992;5: 455–475. Google Scholar
Green, BL.Trauma history questionnaire. In: Stamm, BH ed. Measurement of stress, trauma, and adaptation Luther-ville: Sidran Press, 1996, pp 366–369. Google Scholar
Ruggiero, KJ, Ben, KD, Scotti, JR, Rabalais, AE.Psychometric properties of the PTSD checklist—civilian version. J Trauma Stress 2003;16:495–502. CrossRefGoogle ScholarPubMed
Blake, DD, Weathers, FW, Nagy, LMet al. The development of a clinician-administered PTSD scale. J Trauma Stress 1995;8:75–90. Google ScholarPubMed
Friston, KJ, Holmes, AP, Worsley, KJ, Poline, JB, Frith, CD, Frackowiak, RSJ.Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 1995;2:189–210. CrossRefGoogle Scholar
Mazziotta, JC, Toga, AW, Evans, A, Fox, P, Lancaster, J.A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage 1995;2: 89–101. CrossRefGoogle Scholar
Ashburner, J, Friston, KJ.Voxel-based morphometry—the methods. Neuroimage 2000;11:805–821. CrossRefGoogle ScholarPubMed
Liberzon, I, King, AP, Britton, JC, Phan, KL, Abelson, JL, Taylor, SF.Paralimbic and medial prefrontal cortical involvement in neuroendocrine responses to traumatic stimuli. Am J Psychiatry 2007;164:1250–1258. CrossRefGoogle ScholarPubMed
Hou, CL, Liu, J, Wang, Ket al. Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. Brain Res 2007;1144:165–174. CrossRefGoogle ScholarPubMed
Bremner, JD, Staib, LH, Kaloupek, D, Southwick, SM, Soufer, R, Charney, DS.Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biol Psychiatry 1999;45:806–816. CrossRefGoogle ScholarPubMed
Lanius, RA, Bluhm, R, Lanius, U, Pain, C.A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation. J Psychiatr Res 2006;40:709–729. CrossRefGoogle ScholarPubMed
Lanius, RA, Williamson, PC, Densmore, Met al. The nature of traumatic memories: a 4-T fMRI functional connectivity analysis. Am J Psychiatry 2004;161:36–44. CrossRefGoogle ScholarPubMed
Lindauer, RJL, Booij, J, Habraken, JBAet al. Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder. Biol Psychiatry 2004;56:853–861. CrossRefGoogle ScholarPubMed
Lindauer, RJL, Booij, J, Habraken, JBAet al. Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial. Psychol Med 2008;38:543–554. CrossRefGoogle ScholarPubMed
Morey, RA, Petty, CM, Cooper, DA, Labar, KS, McCarthy, G.Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans. Psychiatry Res Neuroimaging 2008;162:59–72. CrossRefGoogle ScholarPubMed
Tanji, J.The supplementary motor area in the cerebral-cortex. Neurosci Res 1994;19:251–268. CrossRefGoogle ScholarPubMed
Duffau, H, Capelle, L, Denvil, Det al. The role of dominant premotor cortex in language: a study using intraoperative functional mapping in awake patients. Neuroimage 2003;20:1903–1914. CrossRefGoogle Scholar
Shaw, ME, Strother, SC, McFarlane, ACet al. Abnormal functional connectivity in posttraumatic stress disorder. Neuroimage 2002;15:661–674. CrossRefGoogle ScholarPubMed
Jatzko, A, Schmitt, A, Demirakca, T, Weimer, E, Braus, D.Disturbance in the neural circuitry underlying positive emotional processing in post-traumatic stress disorder (PTSD)—an fMRI study. Eur Arch Psychiatry Clin Neurosci 2006;256:112–114. CrossRefGoogle ScholarPubMed
Xie, S, Xiao, JX, Bai, J, Jiang, XX.Memory tasks in normal aged volunteers: an fMRI study. China J Med Imaging Technol 2004;20:571–574. Google Scholar
Knauff, M, Mulack, T, Kassubek, J, Salih, HR, Greenlee, MW.Spatial imagery in deductive reasoning: a functional MRI study. Cogn Brain Res 2002;13:203–212. CrossRefGoogle ScholarPubMed
Geng, JJ, Eger, E, Ruff, CC, Kristjansson, A, Rotshtein, P, Driver, J.On-line attentional selection from competing stimuli in opposite visual fields: effects on human visual cortex and control processes. J Neurophysiol 2006; 96:2601–2612. CrossRefGoogle ScholarPubMed
Geuze, E, Vermetten, E, Ruf, M, De Kloet, CS, Westenberg, HGM.Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder. J Psychiatr Res 2008;42:659–669. CrossRefGoogle ScholarPubMed
Farrow, TFD, Hunter, MD, Wilkinson, IDet al. Quantifiable change in functional brain response to empathic and forgivability judgments with resolution of posttraumatic stress disorder. Psychiatry Res: Neuroimaging 2005;140:45–53. CrossRefGoogle ScholarPubMed
Rossion, B, Dricot, L, Devolder, Aet al. Hemispheric asymmetries for whole-based and part-based face processing in the human fusiform gyrus. J Cogn Neurosci 2000;12:793–802. CrossRefGoogle ScholarPubMed
Rhodes, G, Byatt, G, Michie, PT, Puce, A.Is the fusiform face area specialized for faces, individuation, or expert individuation? J Cogn Neurosci 2004;16:189–203. CrossRefGoogle ScholarPubMed
Nielsen, FA, Balslev, D, Hansen, LK.Mining the posterior cingulate: segregation between memory and pain components. Neuroimage 2005;27:520–532. CrossRefGoogle ScholarPubMed
Doronbekov, TK, Tokunaga, H, Ikejiri, Yet al. Neural basis of fear conditioning induced by video clip: positron emission tomography study. Psychiatry Clin Neurosci 2005;59:155–162. CrossRefGoogle ScholarPubMed
Sachinvala, N, Kling, A, Suffin, S, Lake, R, Cohen, M.Increased regional cerebral perfusion by Tc-99m hexamethyl propylene amine oxime single photon emission computed tomography in post-traumatic stress disorder. Mil Med 2000;165:473–479. CrossRefGoogle ScholarPubMed
Bremner, JD, Narayan, M, Staib, LH, Southwick, SM, McGlashan, T, Charney, DS.Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 1999;156:1787–1795. CrossRefGoogle ScholarPubMed