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  • Print publication year: 2010
  • Online publication date: November 2010

8 - The origin of life: a review of facts and speculation

Summary

The problem of the origin of life on the Earth has much in common with a well-constructed detective story. There is no shortage of clues pointing to the way in which the crime, the contamination of the pristine environment of the early Earth, was committed. On the contrary, there are far too many clues and far too many suspects. It would be hard to find two investigators who agree on even the broad outline of the events that occurred so long ago and made possible the subsequent evolution of life in all its variety. Here, I outline two of the main questions and some of the conflicting evidence that has been used in attempts to answer them. First, however, I summarize the few areas where there is fairly general agreement.

The Earth is slightly more than 4.5 billion years old. For the first half billion years or so after its formation, it was impacted by objects large enough to evaporate the oceans and sterilize the surface. Well-preserved microfossils of organisms that have morphologies similar to those of modern blue-green algae, and date back about 3.5 billion years, have been found, and indirect but persuasive evidence supports the proposal that life was present 3.8 billion years ago. Life, therefore, originated on or was transported to the Earth at some point within a window of a few hundred million years that opened about four billion years ago.

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References
Sleep, N. H., Zahnle, K. J., Kasting, J. F., & Morowitz, H. J. (1989). Annihilation of ecosystems by large asteroid impacts on early Earth. Nature, 342, 139–142.
Chyba, C. F. (1993). The violent environment of the origin of life: Progress and uncertainties. Geochimica et Cosmochimica Acta, 57, 3351–3358.
Schopf, J. W. (1993). The Earth's earliest biosphere: Its origin and evolution. Princeton, NJ: Princeton University Press.
Mojzsis, S. J., Arrhenius, G., McKeegan, K. D., Harrison, T. M., Nutman, A. P., & Friend, C. R. (1996). Evidence for life on Earth before 3,800 million years ago. Nature, 384, 55–59.
Feng, D.-F., Cho, G., & Doolittle, R. F. (1997). Determining divergence times with a protein clock: Update and reevaluation. Proceedings of the National Academy of Sciences, 94, 13,028–13,033.
Miller, S. L. (1953). A production of amino acids under possible primitive Earth conditions. Science, 117, 528–529.
Ring, D., Wolman, Y., Friedmann, N., & Miller, S. L. (1972). Prebiotic synthesis of hydrophobic and protein amino acids. Proceedings of the National Academy of Sciences, 69, 765–768.
Wolman, Y., Haverland, H., & Miller, S. L. (1972). Nonprotein amino acids from spark discharges and their comparison with the Murchison meteorite amino acids. Proceedings of the National Academy of Sciences, 69, 809–811.
Oro, J. (1960). Synthesis of adenine from ammonium cyanide. Biochemical and Biophysical Research Communications, 2, 407–412.
Ferris, J. P., Sanchez, A., & Orgel, L. E. (1968). Studies in prebiotic synthesis III. Synthesis of pyrimidines from cyanoacetylene and cyanate. Journal of Molecular Biology, 33, 693–704.
Butlerow, A. (1861). Formation synthétique d'une substance sucrée. Comptes Rendus de l' Académie des Sciences, 53, 145–147.
Butlerow, A. (1861). Bildung einer zuckerartingen Substanz durch Synthese. Justus Liebigs Annalen der Chemie, 120, 295–298.
Kasting, J. F. (1993). Earth's early atmosphere. Science, 259, 920–926.
Cronin, J. R., Pizzarella, S., & Crukshank, D. P. (1988). Organic matter in carbonaceous chondrites, planetary satellites, asteroids and comets. In Kerridge, J. F. & Matthew, M. S. (Eds.), Meteorites and the early solar system (pp. 819–857). Tuscan, AZ: University of Arizona Press.
Chyba, C. & Sagan, C. (1992). Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: An inventory for the origins of life. Nature, 355, 125–132.
Wächtershäuser, G. (1988). Before enzymes and templates: Theory of surface metabolism. Microbiological Reviews, 52, 452–484.
Wächtershäuser, G. (1992). Groundworks for an evolutionary biochemistry: The iron-sulfur world. Progress in Biophysics and Molecular Biology, 58, 85–201.
Blöchl, E., Keller, M., Wächtershäuser, G., & Stetter, K. O. (1992). Reactions depending on iron sulfide and linking geochemistry with biochemistry. Proceedings of the National Academy of Sciences, 89, 8117–8120.
Huber, C. & Wächtershäuser, G. (1997). Activated acetic acid by carbon fixation on (Fe,Ni)S under primordial conditions. Science, 276, 245–247.
Gesteland, R. F. & Atkins, J. F. (1993). The RNA world: The nature of modern RNA suggests a prebiotic world. Long Island, NY: Cold Spring Harbor Laboratory Press.
Pan, T. (1997). Novel and variant ribozymes obtained through in vitro selection. Current Opinion in Chemical Biology, 1, 17–25.
Breaker, R. R. (1997). DNA aptamers and DNA enzymes. Current Opinion in Chemical Biology, 1, 26–31.
Eklund, E. H., Szostak, J. W., & Battel, D. P. (1995). Structurally complex and highly active RNA ligases derived from random RNA sequences. Science, 269, 364–370.
Eklund, E. H. & Bartel, D. P. (1996). RNA-catalysed RNA polymerization using nucleoside triphosphates. Nature, 382, 373–376.
Unrau, P. J. & Bartel, D. P. (1998). RNA-catalysed nucleotide synthesis. Nature, 395, 260–263.
Ferris, J. P. & Ertem, G. (1993). Montmorillonite catalysis of RNA oligomer formation in aqueous solution: A model for the prebiotic formation of RNA. Journal of the American Chemical Society, 115, 12,270–12,275.
Kawamura, K. & Ferris, J. P. (1994). Kinetic and mechanistic analysis of dinucleotide and oligonucleotide formation from the 5′-phosphorimidazolide of adenosine on NA+-montmorillonite. Journal of the American Chemical Society, 119, 7564–7572.
Hill, A. R., Wu, T., & Orgel, L. E. (1993). The limits of template-directed synthesis with nucleoside-5′-phosphoro(2-methyl)imidazolides. Origins of Life and Evolution of the Biosphere, 23, 285–290.
Orgel, L. E. (1994). The origin of life on Earth. Scientific American, 271, 52–61.
Ferris, J. P. (1987). Prebiotic synthesis: Problems and challenges. Cold Spring Harbor Symposia on Quantitative Biology, LII, 29–39.
Joyce, G. F., Visser, G. M., Boeckel, A. A., Boom, J. H., Orgel, L. E., & Westrenen, J. (1984). Nature, 310, 602–604.
Müller, D., Pitsch, S., Kittaka, A., et al. (1990). Chimie von a-Aminonitrilen. Aldomerisierung von Glycolaldehyd-phosphat zu racemischen Hexose-2,4,6-triphosphaten und (in Gegenwart von Formaldehyd) racemischen Pentose-2,4-diphosphaten: Rac-Allose-2,4,6-triphosphat und rac-Ribose-2,4-diphosphat sind die Reaktionshauptprodukte. Helvetica Chimica Acta, 73, 1410–1463.
Cairns-Smith, A. G. (1982). Genetic takeover and the mineral origins of life. Cambridge, UK: Cambridge University Press.
Cairns-Smith, A. G. & Davis, C. J. (1997). The design of novel replicating polymers. In Duncan, R. and Weston-Smith, M. (Eds.), Encyclopaedia of ignorance (pp. 397–403). New York: Pergamon Press.
Eschenmoser, A. (1997). Towards a chemical etiology of nucleic acid structure. Origins of Life and Evolution of the Biospheres, 27, 535–553.
Egholm, M., Buchardt, O., Nielsen, P. E., & Berg, R. H. (1992). Peptide of nucleic acids (PNA): Oligonucleotide analogs with an achiral peptide backbone. Journal of the American Chemical Society, 114, 1895–1897.
Egholm, M., Buchardt, O., Christensen, L., et al. (1993). PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature, 365, 566–568.
Schmidt, J. G., Nielsen, P. E., & Orgel, L. E. (1997). Information transfer from DNA to peptide nucleic acids by template-directed syntheses. Nucleic Acids Research, 25, 4792–4796.
Schmidt, J. G., Nielsen, P. E., & Orgel, L. E. (1997). Information transfer from peptide nucleic acids to RNA by template-directed synthesis. Nucleic Acids Research, 25, 4797–4802.
Koppitz, M., Nielsen, P. E., & Orgel, L. E. (1998). Formation of oligonucleotide-PNA-chimeras by template-directed ligation. Journal of the American Chemical Society, 120, 4563–4569.
Kauffman, S. A. (1986). Autocatalytic sets of proteins. Journal of Theoretical Biology, 119, 1–24.
Wächtershäuser, G. (1988). Before enzymes and templates: Theory of surface metabolism. Microbiological Reviews, 52, 452–484.
Duve, C. (1991). Blueprint for a cell: The nature and origin of life. Burlington, NC: Neil Patterson.