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  • Print publication year: 2020
  • Online publication date: June 2020

Chapter 4 - Premature Ovarian Insufficiency


Although in vitro fertilization (IVF) was developed for the treatment of tubal infertility, [1], it soon became apparent that human IVF had many other applications such as male factor subfertility [2], unexplained subfertility [3] and restoring fertility in women without functioning ovaries using ovum [4] or embryo donation. Although ovum donation was originally used to treat women with Turner’s syndrome [5], it has also been successfully applied to women with other causes of premature ovarian insufficiency (POI) over the last 35 years. The concept of gamete donation is not new, with sperm donation (DI) having been utilized, initially with fresh sperm and subsequently with stored frozen sperm for several decades [6]. In DI the woman’s partner becomes the social father but is not the genetic father, whereas in oocyte donation the woman who has the child is the birth and social mother, but not the genetic mother. Although the child is not directly genetically linked, egg donation allows the patient to carry and deliver her husband’s genetic child.

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