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Chapter 14 - Hormonal Management of Osteoporosis during the Menopause

Published online by Cambridge University Press:  18 June 2020

By
Panagiotis G. Anagnostis  and
John C. Stevenson
Edited by
Nicholas Panay ,
Paula Briggs  and
Gabor T. Kovacs
Nicholas Panay
Affiliation:
Queen Charlotte's & Chelsea Hospital, London
Paula Briggs
Affiliation:
Liverpool Women's NHS Foundation Trust
Gabor T. Kovacs
Affiliation:
Monash University, Victoria
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Summary

Therapies for osteoporosis have been traditionally based on our understanding of bone cell activities. Bone tissue is constantly being removed and replaced (bone turnover) by osteoclasts which resorb bone and osteoblasts which lay down new bone. Bone turnover is essential for the maintenance of a healthy skeleton by removing or repairing the microscopic damage that results from everyday physical activity.

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Chapter
Information
Managing the Menopause , pp. 135 - 143
Publisher: Cambridge University Press
Print publication year: 2020

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References

Eastell, R, Rosen, CJ, Black, DM, Cheung, AM, Murad, MH, Shoback, D. Pharmacological management of osteoporosis in postmenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2019;104:1595–622.Google Scholar
Diez-Perez, A, Adachi, JD, Agnusdei, D, et al., IOF CSA Inadequate Responders Working Group. Treatment failure in osteoporosis. Osteoporos Int 2012;23:2769–74.CrossRefGoogle ScholarPubMed
Anagnostis, P, Paschou, SA, Mintziori, G, et al. Drug holidays from bisphosphonates and denosumab in postmenopausal osteoporosis: EMAS position statement. Maturitas 2017;101:23–30.Google Scholar
Gerval, MO, Stevenson, JC. Treatment of osteoporosis. In: Studd, J, Tan, SL, Chervenak, FA, eds. Current Progress in Obstetrics and Gynaecology. 2014. Tree Life Media pp. 379–93.Google Scholar
Anagnostis, P, Gkekas, NK, Potoupnis, M, Kenanidis, E, Tsiridis, E, Goulis, DG. New therapeutic targets for osteoporosis. Maturitas 2019;120:1–6.Google Scholar

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