In Vitro Methods in Toxicology

doi:10.1017/CBO9780511759956

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In Vitro Methods in Toxicology

In Vitro Methods in Toxicology

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Edited by C. K. Atterwill, C. E. Steele

Publisher:: Cambridge University Press
Online publication date:: August 2010
Print publication year:: 1987
Online ISBN:: 9780511759956
DOI:: https://doi.org/10.1017/CBO9780511759956

Subjects:: Pathology and Laboratory Science, Medicine: General Interest, Medicine

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First published in 1987, this book describes tissue (cell and organ) culture techniques which could be used at a critical predevelopment stage to screen for drug-inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studies. This type of research has important ethical, financial and scientific implications. In particular, less animals and compound are required in in vitro research and more detailed information at the cellular and subcellular levels can be obtained. The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists. It could also form a framework for discussion of potential improvements and modification of toxicity testing.

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In Vitro Methods in Toxicology

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of contributors
pp ix-x

Preface
pp xi-xii

Introduction
pp 1-10

TARGET ORGAN TOXICITY
pp 11-12

In vitro methods in renal toxicology
pp 13-36

Ototoxicity
pp 37-58

Cultured cell models for studying problems in cardiac toxicology
pp 59-108

Use of the isolated rat heart for the detection of cardiotoxic agents
pp 109-132

Brain reaggregate cultures in neurotoxicological investigations
pp 133-164

Application of thryoid cell culture to the study of thyrotoxicity
pp 165-188

In vitro methods to investigate toxic lung disease
pp 189-210

Metabolism and toxicity of drugs in mammalian hepatocyte culture
pp 211-234

In vitro evaluation of haemic systems in toxicology
pp 235-260

GENERAL AND TOPICAL TOXICITY
pp 261-262

The chorioallantoic membrane in irritancy testing
pp 263-278

In vitro dermal irritancy tests
pp 279-298

Genetic toxicology
pp 299-318

In vitro immunotoxicology
pp 319-336

REPRODUCTIVE TOXICITY
pp 337-338

An in vitro test for teratogens using cultures of rat embryo cells
pp 339-364

Postimplantation embryo culture and its application to problems in teratology
pp 365-390

Sub-mammalian and sub-vertebrate models in teratogenicity screening
pp 391-410

The use of in vitro techniques to investigate the action of testicular toxicants
pp 411-424

An in vitro assessment of ovarian function: a potential tool for investigating mechanisms of toxicity in the ovary
pp 425-440

CONCLUSION
pp 441-442

Conclusion
pp 443-446

Index
pp 447-458

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In Vitro Methods in Toxicology

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